Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

DCPFCB 1,2-dichloro-1,2,3,3,4,4- hexafluoro...

Synonyms: CHEMBL446843, AG-K-60526, ACMC-20ap6f, KST-1B3643, AC1Q4KWJ, ...

Kindler, C.H. et al., Taylor, D.M. et al., Perouansky, M. et al., Kendig, J.J. et al., Dutton, R.C. et al., et al.

Taylor, Eger, Bickler, Dutton, Maurer, Sonner, Fanselow, Laster, Eger, Perouansky, Pearce, Kindler, Girard, Gong, Urwyler, Eger, Halsey, Koblin, Laster, Ionescu, Königsberger, Fan, Nguyen, Hudlicky,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BRN 1909267

The differential effect of halothane and 1,2-dichlorohexafluorocyclobutane on in vitro muscle contractures of patients susceptible to malignant hyperthermia [1].

Psychiatry related information on BRN 1909267

BACKGROUND: Although it does not suppress movement in response to noxious stimuli, the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, also known as 2N) does cause amnesia and seizures [2].
IMPLICATIONS: The nonimmobilizer 1,2-dichlorohexafluorocyclobutane has a greater depressant effect on long-term memory than short-term memory, suggesting that it impairs the processes responsible for the retention of memory more than for the formation of memory itself [3].

High impact information on BRN 1909267

Fluorescence polarization studies showed that anesthetics (enflurane and F3), but not nonasthetics (1,2 dichlorohexafluorocyclobutane and 2,3-chlorooctafluorobutane) disordered membrane lipids [4].
In contrast, ketamine (up to 100 microm) and the nonimmobilizer F6 (1,2-dichlorohexafluorocyclobutane, 25 microm) did not significantly affect ppFAK phosphorylation [5].
Effects on synaptic inhibition in the hippocampus do not underlie the amnestic and convulsive properties of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane [2].
In contrast, the nonanesthetic 1,2-dichlorohexafluorocyclobutane did not potentiate TOK1 currents in concentrations up to five times the MAC value predicted by the Meyer-Overton hypothesis based on oil/gas partition coefficients [6].
IMPLICATIONS: Using in vitro contracture tests, we showed that halothane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane differ in their effects on contractures of muscle bundles from individuals susceptible to malignant hyperthermia (MH) as a result of their differing action on MH ryanodine receptors [1].

Biological context of BRN 1909267

Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats [7].
The nonimmobilizer 1,2-dichlorohexafluorocyclobutane does not affect thermoregulation in the rat [8].
IMPLICATIONS: Although the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (2N) suppresses learning, we find that 2N does not depress middle latency auditory-evoked responses [9].
In contrast, at concentrations below (0.4 times) predicted MAC, the nonimmobilizer, 1,2 dichlorohexafluorocyclobutane (2N), slightly (not significantly) increased population spike amplitude, decreased population spike latency 9% +/- 4%, and increased excitatory postsynaptic potentials 22% +/- 16% [7].
The non-anesthetic 1,2-dichlorohexafluorocyclobutane increased monosynaptic reflex, depressed slow ventral root potential approximately 50%, had little effect on muscimol-evoked dorsal root potential, and irreversibly depressed dorsal root-evoked dorsal root potential [10].

Associations of BRN 1909267 with other chemical compounds

IMPLICATIONS: Halothane, but not the nonimmobilizers 1,2-dichlorohexafluorocyclobutane and perfluoropentane, inhibits hippocampal synaptic transmission at Schaffer collateral-CA1 synapses [7].
IMPLICATIONS: Cis-trans isomerism can influence the convulsant properties of the nonimmobilizer 2N (1,2-dichlorohexafluorocyclobutane) and the anesthetic properties of dichloroethylene [11].

Gene context of BRN 1909267

We designed this study to test the hypothesis that the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (2N) compared with halothane has different effects on in vitro muscle contractures of muscle bundles from MH-susceptible (MHS) individuals [1].

References

The differential effect of halothane and 1,2-dichlorohexafluorocyclobutane on in vitro muscle contractures of patients susceptible to malignant hyperthermia. Kindler, C.H., Girard, T., Gong, D., Urwyler, A. Anesth. Analg. (2002) [Pubmed]
Effects on synaptic inhibition in the hippocampus do not underlie the amnestic and convulsive properties of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane. Perouansky, M., Pearce, R.A. Anesthesiology (2004) [Pubmed]
Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory. Dutton, R.C., Maurer, A.J., Sonner, J.M., Fanselow, M.S., Laster, M.J., Eger, E.I. Anesth. Analg. (2002) [Pubmed]
Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Mihic, S.J., McQuilkin, S.J., Eger, E.I., Ionescu, P., Harris, R.A. Mol. Pharmacol. (1994) [Pubmed]
Effects of anesthetic agents on focal adhesion kinase (pp125FAK) tyrosine phosphorylation in rat hippocampal slices. Dahmani, S., Tesnière, A., Rouelle, D., Toutant, M., Desmonts, J.M., Mantz, J. Anesthesiology (2004) [Pubmed]
TOK1 is a volatile anesthetic stimulated K+ channel. Gray, A.T., Winegar, B.D., Leonoudakis, D.J., Forsayeth, J.R., Yost, C.S. Anesthesiology (1998) [Pubmed]
Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats. Taylor, D.M., Eger, E.I., Bickler, P.E. Anesth. Analg. (1999) [Pubmed]
The nonimmobilizer 1,2-dichlorohexafluorocyclobutane does not affect thermoregulation in the rat. Maurer, A.J., Sessler, D.I., Eger, E.I., Sonner, J.M. Anesth. Analg. (2000) [Pubmed]
Inhaled nonimmobilizers do not alter the middle latency auditory-evoked response of rats. Dutton, R.C., Rampil, I.J., Eger, E.I. Anesth. Analg. (2000) [Pubmed]
Correlates of anesthetic properties in isolated spinal cord: cyclobutanes. Kendig, J.J., Kodde, A., Gibbs, L.M., Ionescu, P., Eger, E.I. Eur. J. Pharmacol. (1994) [Pubmed]
The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene. Eger, E.I., Halsey, M.J., Koblin, D.D., Laster, M.J., Ionescu, P., Königsberger, K., Fan, R., Nguyen, B.V., Hudlicky, T. Anesth. Analg. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.