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Gene Review

CD96  -  CD96 molecule

Homo sapiens

Synonyms: Cell surface antigen CD96, T cell-activated increased late expression protein, T-cell surface protein tactile, TACTILE
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Disease relevance of CD96


Psychiatry related information on CD96

  • The neuropsychological tests included: Tactile Naming Test (TNT), Same-Different Recognition Test (SDRT), and Tactile Finger Localization Test (intra- and intermanual tasks, TFLT) [3].
  • CONCLUSION: Tactile receptive communication is possible through the use of a mechanical device used to create tactile illusions [4].
  • A group of children (primarily learning disabled) was divided into analysis (n = 488) and cross-validation (n = 400) samples and the following measures were taken for both the LH and the RH Tactile Perception, Finger Agnosia, Fingertip Number Writing, Tactile Form Recognition, Finger Tapping, Grip Strength, Grooved Pegboard, and Mazes [5].
  • Fifteen school-aged boys with full-mutation FXS were assessed with three occupational performance measures (School Function Assessment, Vineland Adaptive Behavior Scales, play duration) and three sensory processing measures (Sensory Profile, Tactile Defensiveness and Discrimination Test-Revised, Sensory Approach-Avoidance Rating) [6].
  • Adult performance on the Southern California Kinesthesis and Tactile Perception Tests [7].

High impact information on CD96

  • In this study, we show that NK cells recognize PVR through an additional receptor, CD96, or T cell-activated increased late expression (Tactile) [8].
  • We have identified and cloned cDNA for a novel cell-surface protein that we have named Tactile for T cell activation, increased late expression [9].
  • We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance [10].
  • RESULTS: Tactile stimulation of the vulvar epithelium initiates changes suggesting complex integrative mechanisms [11].
  • METHODS: Tactile temporal thresholds were measured in 61 MS patients during two separate test sessions within three weeks [12].

Biological context of CD96

  • Blood pressure X age interactions were seen for Trailmaking-B Test and the Tactile Performance Test-Localization for the primary sample [13].

Anatomical context of CD96

  • BACKGROUND: Tactile temporal thresholds are typically significantly higher (ie, prolonged) in multiple sclerosis (MS) patients when compared to controls and increase significantly during relapses, probably reflecting integrity of conduction across a portion of the corpus callosum [12].
  • RESULTS: Tactile SEFs in primary somatosensory cortex (SI) consisted of two deflections: N24mT and P55mT [14].
  • The study was conducted on 92 root canals selected from teeth advised for extraction to evaluate the efficacy of an electronic device (NEOSONO D-SE), Ingles method and Digital Tactile method for the measurement of working length of tooth [15].
  • Moreover two devices were used to evaluate the threshold: the Optacon Tactile Tester and the "multirod". Based on the characteristics of these devices and the known properties of mechanoreceptors, it is argued that the two devices test different mechanoreceptor systems [16].

Associations of CD96 with chemical compounds

  • In this condition the experimenter pointed out sequentially all the 11 decision points with a verbal description.In the Tactile Map Condition people handled a tactile map along the learning trial [17].

Analytical, diagnostic and therapeutic context of CD96


  1. Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. Gramatzki, M., Ludwig, W.D., Burger, R., Moos, P., Rohwer, P., Grünert, C., Sendler, A., Kalden, J.R., Andreesen, R., Henschke, F., Moldenhauer, G. Exp. Hematol. (1998) [Pubmed]
  2. Tactile temporal thresholds detect relapse-related changes in multiple sclerosis: a preliminary study. Brown, L.N., Metz, L.M. Mult. Scler. (2005) [Pubmed]
  3. Posterior corpus callosum and interhemispheric transfer of somatosensory information: an fMRI and neuropsychological study of a partially callosotomized patient. Fabri, M., Polonara, G., Del Pesce, M., Quattrini, A., Salvolini, U., Manzoni, T. Journal of cognitive neuroscience. (2001) [Pubmed]
  4. Tactile illusion-produced number perception in blind and sighted persons. Gonzales, G.R., Lewis, S.A., Weaver, A.L., Paul, D. Mayo Clin. Proc. (1998) [Pubmed]
  5. Discriminant validity of lateral sensorimotor tests in children. Francis, D.J., Fletcher, J.M., Rourke, B.P. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1988) [Pubmed]
  6. Sensory processing correlates of occupational performance in children with fragile X syndrome: preliminary findings. Baranek, G.T., Chin, Y.H., Hess, L.M., Yankee, J.G., Hatton, D.D., Hooper, S.R. The American journal of occupational therapy. : official publication of the American Occupational Therapy Association. (2002) [Pubmed]
  7. Adult performance on the Southern California Kinesthesis and Tactile Perception Tests. Hsu, Y.T., Nelson, D.L. The American journal of occupational therapy. : official publication of the American Occupational Therapy Association. (1981) [Pubmed]
  8. Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). Fuchs, A., Cella, M., Giurisato, E., Shaw, A.S., Colonna, M. J. Immunol. (2004) [Pubmed]
  9. Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily. Wang, P.L., O'Farrell, S., Clayberger, C., Krensky, A.M. J. Immunol. (1992) [Pubmed]
  10. The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance. Fuchs, A., Colonna, M. Semin. Cancer Biol. (2006) [Pubmed]
  11. Arousing properties of the vulvar epithelium. Martin-Alguacil, N., Schober, J., Kow, L.M., Pfaff, D. J. Urol. (2006) [Pubmed]
  12. Identifying reliable change in tactile temporal thresholds in multiple sclerosis: test-retest reliability. Brown, L.N., Metz, L.M., Eliasziw, M. Mult. Scler. (2006) [Pubmed]
  13. Is blood pressure an important variable in research on aging and neuropsychological test performance? Elias, M.F., Robbins, M.A., Schultz, N.R., Pierce, T.W. Journal of gerontology. (1990) [Pubmed]
  14. Neuromagnetic somatosensory responses to natural moving tactile stimulation. Lin, Y.Y., Kajola, M. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (2003) [Pubmed]
  15. Evaluation of accuracy of an electric device (Neosono D-SE) for the measurement of tooth length. Bal, C.S., Chaudhary, M. Indian journal of dental research : official publication of Indian Society for Dental Research. (1989) [Pubmed]
  16. Vibration sensitivity as a parameter for detecting peripheral neuropathy. I. Results in healthy workers. Muijser, H., Hooisma, J., Hoogendijk, E.M., Twisk, D.A. International archives of occupational and environmental health. (1986) [Pubmed]
  17. Wayfinding tasks in visually impaired people: the role of tactile maps. Caddeo, P., Fornara, F., Nenci, A.M., Piroddi, A. Cognitive processing. (2006) [Pubmed]
  18. Early experience with the American Medical Systems new tactile pump: results of a multicenter study. Delk, J., Knoll, L.D., McMurray, J., Shore, N., Wilson, S. The journal of sexual medicine. (2005) [Pubmed]
  19. Practical evaluation procedure to assess and remediate speech perception skills. Vergara, K.C., Miskiel, L.W., Oller, D.K., Eilers, R.E. Scandinavian audiology. Supplementum. (1997) [Pubmed]
  20. Reliability and validity of the Ohwaki-Kohs Tactile Block Design Test for the Blind. Brand, H.J., Pieterse, M.J., Frost, M. Psychological reports. (1986) [Pubmed]
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