Disease relevance of Cochlear Implants

• Although there is a 17% to 56% incidence of sensorineural hearing loss following head injury, to our knowledge cochlear implants have not been used in treatment of this problem in patients with cognitive deficits and aphasia [1].
• OBJECTIVE: To illustrate that a patient with a cochlear implant may be at increased risk of meningitis secondary to developmental anatomic abnormality associated with the underlying sensorineural hearing loss, as opposed to the implant itself [2].
• METHODS: Direct sequence of GJB2 was conducted over seven cochlear implant users with prelingual hearing impairment and their speech, language and cognitive performance was examined [3].
• Analogous to the cochlear implants for some forms of deafness, these devices could restore useful vision by converting visual information into patterns of electrical stimulation that would excite the remaining spared inner retinal neurons in patients with diseases such as retinitis pigmentosa and age-related macular degeneration [4].
• INTRODUCTION: It is important to differentiate cochlear implant candidates with profound sensorineural hearing loss from those with profound mixed hearing loss [5].

Psychiatry related information on Cochlear Implants

• Speech-perception scores using the TESM strategy were compared to scores using the spectral maxima sound processor (SMSP) strategy in a group of eight adult users of the Nucleus 22 cochlear implant system [6].

High impact information on Cochlear Implants

• Cochlear implants have dramatically changed the treatment and prognosis for patients with profound sensorineural hearing loss [7].
• PURPOSE: To determine the response of cochlear implants ("bionic ears") to therapeutic irradiation [8].
• Performance of cochlear implant recipients with GJB2-related deafness [9].
• However, these experiments have also shown that the optimal addition of noise to cochlear implant signals can enhance the temporal representation of speech cues [R. P. Morse and E. F. Evans, Nature Medicine 2, 928 (1996)] [10].
• We describe the management of a patient with Fechtner's syndrome involving desmopressin, prednisone, and platelets, which produced safe and effective results during cochlear implant surgery [11].

Chemical compound and disease context of Cochlear Implants

• Comparison of speech perception performance between the Nucleus 24 and Nucleus 24 Contour cochlear implant systems [12].

Biological context of Cochlear Implants

• OBJECTIVE: The primary goal of this study was to examine changes that may occur in electrode impedance, electrically evoked compound action potential (EAP) threshold and slope of the EAP growth function, and behavioral measures of threshold T-level) and maximum comfort (C-level) over time in both adult and child cochlear implant users [13].
• OBJECTIVE: The main objective of this study was to assess the correlation of auditory event related potential (ERP) measures with behavioral assessment data to identify if ERPs including mismatch negativity (MMN) can be used to categorize cochlear implant patients into good and poor performers [14].
• OBJECTIVE: The objective of this study was to determine the relationship between electrically evoked whole nerve action potential (EAP) and electrical auditory brain stem response (EABR) thresholds and MAP threshold (T-level) and maximum comfort level (C-level) for subjects who use the Nucleus 24 cochlear implant system [15].
• Neurophysiology of cochlear implant users I: effects of stimulus current level and electrode site on the electrical ABR, MLR, and N1-P2 response [16].
• Measures that can be used to assess auditory development in this population and the application of some of these procedures in the pediatric study of the Clarion cochlear implant (Advanced Bionics Corp., Sylmar, Calif.) are also presented [17].

Anatomical context of Cochlear Implants

• Facial nerve stimulation produced by cochlear implants in patients with cochlear otosclerosis [18].
• Aside from the initial examination of the temporal bones, radiologic control examinations were performed after insertion of titanium, gold, and platinum middle-ear implants and a cochlear implant [19].
• CONCLUSIONS: Damage to the carotid canal and the carotid artery is a potential risk of cochlear implant surgery [20].
• Perilymph and serum samples from 7 patients with otosclerosis and 2 recipients of cochlear implants were used as controls [21].
• Preservation of neurons in the spiral ganglion suggests that long-term successful habilitation with cochlear implants may be possible in persons with severe-to-profound or profound Cx26-related deafness [22].

Associations of Cochlear Implants with chemical compounds

• Ten months after starting cyclosporine treatment her course was stable and cochlear implant surgery was successfully performed [23].
• Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants [24].
• DESIGN: Phase 1 involved an examination of the clinical MAPs for the first 103 recipients implanted with the Contour electrode array in the Melbourne Cochlear Implant Clinic, to examine the ability to predict the entire MAP based on a smaller number of clinically determined T- and/or C-levels [25].
• Cochlear implant fixation using titanium screws [26].
• This paper deals with the Nucleus C124R (CS) (Contour) cochlear Implant: its characteristics, differences compared with the previous generation of devices, the perimodiolar electrode, and the surgical technique used for safe insertion [27].

Gene context of Cochlear Implants

• OBJECTIVE: To determine the relationship between ethnicity and mutations in the GJB2 and GJB6 genes in multi-cultural patients enrolled in a Canadian paediatric Cochlear Implant Program. METHODS: Blood was analyzed from 65 paediatric cochlear implant users by direct sequencing of the coding region and intron/exon boundaries of the GBJ2 gene [28].
• I give some qualified support to the first and second claim, but find that the principal weight of the argument must be borne by the third argument: that use of the cochlear implants is impermissible because Deaf culture is intrinsically valuable [29].
• Speech-evoked cognitive P300 potentials in cochlear implant recipients [30].
• CONCLUSIONS: The close approximation of the measured data to the model data indicates the feasibility of the clinical use of an EAP-based cochlear implant fitting protocol [31].
• A method for recording the electrically evoked whole-nerve action potential (EAP) at the time of cochlear implant surgery is described [32].

Analytical, diagnostic and therapeutic context of Cochlear Implants

• Management of the child with sensorineural hearing loss. Medical, surgical, hearing aids, cochlear implants [33].
• DESIGN: Eight adult cochlear implant participants participated in a randomized, double-blind study and received either 10 mg d-amphetamine (Treatment group, N = 4) or a placebo (Placebo group, N = 4) 60 minutes prior to a 1.5 hour intensive aural rehabilitation session occurring twice a week for two months [34].
• The purpose of the experiment was to determine if the most-confortable-listening (MCL) levels and loudness-discomfort levels (LDLs) can be predicted from threshold measurements obtained from patients with cochlear implants using direct electrical stimulation [35].
• The results suggest that the P300 may serve as a useful tool for evaluating the cognitive aspects of auditory processing in cochlear implant recipients, and that it may aid in assessing the success of cochlear implantation [30].
• Those suffering from a severe to profound sensorineural hearing loss can obtain substantial benefit from a cochlear implant prosthesis [36].

References