High impact information on Do

• As in embryologically initiated hair germs, transgenic follicles induce Lef-1, but follicles are disoriented and defective in sonic hedgehog polarization [1].
• In support of these observations, mouse embryonic fibroblasts derived from Fes-deficient mice displayed an aberrant structure of nucleation and centrosome with unbundling and disoriented filaments of microtubules [2].
• Transgenic guard hairs are significantly elongated and a small fraction of hair follicles is severely disoriented [3].
• In the adult mea/mea, the dendrites of these ectopic cells are atrophic and disoriented [4].
• Electron microscopy revealed that microtubules and neurofilaments are disorganized and disoriented by capsaicin [5].

Biological context of Do

• Whiskers amiss (wam) is a new spontaneous recessive mutation in the SELH/Bc strain of mice that causes a phenotype of askew, sometimes kinked or curled, breakable whiskers and disheveled-appearing body hair, apparently owing to disoriented guard hairs [6].
• Collagen gel overlay induces apoptosis of polarized cells in cultures: disoriented cell death [7].

Anatomical context of Do

• The Purkinje cells developed misshapen, progressively disoriented dendritic stems lacking tertiary dendrites and studded with numerous spines, devoid of afferent synaptic contacts (naked spines) and encased by glial processes [8].
• Radially ascending Bergmann fibers, as well as disoriented ones, arose from the soma of these varieties of Golgi epithelial cells [9].
• Despite the normal presence of Bdnf transcript, afferent fibers are disoriented near the organ of Corti [10].
• As a result of Z line loss, sarcomeres were disoriented [11].
• Arrangements of neuroepithelial cells were disturbed and processes of radial glia were disoriented in the fused lesions [12].

Associations of Do with chemical compounds

• Hepatic parenchymal cells of mice fed with a 0.5% cuprizone-diet for 7-8 days were characterized by megamitochondria with numerous cristae including disoriented, shorter ones than those of the control and those in vesicular configuration [13].

Other interactions of Do

• In MAM0 animals, the Purkinje cells appeared malpositioned and disoriented, the pinceau around the Purkinje cell hillock was absent, but basket cell axons were present [14].

References