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Chemical Compound Review

Cuprizone     N,N'- bis(cyclohexylideneamino) ethanediamide

Synonyms: Cuprizon, Cuprizane, Cupferazone, Cuprizon 1, EthAI-EO(1/4)A, ...
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Disease relevance of Cuprizone


Psychiatry related information on Cuprizone


High impact information on Cuprizone


Chemical compound and disease context of Cuprizone

  • Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain [11].
  • On the basis of these results the inhibition of adenylate cyclase produced by TET in brain homogenates in vitro would not appear to be involved in the development of nervous changes associated with acute TET toxicity, or in the production of progressive brain oedema caused by TET, HCP and cuprizone [12].

Biological context of Cuprizone

  • When 8 week old C57BL/6 mice are fed 0.2% cuprizone in the diet, mature olidgodendroglia are specifically insulted (cannot fulfill the metabolic demand of support of vast amounts of myelin) and go through apoptosis [13].
  • We therefore investigated histology and ultrastructure during the early oligodendrocyte differentiation phase of remyelination in mice given cuprizone and allowed to recover for 2 weeks [2].
  • In addition, cuprizone treatment severely altered copper and zinc homeostasis in the central nervous system (CNS) as well as in all other tissues examined, with increasing metal ion concentrations particularly in the CNS [4].
  • This upregulation is brain-specific, as p8 is not elevated in the liver, lung, kidney, spleen, and heart of cuprizone-treated mice [5].
  • We also localized the cellular source of p8 during cuprizone treatment, and further found elevated expression during embryogenesis but not in normal adult brain [5].

Anatomical context of Cuprizone


Associations of Cuprizone with other chemical compounds


Gene context of Cuprizone


Analytical, diagnostic and therapeutic context of Cuprizone


  1. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Arnett, H.A., Mason, J., Marino, M., Suzuki, K., Matsushima, G.K., Ting, J.P. Nat. Neurosci. (2001) [Pubmed]
  2. Quantifying the early stages of remyelination following cuprizone-induced demyelination. Stidworthy, M.F., Genoud, S., Suter, U., Mantei, N., Franklin, R.J. Brain Pathol. (2003) [Pubmed]
  3. Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Chen, M.K., Baidoo, K., Verina, T., Guilarte, T.R. Brain (2004) [Pubmed]
  4. Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment. Zatta, P., Raso, M., Zambenedetti, P., Wittkowski, W., Messori, L., Piccioli, F., Mauri, P.L., Beltramini, M. Cell. Mol. Life Sci. (2005) [Pubmed]
  5. Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues. Plant, S.R., Wang, Y., Vasseur, S., Thrash, J.C., McMahon, E.J., Bergstralh, D.T., Arnett, H.A., Miller, S.D., Carson, M.J., Iovanna, J.L., Ting, J.P. Glia (2006) [Pubmed]
  6. Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis. Liebetanz, D., Merkler, D. Exp. Neurol. (2006) [Pubmed]
  7. Membrane potential of mitochondrial measured with microelectrodes. Maloff, B.L., Scordilis, S.P., Tedeschi, H. Science (1977) [Pubmed]
  8. Membrane potentials and resistances of giant mitochondria. Metabolic dependence and the effects of valinomycin. Maloff, B.L., Scordilis, S.P., Reynolds, C., Tedeschi, H. J. Cell Biol. (1978) [Pubmed]
  9. Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Emery, B., Cate, H.S., Marriott, M., Merson, T., Binder, M.D., Snell, C., Soo, P.Y., Murray, S., Croker, B., Zhang, J.G., Alexander, W.S., Cooper, H., Butzkueven, H., Kilpatrick, T.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Komoly, S., Hudson, L.D., Webster, H.D., Bondy, C.A. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain. Jurevics, H., Hostettler, J., Muse, E.D., Sammond, D.W., Matsushima, G.K., Toews, A.D., Morell, P. J. Neurochem. (2001) [Pubmed]
  12. Effect of organotin compounds and hexachlorophene on brain adenosine cyclic 3',5'-monophosphate metabolism. Leow, A.C., Towns, K.M., Leaver, D.D. Chem. Biol. Interact. (1979) [Pubmed]
  13. The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Matsushima, G.K., Morell, P. Brain Pathol. (2001) [Pubmed]
  14. Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. Mason, J.L., Ye, P., Suzuki, K., D'Ercole, A.J., Matsushima, G.K. J. Neurosci. (2000) [Pubmed]
  15. Absence of macrophage-inflammatory protein-1alpha delays central nervous system demyelination in the presence of an intact blood-brain barrier. McMahon, E.J., Cook, D.N., Suzuki, K., Matsushima, G.K. J. Immunol. (2001) [Pubmed]
  16. Mobility in the mitochondrial electron transport chain. Hochman, J., Ferguson-Miller, S., Schindler, M. Biochemistry (1985) [Pubmed]
  17. A CIITA-independent pathway that promotes expression of endogenous rather than exogenous peptides in immune-privileged sites. Arancibia-Cárcamo, C.V., Osawa, H., Arnett, H.A., Háskova, Z., George, A.J., Ono, S.J., Ting, J.P., Streilein, J.W. Eur. J. Immunol. (2004) [Pubmed]
  18. Biochemical changes in Cuprizone-induced spongiform encephalopathy. I. Changes in the activities of 2',3'-cyclic nucleotide 3'-phosphohydrolase, oligodendroglial ceramide galactosyl transferase, and the hydrolysis of the alkenyl group of alkenyl, acyl-glycerophospholipids by plasmalogenase in different regions of the brain. Carey, E.M., Freeman, N.M. Neurochem. Res. (1983) [Pubmed]
  19. Purification of benzylamine oxidase from cultured porcine aortic smooth muscle cells. Hysmith, R.M., Boor, P.J. Biochem. Cell Biol. (1988) [Pubmed]
  20. The failure of supplemental dietary copper to prevent cuprizone-induced alterations in mouse hepatocytes. Tandler, B., Hoppel, C.L. Beiträge zur Pathologie. (1975) [Pubmed]
  21. Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination. Stidworthy, M.F., Genoud, S., Li, W.W., Leone, D.P., Mantei, N., Suter, U., Franklin, R.J. Brain (2004) [Pubmed]
  22. Interferon-gamma protects against cuprizone-induced demyelination. Gao, X., Gillig, T.A., Ye, P., D'Ercole, A.J., Matsushima, G.K., Popko, B. Mol. Cell. Neurosci. (2000) [Pubmed]
  23. Endogenous cell repair of chronic demyelination. Armstrong, R.C., Le, T.Q., Flint, N.C., Vana, A.C., Zhou, Y.X. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  24. Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination. Seiwa, C., Yamamoto, M., Tanaka, K., Fukutake, M., Ueki, T., Takeda, S., Sakai, R., Ishige, A., Watanabe, K., Akita, M., Yagi, T., Tanaka, K., Asou, H. J. Neurosci. Res. (2007) [Pubmed]
  25. An autoradiographic study of cellular proliferation in remyelination of the central nervous system. Ludwin, S.K. Am. J. Pathol. (1979) [Pubmed]
  26. Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination. Woodruff, R.H., Fruttiger, M., Richardson, W.D., Franklin, R.J. Mol. Cell. Neurosci. (2004) [Pubmed]
  27. Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood-brain barrier. McMahon, E.J., Suzuki, K., Matsushima, G.K. J. Neuroimmunol. (2002) [Pubmed]
  28. Channels in the mitochondrial outer membrane: evidence from patch clamp studies. Tedeschi, H., Kinnally, K.W. J. Bioenerg. Biomembr. (1987) [Pubmed]
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