Gene Review:
Lef1 - lymphoid enhancer binding factor 1
Mus musculus
Synonyms:
3000002B05, AI451430, LEF-1, Lef-1, Lymphoid enhancer-binding factor 1, ...
- Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor beta-induced repression of c-myc. Sasaki, T., Suzuki, H., Yagi, K., Furuhashi, M., Yao, R., Susa, S., Noda, T., Arai, Y., Miyazono, K., Kato, M. Cancer Res. (2003)
- Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy. Armstrong, D.D., Esser, K.A. Am. J. Physiol., Cell Physiol. (2005)
- Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1). Duan, D., Yue, Y., Zhou, W., Labed, B., Ritchie, T.C., Grosschedl, R., Engelhardt, J.F. Development (1999)
- Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Kim, K., Pang, K.M., Evans, M., Hay, E.D. Mol. Biol. Cell (2000)
- Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression. Nguyen, A., Rosner, A., Milovanovic, T., Hope, C., Planutis, K., Saha, B., Chaiwun, B., Lin, F., Imam, S.A., Marsh, J.L., Holcombe, R.F. Int. J. Oncol. (2005)
- De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Gat, U., DasGupta, R., Degenstein, L., Fuchs, E. Cell (1998)
- Structural basis for DNA bending by the architectural transcription factor LEF-1. Love, J.J., Li, X., Case, D.A., Giese, K., Grosschedl, R., Wright, P.E. Nature (1995)
- Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Eastman, Q., Grosschedl, R. Curr. Opin. Cell Biol. (1999)
- Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Kratochwil, K., Dull, M., Farinas, I., Galceran, J., Grosschedl, R. Genes Dev. (1996)
- Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Galceran, J., Fariñas, I., Depew, M.J., Clevers, H., Grosschedl, R. Genes Dev. (1999)
- Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Reya, T., O'Riordan, M., Okamura, R., Devaney, E., Willert, K., Nusse, R., Grosschedl, R. Immunity (2000)
- Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Boras-Granic, K., Chang, H., Grosschedl, R., Hamel, P.A. Dev. Biol. (2006)
- FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Kratochwil, K., Galceran, J., Tontsch, S., Roth, W., Grosschedl, R. Genes Dev. (2002)
- Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Merrill, B.J., Gat, U., DasGupta, R., Fuchs, E. Genes Dev. (2001)
- Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Okamura, R.M., Sigvardsson, M., Galceran, J., Verbeek, S., Clevers, H., Grosschedl, R. Immunity (1998)
- Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Niemann, C., Unden, A.B., Lyle, S., Zouboulis, C.h.C., Toftgård, R., Watt, F.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Mailleux, A.A., Spencer-Dene, B., Dillon, C., Ndiaye, D., Savona-Baron, C., Itoh, N., Kato, S., Dickson, C., Thiery, J.P., Bellusci, S. Development (2002)
- HIC-5 is a novel repressor of lymphoid enhancer factor/T-cell factor-driven transcription. Ghogomu, S.M., van Venrooy, S., Ritthaler, M., Wedlich, D., Gradl, D. J. Biol. Chem. (2006)
- Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2. Li, F.Q., Person, R.E., Takemaru, K., Williams, K., Meade-White, K., Ozsahin, A.H., Güngör, T., Moon, R.T., Horwitz, M. J. Biol. Chem. (2004)
- Alx4 binding to LEF-1 regulates N-CAM promoter activity. Boras, K., Hamel, P.A. J. Biol. Chem. (2002)
- Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. Kim, K., Lee, K.Y. Cell Biol. Int. (2001)
- TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. Nawshad, A., Hay, E.D. J. Cell Biol. (2003)
- Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Yamada, T., Mori, Y., Hayashi, R., Takada, M., Ino, Y., Naishiro, Y., Kondo, T., Hirohashi, S. Cancer Res. (2003)
- Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc. Mei, J.M., Hord, N.G., Winterstein, D.F., Donald, S.P., Phang, J.M. Carcinogenesis (1999)
- Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. Prieve, M.G., Guttridge, K.L., Munguia, J., Waterman, M.L. Mol. Cell. Biol. (1998)
- PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Amen, M., Liu, X., Vadlamudi, U., Elizondo, G., Diamond, E., Engelhardt, J.F., Amendt, B.A. Mol. Cell. Biol. (2007)
- Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. Eger, A., Stockinger, A., Schaffhauser, B., Beug, H., Foisner, R. J. Cell Biol. (2000)
- Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. Soriano, S., Kang, D.E., Fu, M., Pestell, R., Chevallier, N., Zheng, H., Koo, E.H. J. Cell Biol. (2001)
- Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos. Eblaghie, M.C., Song, S.J., Kim, J.Y., Akita, K., Tickle, C., Jung, H.S. J. Anat. (2004)
- The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Li, B., Mackay, D.R., Dai, Q., Li, T.W., Nair, M., Fallahi, M., Schonbaum, C.P., Fantes, J., Mahowald, A.P., Waterman, M.L., Fuchs, E., Dai, X. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dassule, H.R., McMahon, A.P. Dev. Biol. (1998)
- Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling. Sakai, D., Tanaka, Y., Endo, Y., Osumi, N., Okamoto, H., Wakamatsu, Y. Dev. Growth Differ. (2005)
- PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter. Vadlamudi, U., Espinoza, H.M., Ganga, M., Martin, D.M., Liu, X., Engelhardt, J.F., Amendt, B.A. J. Cell. Sci. (2005)
- Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf. Milatovich, A., Travis, A., Grosschedl, R., Francke, U. Genomics (1991)
- Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype. Mei, J.M., Hord, N.G., Winterstein, D.F., Donald, S.P., Phang, J.M. Cancer Res. (2000)