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Gene Review

PPIH  -  peptidylprolyl isomerase H (cyclophilin H)

Homo sapiens

Synonyms: CYP-20, CYP20, CYPH, CypH, MGC5016, ...
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Disease relevance of PPIH

  • In the remaining 626 women, 44 (7.0%) pregnancies ended in a premature delivery, 30 (4.7%) women developed PPIH, 60 (9.6%) infants were SGA (< 10th centile), of which 19 were < 5th centile and five were < 3rd centile, and 23 (3.7%) women suffered an antepartum hemorrhage [1].
  • Using native gel electrophoresis and ACE mobility-shift assays, it was demonstrated that the known moderate affinity of Cyp20 to the capsid protein p24 of HIV-1 was detectable in the case of rDmCyp20 fused to the fluorescent tag [2].

High impact information on PPIH


Biological context of PPIH

  • Here, we demonstrate that recombinant hCypH exhibits peptidyl-prolyl isomerase (PPIase) activity, and describe mutagenesis studies demonstrating that it shares the catalytic pocket with other members of the cyclophilin family [5].
  • Since the catalytic pocket and the second binding site are located on opposite sides of the cyclophilin structure, this opens up the interesting possibility that hCypH may serve as a bridge mediating interactions between protein 60K of the U4/U6 snRNP and other as yet unknown factors [5].


  1. Transvaginal uterine and umbilical artery Doppler examination of 12-16 weeks and the subsequent development of pre-eclampsia and intrauterine growth retardation. Harrington, K., Goldfrad, C., Carpenter, R.G., Campbell, S. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. (1997) [Pubmed]
  2. Application of a green fluorescent fusion protein to study protein-protein interactions by electrophoretic methods. Kiessig, S., Reissmann, J., Rascher, C., Küllertz, G., Fischer, A., Thunecke, F. Electrophoresis (2001) [Pubmed]
  3. The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. Teigelkamp, S., Achsel, T., Mundt, C., Göthel, S.F., Cronshagen, U., Lane, W.S., Marahiel, M., Lührmann, R. RNA (1998) [Pubmed]
  4. (+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes. Nunoya, K., Yokoi, Y., Kimura, K., Kodama, T., Funayama, M., Inoue, K., Nagashima, K., Funae, Y., Shimada, N., Green, C., Kamataki, T. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  5. Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. Ingelfinger, D., Göthel, S.F., Marahiel, M.A., Reidt, U., Ficner, R., Lührmann, R., Achsel, T. Nucleic Acids Res. (2003) [Pubmed]
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