Chemical Compound Review:
SM-10661 (2R,5S)-3,5-dimethyl-2- pyridin-3-yl-1,3...
Synonyms:
SM-12502, AC1L433Y, SM 10661, 130841-70-2, 158511-47-8, ...
This record was replaced with 178015.
- Biological effect of orally active platelet-activating factor receptor antagonist SM-10661. Komuro, Y., Imanishi, N., Uchida, M., Morooka, S. Mol. Pharmacol. (1990)
- A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. Murakami, K., Okajima, K., Uchiba, M., Johno, M., Okabe, H., Takatsuki, K. Thromb. Haemost. (1996)
- Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. Hayashi, J., Hiromura, K., Koizumi, R., Shimizu, Y., Maezawa, A., Nojima, Y., Naruse, T. Nephron (2001)
- A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502). Nunoya, K., Yokoi, T., Kimura, K., Inoue, K., Kodama, T., Funayama, M., Nagashima, K., Funae, Y., Green, C., Kinoshita, M., Kamataki, T. Pharmacogenetics (1998)
- A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans. Nunoya, K.I., Yokoi, T., Kimura, K., Kainuma, T., Satoh, K., Kinoshita, M., Kamataki, T. J. Pharmacol. Exp. Ther. (1999)
- (+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes. Nunoya, K., Yokoi, Y., Kimura, K., Kodama, T., Funayama, M., Inoue, K., Nagashima, K., Funae, Y., Shimada, N., Green, C., Kamataki, T. J. Pharmacol. Exp. Ther. (1996)
- Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs. Uchida, M., Imanishi, N., Sugasawa, T., Morooka, S. Lipids (1991)
- Enticed into molecular toxicology. Kamataki, T. Yakugaku Zasshi (2006)
- Platelet-activating factor and the vascular effects of zymosan in rats. Damas, J., Remacle-Volon, G., Bourdon, V. Eur. J. Pharmacol. (1993)
- Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs. Sugasawa, T., Imanishi, N., Morooka, S. Lipids (1991)
- Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils. Todoroki, H., Higure, A., Okamoto, K., Okazaki, K., Nagafuchi, Y., Takeda, S., Katoh, H., Itoh, H., Ohsato, K., Nakamura, S. J. Surg. Res. (1998)
- Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils. Koike, H., Imanishi, N., Natsume, Y., Morooka, S. Eur. J. Pharmacol. (1994)
- Direct enantiomeric separation of platelet-activating factor receptor antagonist SM-10661 by ligand-exchange high-performance liquid chromatography with a copper (II) N,S-dioctyl-D-penicillamine complex. Okamoto, M., Ueda, Y., Takahashi, K., Nakazawa, H., Doi, T. Biosci. Biotechnol. Biochem. (1995)
- Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk. Kamataki, T., Fujieda, M., Kiyotani, K., Iwano, S., Kunitoh, H. Biochem. Biophys. Res. Commun. (2005)
- Inhibition of leukotriene formation and IL-8 release by the paf-receptor antagonist SM-12502. Hilger, R.A., Köller, M., König, W. Inflammation (1996)
- Effect of a selective PAF antagonist SM-10661 ((+/-)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one HCl) on experimental disseminated intravascular coagulation (DIC). Imanishi, N., Komuro, Y., Morooka, S. Lipids (1991)
- S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. Nunoya, K., Yokoi, T., Itoh, K., Itoh, S., Kimura, K., Kamataki, T. Xenobiotica (1995)