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Gene Review

YKT6  -  YKT6 v-SNARE homolog (S. cerevisiae)

Homo sapiens

Synonyms: Synaptobrevin homolog YKT6
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High impact information on YKT6

  • Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140) [1].
  • Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps [1].
  • The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes [1].
  • In mammals, TI-VAMP and Ykt6 are crucial for neuronal function, and defects in longin structure or function might underlie some human neurological pathologies [2].
  • The functions and cellular localization of longins are regulated at several levels and the longin prototypes TI-VAMP, Sec22 and Ykt6 show different distributions among eukaryotes, reflecting their modular and functional diversity [2].

Biological context of YKT6

  • The N-terminal domain of human Ykt6 contains a Pal-CoA binding site and is required for the reaction [3].
  • Treatment of MCF-7 cells with siRNA specific for CCT5, RGS3, or YKT6 resulted in a significant enhancement of docetaxel-induced apoptosis [4].
  • Farnesylation is the prerequisite for subsequent palmitoylation of the upstream cysteine, which permits stable membrane association of Ykt6 [5].
  • YKT6 is an essential gene that codes for a novel vesicle-associated SNARE functioning at the endoplasmic reticulum-Golgi transport step in the yeast secretory pathway [6].
  • Herein, we report the 2.4 A resolution structure of SEDL, which reveals an unexpected similarity to the structures of the N-terminal regulatory domain of two SNAREs, Ykt6p and Sec22b, despite no sequence homology to these proteins [7].

Anatomical context of YKT6

  • Ykt6 is highly enriched in the cerebral cortex and hippocampus and is targeted to a novel compartment in neurons [8].
  • Depletion of Ykt6p results in the accumulation of the p1 precursor (endoplasmic reticulum form) of the vacuolar enzyme carboxypeptidase Y and morphological abnormalities consistent with a defect in secretion [6].
  • The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion [9].
  • The conservation of Ykt6 and its localization to several organelles suggest that its acyltransferase activity may also be required in other intracellular fusion events [9].

Associations of YKT6 with chemical compounds

  • The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues [3].


  1. An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p. Tochio, H., Tsui, M.M., Banfield, D.K., Zhang, M. Science (2001) [Pubmed]
  2. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Rossi, V., Banfield, D.K., Vacca, M., Dietrich, L.E., Ungermann, C., D'Esposito, M., Galli, T., Filippini, F. Trends Biochem. Sci. (2004) [Pubmed]
  3. The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues. Veit, M. Biochem. J. (2004) [Pubmed]
  4. Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers. Ooe, A., Kato, K., Noguchi, S. Breast Cancer Res. Treat. (2007) [Pubmed]
  5. Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Fukasawa, M., Varlamov, O., Eng, W.S., Söllner, T.H., Rothman, J.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. McNew, J.A., Sogaard, M., Lampen, N.M., Machida, S., Ye, R.R., Lacomis, L., Tempst, P., Rothman, J.E., Söllner, T.H. J. Biol. Chem. (1997) [Pubmed]
  7. Crystal structure of SEDL and its implications for a genetic disease spondyloepiphyseal dysplasia tarda. Jang, S.B., Kim, Y.G., Cho, Y.S., Suh, P.G., Kim, K.H., Oh, B.H. J. Biol. Chem. (2002) [Pubmed]
  8. SNAREs in neurons - beyond synaptic vesicle exocytosis (Review). Wang, Y., Tang, B.L. Mol. Membr. Biol. (2006) [Pubmed]
  9. The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. Dietrich, L.E., Gurezka, R., Veit, M., Ungermann, C. EMBO J. (2004) [Pubmed]
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