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Chemical Compound Review

Sulfapyridazine     4-amino-N-(6- methoxypyridazin-3...

Synonyms: Lederkyn, Lisulfen, Petrisul, Piridolo, Sulfalex, ...
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Disease relevance of Sulfapyridazine


High impact information on Sulfapyridazine

  • The functions and cellular localization of longins are regulated at several levels and the longin prototypes TI-VAMP, Sec22 and Ykt6 show different distributions among eukaryotes, reflecting their modular and functional diversity [6].
  • First, it negatively regulates the ability of TI-VAMP and of a Longin/Synaptobrevin chimera to participate in SNARE complexes [1].
  • Using nuclear magnetic resonance spectroscopy, we establish that the N-terminal domain of the yeast vacuolar R-SNARE Nyv1p adopts a longin-like fold similar to those of Sec22b and Ykt6p [7].
  • A YXXPhi-like adaptin-dependent sorting signal (Y(31)GTI(34)) unique to the longin domain of Nyv1p mediates interactions with the AP3 complex in vivo and in vitro [7].
  • SRbeta is a member of the Ras-GTPase superfamily closely related to Arf and Sar1, while SRX belongs to the SNARE-like superfamily with a fold also known as longin domain [8].

Chemical compound and disease context of Sulfapyridazine


Biological context of Sulfapyridazine


Anatomical context of Sulfapyridazine

  • Nyv1p is sorted to the limiting membrane of the vacuole via the adaptor protein (AP)3 adaptin pathway, and we show that its longin domain is sufficient to direct transport to this location [7].
  • Furthermore, the newly identified DUF254 domain is a distant homolog of the mu-adaptin longin domain found in clathrin adapter protein (AP) complexes of known structure that function to localize cargo protein to specific organelles [13].

Associations of Sulfapyridazine with other chemical compounds


Gene context of Sulfapyridazine

  • However, several sequence-specific surface features of the longin domain indirectly regulate Ykt6 localization through intramolecular interactions that mask otherwise-dominant targeting signals on the SNARE motif and lipid groups [19].
  • This review will highlight recent findings on NTDs of syntaxins, the longin domain of VAMP proteins and SNAP-23/25 homologues in yeast [20].
  • Comparison with the homologous yeast structure and other longin domains reveals a conserved adjustable hydrophobic surface within SRX which is of central importance for the SRbeta-GTP:SRX interface [8].
  • Targeting of Ykt6 to its unique subcellular location was directed by its profilin-like longin domain [19].
  • Both products possess corresponding sequences for longin domain at N-terminus, a soluble N-ethylmaleimide-sensitive factor [NSF] attachment protein receptor (SNARE) coiled-coil region, a transmembrane domain (TM), and an intravesicular tail C-terminal, characteristics of all long VAMPs or longins [21].

Analytical, diagnostic and therapeutic context of Sulfapyridazine


  1. A dual mechanism controlling the localization and function of exocytic v-SNAREs. Martinez-Arca, S., Rudge, R., Vacca, M., Raposo, G., Camonis, J., Proux-Gillardeaux, V., Daviet, L., Formstecher, E., Hamburger, A., Filippini, F., D'Esposito, M., Galli, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. An open clinical trial of sulphamethoxypyridazine in the treatment of mucous membrane pemphigoid. Thornhill, M., Pemberton, M., Buchanan, J., Theaker, E. Br. J. Dermatol. (2000) [Pubmed]
  3. Identification of hitherto unrecognized arboviruses from Ecuador: members of serogroups B, C, Bunyamwera, Patois, and Minatitlan. Calisher, C.H., Gutierrez, E., Francy, D.B., Alava, A., Muth, D.J., Lazuick, J.S. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  4. Obliterative bronchiolitis and alveolitis associated with sulphamethoxypyridazine (Lederkyn) therapy for linear IgA disease of adults. Godfrey, K.M., Wojnarowska, F., Friedland, J.S. Br. J. Dermatol. (1990) [Pubmed]
  5. Sulphamethoxypyridazine for dermatitis herpetiformis, linear IgA disease and cicatricial pemphigoid. McFadden, J.P., Leonard, J.N., Powles, A.V., Rutman, A.J., Fry, L. Br. J. Dermatol. (1989) [Pubmed]
  6. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Rossi, V., Banfield, D.K., Vacca, M., Dietrich, L.E., Ungermann, C., D'Esposito, M., Galli, T., Filippini, F. Trends Biochem. Sci. (2004) [Pubmed]
  7. Identification of the Yeast R-SNARE Nyv1p as a Novel Longin Domain-containing Protein. Wen, W., Chen, L., Wu, H., Sun, X., Zhang, M., Banfield, D.K. Mol. Biol. Cell (2006) [Pubmed]
  8. The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains. Schlenker, O., Hendricks, A., Sinning, I., Wild, K. J. Biol. Chem. (2006) [Pubmed]
  9. A comparative study of some combined treatment regimens in acute toxoplasmosis in mice. Thiermann, E., Apt, W., Atias, A., Lorca, M., Olguín, J. Am. J. Trop. Med. Hyg. (1978) [Pubmed]
  10. Bioavailability of sulfamethoxypyridazine following intramuscular or subcutaneous administration in goats. Garg, S.K., Uppal, R.P. Vet. Res. (1997) [Pubmed]
  11. Serum disappearance and urinary excretion of sulfamethoxypyridazine in goats. Garg, S.K., Uppal, R.P., Rivière, J.E. Revue d'élevage et de médecine vétérinaire des pays tropicaux. (1994) [Pubmed]
  12. Preparation of bone samples in the Gliwice Radiocarbon Laboratory for AMS radiocarbon dating. Piotrowska, N., Goslar, T. Isotopes in environmental and health studies. (2002) [Pubmed]
  13. Longin-like folds identified in CHiPS and DUF254 proteins: Vesicle trafficking complexes conserved in eukaryotic evolution. Kinch, L.N., Grishin, N.V. Protein Sci. (2006) [Pubmed]
  14. Structure and solid-state chemistry of anhydrous and hydrated crystal forms of the trimethoprim-sulfamethoxypyridazine 1:1 molecular complex. Bettinetti, G., Caira, M.R., Callegari, A., Merli, M., Sorrenti, M., Tadini, C. Journal of pharmaceutical sciences. (2000) [Pubmed]
  15. Photocoagulation of active toxoplasmic retinochoroiditis. Ghartey, K.N., Brockhurst, R.J. Am. J. Ophthalmol. (1980) [Pubmed]
  16. Hapten synthesis and development of polyclonal antibody-based multi-sulfonamide immunoassays. Zhang, H., Duan, Z., Wang, L., Zhang, Y., Wang, S. J. Agric. Food Chem. (2006) [Pubmed]
  17. The effect of different sulfonamides on phenytoin metabolism in man. Hansen, J.M., Kampmann, J.P., Siersbaek-Nielsen, K., Lumholtz, I.B., Arrøe, M., Abildgaard, U., Skovsted, L. Acta Med. Scand. Suppl. (1979) [Pubmed]
  18. Validation of an analytical method to determine sulfamides in kidney by HPLC-DAD and PARAFAC2 with first-order derivative chromatograms. García, I., Ortiz, M.C., Sarabia, L., Aldama, J.M. Anal. Chim. Acta (2007) [Pubmed]
  19. Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6. Hasegawa, H., Yang, Z., Oltedal, L., Davanger, S., Hay, J.C. J. Cell. Sci. (2004) [Pubmed]
  20. Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins. Dietrich, L.E., Boeddinghaus, C., LaGrassa, T.J., Ungermann, C. Biochim. Biophys. Acta (2003) [Pubmed]
  21. Characterization of two long vesicle-associated membrane proteins or longins genes from Entamoeba histolytica. Tamayo, E.M., Ondarza, R.N. Arch. Med. Res. (2004) [Pubmed]
  22. The effect of sulphamethoxypyridazine on liver and plasma levels of vitamin A in rats. Bravo, M.E., Monckeberg, F., Urbina, J. Br. J. Pharmacol. (1977) [Pubmed]
  23. Preformulation studies on suppositories by thermal methods. Giordano, F., La Manna, A., Bettinetti, G.P., Zamparutti, M. Bollettino chimico farmaceutico. (1990) [Pubmed]
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