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Gene Review

pol  - 

Rous sarcoma virus

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Disease relevance of pol


High impact information on pol


Chemical compound and disease context of pol

  • The HTLV-1 RT seems to be unique since its NH2 terminus is probably encoded by the pro open reading frame (ORF) fused downstream, via a transframe peptide, to the polypeptide encoded by the pol ORF [8].

Biological context of pol

  • Furthermore, it was shown that the N-terminal ends of the M-MuLV pol product and the CaMV and 17.6 putative polymerases exhibit strong sequence homology with the gag-specific protease (p15) of Rous sarcoma virus (RSV) as well as the amino acid sequence predicted from the gag/pol spacer sequence of human adult T-cell leukaemia virus (HTLV) [9].
  • Open reading frames for gag and pol genes were identified [10].
  • Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus [10].
  • The 5'-terminal half of the genomes (corresponding to the gag and pol regions) is virtually identical, with only scattered single nucleotide differences [11].
  • DNA sequencing of the pol-src junction of BH-RSV revealed that the env sequence was almost entirely absent; only six base pairs following the pol termination codon remained [12].

Anatomical context of pol

  • RNA analysis of nonproducer clones of RSV-29-infected chicken embryonic fibroblasts showed the presence of a subgenomic message of 2.6 kilobases containing src and a genomic RNA of 7.7 kilobases that contains gag, pol, and src, but not env [13].
  • A 2-base substitution which created a nonsense mutation in the pol reading frame and was predicted to disrupt the hairpin structure of the ribosome frameshift signal had no effect on particle assembly or Gag processing, definitively showing that downstream amino acids are unnecessary [14].
  • With the use of specific anti-RSV protein antisera, we found that only the viral gag and pol proteins were synthesized at levels similar to those synthesized in RSV-transformed fibroblasts; the synthesis of env and v-src proteins was significantly reduced in these infected myotubes [15].
  • Two cell lines, H-18 and H-20, have all the viral structural genes expressed, but a new EcoRI recognition site appeared in the region of the pol gene sequence [16].


  1. A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase. Oppermann, H., Bishop, J.M., Varmus, H.E., Levintow, L. Cell (1977) [Pubmed]
  2. Crystal structure of a retroviral protease proves relationship to aspartic protease family. Miller, M., Jaskólski, M., Rao, J.K., Leis, J., Wlodawer, A. Nature (1989) [Pubmed]
  3. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Jacks, T., Power, M.D., Masiarz, F.R., Luciw, P.A., Barr, P.J., Varmus, H.E. Nature (1988) [Pubmed]
  4. Major pol gene progenitors in the evolution of oncoviruses. Chiu, I.M., Callahan, R., Tronick, S.R., Schlom, J., Aaronson, S.A. Science (1984) [Pubmed]
  5. A new class of endogenous human retroviral genomes. Callahan, R., Chiu, I.M., Wong, J.F., Tronick, S.R., Roe, B.A., Aaronson, S.A., Schlom, J. Science (1985) [Pubmed]
  6. Nucleotide sequence of Rous sarcoma virus. Schwartz, D.E., Tizard, R., Gilbert, W. Cell (1983) [Pubmed]
  7. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Jacks, T., Varmus, H.E. Science (1985) [Pubmed]
  8. Human T-cell leukemia virus type 1 reverse transcriptase (RT) originates from the pro and pol open reading frames and requires the presence of RT-RNase H (RH) and RT-RH-integrase proteins for its activity. Trentin, B., Rebeyrotte, N., Mamoun, R.Z. J. Virol. (1998) [Pubmed]
  9. Close structural resemblance between putative polymerase of a Drosophila transposable genetic element 17.6 and pol gene product of Moloney murine leukaemia virus. Toh, H., Kikuno, R., Hayashida, H., Miyata, T., Kugimiya, W., Inouye, S., Yuki, S., Saigo, K. EMBO J. (1985) [Pubmed]
  10. Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus. Maurer, B., Bannert, H., Darai, G., Flügel, R.M. J. Virol. (1988) [Pubmed]
  11. Nucleotide sequence relationships between the genomes of an endogenous and an exogenous avian tumor virus. Coffin, J.M., Champion, M., Chabot, F. J. Virol. (1978) [Pubmed]
  12. DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains. Lerner, T.L., Hanafusa, H. J. Virol. (1984) [Pubmed]
  13. Partial nucleotide sequence of Rous sarcoma virus-29 provides evidence that the original Rous sarcoma virus was replication defective. Dutta, A., Wang, L.H., Hanafusa, T., Hanafusa, H. J. Virol. (1985) [Pubmed]
  14. Amino acids encoded downstream of gag are not required by Rous sarcoma virus protease during gag-mediated assembly. Bennett, R.P., Rhee, S., Craven, R.C., Hunter, E., Wills, J.W. J. Virol. (1991) [Pubmed]
  15. Infection of terminally differentiated myotubes with Rous sarcoma virus: reduced synthesis of env and v-src proteins. Hsia, K.J., Hara, H., Izutani, R., Park, H.T., Fujihara, M., Kaji, A. J. Gen. Virol. (1992) [Pubmed]
  16. Characterization of exogenous proviral sequences in hamster tumor cell lines transformed by Rous sarcoma virus rescued from XC cells. Svoboda, J., Lhoták, V., Geryk, J., Saule, S., Raes, M.B., Stehelin, D. Virology (1983) [Pubmed]
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