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Gene Review

LILRA2  -  leukocyte immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD85 antigen-like family member H, CD85H, CD85h, ILT-1, ILT1, ...
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Psychiatry related information on LILRA2


High impact information on LILRA2


Biological context of LILRA2

  • Furthermore, ILT1 and ILT2 are encoded on chromosome 19, as are Fc alphaR and KIR [6].
  • One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction [7].
  • Using the sequence data produced by the human genome project, we have developed a hypothesis that reconstructs the genesis of the two human ILT clusters in detail which will help to understand the function of the LRC [8].
  • A human cDNA clone cross-hybridizing to a murine p91 probe was isolated from a human spleen cDNA library, and was found to code for a molecule quite similar to members of the immunoglobulin-like transcript (or ILT) family [9].

Anatomical context of LILRA2


Associations of LILRA2 with chemical compounds

  • We identified LIR7, an activating member coupled to the common Fc receptor gamma chain, and LIR3, an inhibitory member containing cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, on these cells from human peripheral blood [14].
  • ILT1 has an arginine within the transmembrane region, followed by a short cytoplasmic tail, similar to human Fc alphaRI and bovine Fc gamma2R [6].

Physical interactions of LILRA2


Other interactions of LILRA2

  • We investigated the transcriptional regulation of ILT1, ILT2, and ILT4 genes to elucidate control mechanisms operating on the specific expression of ILT receptors [16].


  1. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Bleharski, J.R., Li, H., Meinken, C., Graeber, T.G., Ochoa, M.T., Yamamura, M., Burdick, A., Sarno, E.N., Wagner, M., Röllinghoff, M., Rea, T.H., Colonna, M., Stenger, S., Bloom, B.R., Eisenberg, D., Modlin, R.L. Science (2003) [Pubmed]
  2. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., Colonna, M. Nat. Med. (1999) [Pubmed]
  3. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. Allan, D.S., Colonna, M., Lanier, L.L., Churakova, T.D., Abrams, J.S., Ellis, S.A., McMichael, A.J., Braud, V.M. J. Exp. Med. (1999) [Pubmed]
  4. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. Cella, M., Döhring, C., Samaridis, J., Dessing, M., Brockhaus, M., Lanzavecchia, A., Colonna, M. J. Exp. Med. (1997) [Pubmed]
  5. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Tedla, N., Bandeira-Melo, C., Tassinari, P., Sloane, D.E., Samplaski, M., Cosman, D., Borges, L., Weller, P.F., Arm, J.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Samaridis, J., Colonna, M. Eur. J. Immunol. (1997) [Pubmed]
  7. Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain. Nakajima, H., Samaridis, J., Angman, L., Colonna, M. J. Immunol. (1999) [Pubmed]
  8. Genesis of the ILT/LIR/MIR clusters within the human leukocyte receptor complex. Volz, A., Wende, H., Laun, K., Ziegler, A. Immunol. Rev. (2001) [Pubmed]
  9. Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family. Yamashita, Y., Fukuta, D., Tsuji, A., Nagabukuro, A., Matsuda, Y., Nishikawa, Y., Ohyama, Y., Ohmori, H., Ono, M., Takai, T. J. Biochem. (1998) [Pubmed]
  10. Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules. Petroff, M.G., Sedlmayr, P., Azzola, D., Hunt, J.S. J. Reprod. Immunol. (2002) [Pubmed]
  11. The ILT family of leukocyte receptors. Allan, D.S., McMichael, A.J., Braud, V.M. Immunobiology (2000) [Pubmed]
  12. The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. Tedla, N., Gibson, K., McNeil, H.P., Cosman, D., Borges, L., Arm, J.P. Am. J. Pathol. (2002) [Pubmed]
  13. Tolerization of dendritic cells by HLA-G. Ristich, V., Liang, S., Zhang, W., Wu, J., Horuzsko, A. Eur. J. Immunol. (2005) [Pubmed]
  14. Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Sloane, D.E., Tedla, N., Awoniyi, M., Macglashan, D.W., Borges, L., Austen, K.F., Arm, J.P. Blood (2004) [Pubmed]
  15. Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex. Torkar, M., Norgate, Z., Colonna, M., Trowsdale, J., Wilson, M.J. Eur. J. Immunol. (1998) [Pubmed]
  16. Transcriptional regulation of ILT family receptors. Nakajima, H., Asai, A., Okada, A., Ping, L., Hamajima, F., Sata, T., Isobe, K. J. Immunol. (2003) [Pubmed]
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