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Gene Review

KIR3DL3  -  killer cell immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD158 antigen-like family member Z, CD158Z, CD158z, KIR3DL7, KIR44, ...
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Disease relevance of KIR3DL3


High impact information on KIR3DL3


Biological context of KIR3DL3


Anatomical context of KIR3DL3


Associations of KIR3DL3 with chemical compounds

  • KIR3DL3 has only one immunoreceptor tyrosine-based inhibitory motif and lacks the exon encoding the stem between the Immunoglobulin domains and the transmembrane region [13].

Regulatory relationships of KIR3DL3

  • Although this region had no impact on the activity of the KIR2DL3 promoter, an inhibitory element was identified in the KIR2DL4 promoter and an activating element was found in the KIR3DL3 promoter [11].

Other interactions of KIR3DL3


Analytical, diagnostic and therapeutic context of KIR3DL3


  1. Nature of allelic sequence polymorphism at the KIR3DL3 locus. Jones, D.C., Hiby, S.E., Moffett, A., Trowsdale, J., Young, N.T. Immunogenetics (2006) [Pubmed]
  2. TCR gamma delta cytotoxic T lymphocytes expressing the killer cell-inhibitory receptor p58.2 (CD158b) selectively lyse acute myeloid leukemia cells. Dolstra, H., Fredrix, H., van der Meer, A., de Witte, T., Figdor, C., van de Wiel-van Kemenade, E. Bone Marrow Transplant. (2001) [Pubmed]
  3. Increased expression of the natural killer cell inhibitory receptor CD94/NKG2A and CD158b on circulating and lesional T cells in patients with chronic plaque psoriasis. Liao, Y.H., Jee, S.H., Sheu, B.C., Huang, Y.L., Tseng, M.P., Hsu, S.M., Tsai, T.F. Br. J. Dermatol. (2006) [Pubmed]
  4. Characterization of gammadelta T cells expressing CD158b, a killer cell inhibitory receptor, in a patient with chronic CD4(+) lymphocytopenia and disseminated Mycobacterium intracellulare infection. Airò, P., Caruso, A., Stellini, R., Antonioli, C., Malacarne, F., Licenziati, S., Albertini, A., Cattaneo, R., Imberti, L. Clin. Immunol. (2000) [Pubmed]
  5. Aberrant expression of intercellular adhesion molecule-1 and killer inhibitory receptors induces immune tolerance in women with pelvic endometriosis. Maeda, N., Izumiya, C., Oguri, H., Kusume, T., Yamamoto, Y., Fukaya, T. Fertil. Steril. (2002) [Pubmed]
  6. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. Fan, Q.R., Mosyak, L., Winter, C.C., Wagtmann, N., Long, E.O., Wiley, D.C. Nature (1997) [Pubmed]
  7. Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor. Fan, Q.R., Wiley, D.C. J. Exp. Med. (1999) [Pubmed]
  8. The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. Rajagopalan, S., Long, E.O. J. Exp. Med. (1997) [Pubmed]
  9. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. D'Andrea, A., Chang, C., Phillips, J.H., Lanier, L.L. J. Exp. Med. (1996) [Pubmed]
  10. Natural killer cells and their role in graft rejection. Manilay, J.O., Sykes, M. Curr. Opin. Immunol. (1998) [Pubmed]
  11. Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. Trompeter, H.I., Gómez-Lozano, N., Santourlidis, S., Eisermann, B., Wernet, P., Vilches, C., Uhrberg, M. J. Immunol. (2005) [Pubmed]
  12. Detailed gene and allele content analysis of three homozygous KIR haplotypes. Murdoch, S., Seoud, M., Kircheisen, R., Mazhar, B., Slim, R. Tissue Antigens (2006) [Pubmed]
  13. Molecular characterization of KIR3DL3. Trundley, A.E., Hiby, S.E., Chang, C., Sharkey, A.M., Santourlidis, S., Uhrberg, M., Trowsdale, J., Moffett, A. Immunogenetics (2006) [Pubmed]
  14. Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule. Fan, Q.R., Garboczi, D.N., Winter, C.C., Wagtmann, N., Long, E.O., Wiley, D.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  15. Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex. Torkar, M., Norgate, Z., Colonna, M., Trowsdale, J., Wilson, M.J. Eur. J. Immunol. (1998) [Pubmed]
  16. Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor. Cambiaggi, A., Verthuy, C., Naquet, P., Romagné, F., Ferrier, P., Biassoni, R., Moretta, A., Moretta, L., Vivier, E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  17. Fas-independent apoptosis of T cells via killer cell inhibitory receptors. Nakajima, H., Yamada, N., Takiguchi, M. Int. Immunol. (1998) [Pubmed]
  18. Development of a PCR-SSOP approach capable of defining the natural killer cell inhibitory receptor (KIR) gene sequence repertoires. Crum, K.A., Logue, S.E., Curran, M.D., Middleton, D. Tissue Antigens (2000) [Pubmed]
  19. Sequential analysis of HLA-C-specific killer cell inhibitory receptor (CD158b) expressing peripheral blood mononuclear cells during chronic graft-versus-host disease. Tanaka, J., Tutumi, Y., Mori, A., Ohta, S., Kobayashi, S., Asaka, M., Imamura, M. Bone Marrow Transplant. (2000) [Pubmed]
  20. NKB1: a killer cell inhibitory receptor for class I HLA-B allotypes. D'Andrea, A., Lanier, L.L. Chem. Immunol. (1996) [Pubmed]
  21. Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. Dimasi, N., Moretta, A., Moretta, L., Biassoni, R., Mariuzza, R.A. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  22. CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Sivori, S., Vitale, M., Bottino, C., Marcenaro, E., Sanseverino, L., Parolini, S., Moretta, L., Moretta, A. Eur. J. Immunol. (1996) [Pubmed]
  23. Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction. Fauriat, C., Just-Landi, S., Mallet, F., Arnoulet, C., Sainty, D., Olive, D., Costello, R.T. Blood (2007) [Pubmed]
  24. Expression, crystallization and preliminary crystallographic analysis of the extracellular IgV-like domain of the human natural killer cell inhibitory receptor p75/AIRM1. Dimasi, N., Moretta, L., Biassoni, R., Mariuzza, R.A. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
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