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Gene Review

LILRB2  -  leukocyte immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD85 antigen-like family member D, CD85D, CD85d, ILT-4, ILT4, ...
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Disease relevance of LILRB2


High impact information on LILRB2


Biological context of LILRB2


Anatomical context of LILRB2


Physical interactions of LILRB2

  • ILT2 generally bound with a 2- to 3-fold higher affinity than ILT4 to the same MHCI [10].
  • Here, we report the 2.5-A resolution crystal structure of the LILRB2/HLA-G complex [5].

Regulatory relationships of LILRB2


Other interactions of LILRB2


Analytical, diagnostic and therapeutic context of LILRB2


  1. Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18. Willcox, B.E., Thomas, L.M., Chapman, T.L., Heikema, A.P., West, A.P., Bjorkman, P.J. BMC Struct. Biol. (2002) [Pubmed]
  2. Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals. Vlad, G., Piazza, F., Colovai, A., Cortesini, R., Della Pietra, F., Suciu-Foca, N., Manavalan, J.S. Hum. Immunol. (2003) [Pubmed]
  3. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Chang, C.C., Ciubotariu, R., Manavalan, J.S., Yuan, J., Colovai, A.I., Piazza, F., Lederman, S., Colonna, M., Cortesini, R., Dalla-Favera, R., Suciu-Foca, N. Nat. Immunol. (2002) [Pubmed]
  4. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. Allan, D.S., Colonna, M., Lanier, L.L., Churakova, T.D., Abrams, J.S., Ellis, S.A., McMichael, A.J., Braud, V.M. J. Exp. Med. (1999) [Pubmed]
  5. Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). Shiroishi, M., Kuroki, K., Rasubala, L., Tsumoto, K., Kumagai, I., Kurimoto, E., Kato, K., Kohda, D., Maenaka, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules. Petroff, M.G., Sedlmayr, P., Azzola, D., Hunt, J.S. J. Reprod. Immunol. (2002) [Pubmed]
  7. Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). Shiroishi, M., Kajikawa, M., Kuroki, K., Ose, T., Kohda, D., Maenaka, K. J. Biol. Chem. (2006) [Pubmed]
  8. Transcriptional regulation of ILT family receptors. Nakajima, H., Asai, A., Okada, A., Ping, L., Hamajima, F., Sata, T., Isobe, K. J. Immunol. (2003) [Pubmed]
  9. Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4. Papanikolaou, N.A., Vasilescu, E.R., Suciu-Foca, N. Hum. Immunol. (2004) [Pubmed]
  10. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Shiroishi, M., Tsumoto, K., Amano, K., Shirakihara, Y., Colonna, M., Braud, V.M., Allan, D.S., Makadzange, A., Rowland-Jones, S., Willcox, B., Jones, E.Y., van der Merwe, P.A., Kumagai, I., Maenaka, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  11. Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. Clements, C.S., Kjer-Nielsen, L., Kostenko, L., Hoare, H.L., Dunstone, M.A., Moses, E., Freed, K., Brooks, A.G., Rossjohn, J., McCluskey, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Human cytomegalovirus, MHC class I and inhibitory signalling receptors: more questions than answers. Cosman, D., Fanger, N., Borges, L. Immunol. Rev. (1999) [Pubmed]
  13. The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium. Tedla, N., Gibson, K., McNeil, H.P., Cosman, D., Borges, L., Arm, J.P. Am. J. Pathol. (2002) [Pubmed]
  14. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Fanger, N.A., Cosman, D., Peterson, L., Braddy, S.C., Maliszewski, C.R., Borges, L. Eur. J. Immunol. (1998) [Pubmed]
  15. Tetrameric complexes of HLA-E, HLA-F, and HLA-G. Allan, D.S., Lepin, E.J., Braud, V.M., O'Callaghan, C.A., McMichael, A.J. J. Immunol. Methods (2002) [Pubmed]
  16. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells. Gleissner, C.A., Zastrow, A., Klingenberg, R., Kluger, M.S., Konstandin, M., Celik, S., Haemmerling, S., Shankar, V., Giese, T., Katus, H.A., Dengler, T.J. Eur. J. Immunol. (2007) [Pubmed]
  17. Tolerization of dendritic cells by HLA-G. Ristich, V., Liang, S., Zhang, W., Wu, J., Horuzsko, A. Eur. J. Immunol. (2005) [Pubmed]
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