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Gene Review

DIDO1  -  death inducer-obliterator 1

Homo sapiens

Synonyms: BYE1, C20orf158, DATF-1, DATF1, DIDO2, ...
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Disease relevance of DIDO1


High impact information on DIDO1


Biological context of DIDO1

  • Despite the transcriptional response to T3, no functional thyroid response elements were identified in the 1.5-kilobase 5'-flanking region of either the C57 or C3H dio1 gene [7].
  • At Harwell, we have progressed from designing, building, and using small-diameter beams of epithermal neutrons for radiobiology studies to designing a radiotherapy facility for the 25-MW research reactor DIDO [8].

Associations of DIDO1 with chemical compounds

  • These results lead to the conclusions that DATFP-FPP is an effective probe of the prenyl diphosphate binding domains of PFT and PGGT-I [9].
  • A putative geranylgeranyl diphosphate analogue, 2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate (DATFP-FPP), was the best inhibitor of both protein farnesyltransferase (PFT) and protein geranylgeranyltransferase-I (PFFT-I) [9].

Analytical, diagnostic and therapeutic context of DIDO1


  1. Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. Maia, A.L., Berry, M.J., Sabbag, R., Harney, J.W., Larsen, P.R. Mol. Endocrinol. (1995) [Pubmed]
  2. Comparison of two 2,3-diacyl trehalose antigens from Mycobacterium tuberculosis and Mycobacterium fortuitum for serology in tuberculosis patients. Tórtola, M.T., Lanéelle, M.A., Martín-Casabona, N. Clin. Diagn. Lab. Immunol. (1996) [Pubmed]
  3. Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. Fütterer, A., Campanero, M.R., Leonardo, E., Criado, L.M., Flores, J.M., Hernández, J.M., San Miguel, J.F., Martínez-A, C. J. Clin. Invest. (2005) [Pubmed]
  4. The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. Alenghat, T., Yu, J., Lazar, M.A. EMBO J. (2006) [Pubmed]
  5. DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. García-Domingo, D., Leonardo, E., Grandien, A., Martínez, P., Albar, J.P., Izpisúa-Belmonte, J.C., Martínez-A, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. Death inducer-obliterator 1 triggers apoptosis after nuclear translocation and caspase upregulation. García-Domingo, D., Ramírez, D., González de Buitrago, G., Martínez-A, C. Mol. Cell. Biol. (2003) [Pubmed]
  7. Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice. Maia, A.L., Kieffer, J.D., Harney, J.W., Larsen, P.R. Endocrinology (1995) [Pubmed]
  8. Neutron capture therapy beam design at Harwell. Constantine, G. Basic Life Sci. (1990) [Pubmed]
  9. Photoreactive analogues of prenyl diphosphates as inhibitors and probes of human protein farnesyltransferase and geranylgeranyltransferase type I. Bukhtiyarov, Y.E., Omer, C.A., Allen, C.M. J. Biol. Chem. (1995) [Pubmed]
  10. Death inducer obliterator protein 1 in the context of DNA regulation. Sequence analyses of distant homologues point to a novel functional role. Rojas, A.M., Sanchez-Pulido, L., Fütterer, A., van Wely, K.H., Martinez-A, C., Valencia, A. FEBS J. (2005) [Pubmed]
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