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Disease relevance of Radiobiology


High impact information on Radiobiology

  • Radiation biology. Alpha-particle after effects [4].
  • The iron chelator desferrioxamine (DFO), which diminishes oxidative damage in many chemical and biological systems as well as in human subjects, has a controversial role in radiobiology and reportedly acts both as a radiosensitizer and a radioprotector [5].
  • Molecular aspects of tritiated water and natural water in radiation biology [6].
  • N,'N'1,3-bis(trans-4-hydroxycyclohexyl)-N'-nitrosoureas (BCyNU), a nitrosourea reported to selectively inhibit glutathione reductase (GR) activity, was examined to determine if it could be used as a means to inhibit cellular levels of this enzyme in radiobiology studies [7].
  • Clinical radiobiology of stage T2-T3 bladder cancer [8].

Biological context of Radiobiology


Anatomical context of Radiobiology


Associations of Radiobiology with chemical compounds


Gene context of Radiobiology

  • It is a generally accepted principle of radiation biology that hematopoietic progenitor cells demonstrate dose rate independent killing by x-irradiation over the clinically relevant range for total body irradiation (TBI) (5-25 rad/min) [21].
  • In Method 2, "classic" radiobiology dictates that a typical course of breast RT and PCI results in approximately =7 and approximately =4.5 log of cell kill, respectively [22].
  • Educational materials are available on the ACR, ASTRO, and RRS websites, linked to the Armed Forces Radiobiology Research Institute and the Oak Ridge National Laboratory, to provide radiation workers material that they can use to help emergency room and civil defense personnel after a terrorist attack [23].
  • To date radiobiology experiments in this energy region have relied on characteristic X-rays (mainly Alk and Ck) from X-ray tubes [24].
  • Experimental work and radiation biology is reviewed and it is suggested that the risk of thyroid cancer from the usual radio-iodine doses given for treatment is low because of cell killing or sterilization, and animal evidence is discussed that supports this [25].

Analytical, diagnostic and therapeutic context of Radiobiology


  1. The ATM gene and the radiobiology of ataxia-telangiectasia. Jorgensen, T.J., Shiloh, Y. Int. J. Radiat. Biol. (1996) [Pubmed]
  2. The use of models in "target" theory to evaluate the survival curves of human ovarian carcinoma cell line exposure to adriamycin combined with ultrasound. Yu, T., Xiong, Z., Chen, S., Tu, G. Ultrasonics sonochemistry. (2005) [Pubmed]
  3. A purpose-built iodine-125 irradiation plaque for low dose rate low energy irradiation of cell lines in vitro. Aird, E.G., Folkard, M., Mayes, C.R., Bownes, P.J., Lawson, J.M., Joiner, M.C. The British journal of radiology. (2001) [Pubmed]
  4. Radiation biology. Alpha-particle after effects. Evans, H.J. Nature (1992) [Pubmed]
  5. The use of Zn-desferrioxamine for radioprotection in mice, tissue culture, and isolated DNA. Samuni, Y., Coffin, D., DeLuca, A.M., DeGraff, W.G., Venson, D.J., Ambudkar, I., Chevion, M., Mitchell, J.B. Cancer Res. (1999) [Pubmed]
  6. Molecular aspects of tritiated water and natural water in radiation biology. Mathur-De Vré, R., Binet, J. Prog. Biophys. Mol. Biol. (1984) [Pubmed]
  7. Inhibition of glutathione reductase activity by a carbamoylating nitrosourea: effect on cellular radiosensitivity. Miller, A.C., Blakely, W.F. Free Radic. Biol. Med. (1992) [Pubmed]
  8. Clinical radiobiology of stage T2-T3 bladder cancer. Majewski, W., Maciejewski, B., Majewski, S., Suwinski, R., Miszczyk, L., Tarnawski, R. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  9. The response of spontaneous and transplantable murine tumors to vasoactive agents measured by 31P magnetic resonance spectroscopy. Wood, P.J., Stratford, I.J., Sansom, J.M., Cattanach, B.M., Quinney, R.M., Adams, G.E. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  10. The application of rapid-lysis techniques in radiobiology. IV. The effect of glycerol and DMSO on Chinese hamster cell survival and DNA single-strand break production. Millar, B.C., Sapora, O., Fielden, E.M., Loverock, P.S. Radiat. Res. (1981) [Pubmed]
  11. Tritium radiobiology and relative biological effectiveness. Straume, T., Carsten, A.L. Health physics. (1993) [Pubmed]
  12. The radiobiology of 24 keV neutrons. Measurement of the relative biological effect free-in-air, survival and cytogenetic analysis of the biological effect at various depths in a polyethylene phantom and modification of the depth-dose profile by boron 10 for V79 Chinese hamster and HeLa cells. Morgan, G.R., Mill, A.J., Roberts, C.J., Newman, S., Holt, P.D. The British journal of radiology. (1988) [Pubmed]
  13. 3-D confocal microscopy of etched nuclear tracks in CR-39. Fromm, M., Vaginay, F., Pusset, D., Meesen, G., Chambaudet, A., Poffijn, A. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB). (2001) [Pubmed]
  14. Recombinant murine GM-CSF increases resistance of some factor dependent hematopoietic progenitor cells to low-dose-rate gamma irradiation. FitzGerald, T.J., Henault, S., Santucci, M.A., Anklesaria, P., Zak, S., Kase, K., Farber, N., Pierce, J.H., Ohara, A., Greenberger, J.S. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  15. Radiosensitivity of human bone marrow granulocyte-macrophage progenitor cells and stromal colony-forming cells: effect of dose rate. FitzGerald, T.J., McKenna, M., Rothstein, L., Daugherty, C., Kase, K., Greenberger, J.S. Radiat. Res. (1986) [Pubmed]
  16. Cancer Research Campaign review of radiobiology research. Horwich, A. Br. J. Cancer (1993) [Pubmed]
  17. The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor. Chaplin, D.J., Durand, R.E., Stratford, I.J., Jenkins, T.C. Int. J. Radiat. Oncol. Biol. Phys. (1986) [Pubmed]
  18. Radiobiology and clinical application of halogenated pyrimidine radiosensitizers. Mitchell, J.B., Russo, A., Cook, J.A., Straus, K.L., Glatstein, E. Int. J. Radiat. Biol. (1989) [Pubmed]
  19. The in vitro radiobiology of astatine-211 decay. Kassis, A.I., Harris, C.R., Adelstein, S.J., Ruth, T.J., Lambrecht, R., Wolf, A.P. Radiat. Res. (1986) [Pubmed]
  20. Increase in intracellular cysteine after exposure to dithiothreitol: implications in radiobiology. Dennis, M.F., Stratford, M.R., Wardman, P., Watfa, R.R. Int. J. Radiat. Biol. (1989) [Pubmed]
  21. Effect of X-irradiation dose rate on the clonagenic survival of human and experimental animal hematopoietic tumor cell lines: evidence for heterogeneity. FitzGerald, T.J., McKenna, M., Kase, K., Daugherty, C., Rothstein, L., Greenberger, J.S. Int. J. Radiat. Oncol. Biol. Phys. (1986) [Pubmed]
  22. Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data. Kirkpatrick, J.P., Marks, L.B. Int. J. Radiat. Oncol. Biol. Phys. (2004) [Pubmed]
  23. Radiation scientists and homeland security. Rose, C.M. Radiat. Res. (2002) [Pubmed]
  24. Synchrotron-produced ultrasoft X-rays: a tool for testing biophysical models of radiation action. Meger Wells, C.M., Pearson, D.W., De Luca, P.M., Wells, G.M., Cerrina, F., Kennan, W.S., Gould, M.N. Int. J. Radiat. Biol. (1991) [Pubmed]
  25. Radio-iodine treatment of hyperthyroidism--a more liberal policy? Halnan, K.E. Clinics in endocrinology and metabolism. (1985) [Pubmed]
  26. Analysis of the radiobiology of ytterbium-169 and iodine-125 permanent brachytherapy implants. Lazarescu, G.R., Battista, J.J. Physics in medicine and biology. (1997) [Pubmed]
  27. The potential of californium-252 in radiotherapy. Preclinical measurements in physics and radiobiology. Hall, E.J., Rossi, H. The British journal of radiology. (1975) [Pubmed]
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