Disease relevance of Radiobiology

• The ATM gene and the radiobiology of ataxia-telangiectasia [1].
• The models of "target" theory in radiation biology were used to evaluate the survival curves of human ovarian carcinoma cell line after exposure to adriamycin combined with ultrasound [2].
• To investigate the radiobiology of hypersensitivity of this type on various cell lines in vitro, an iodine-125 seed irradiator has been designed and built for safe use in the Gray Laboratory. In practice, the calculated dose rate has been used for consistency [3].

High impact information on Radiobiology

• Radiation biology. Alpha-particle after effects [4].
• The iron chelator desferrioxamine (DFO), which diminishes oxidative damage in many chemical and biological systems as well as in human subjects, has a controversial role in radiobiology and reportedly acts both as a radiosensitizer and a radioprotector [5].
• Molecular aspects of tritiated water and natural water in radiation biology [6].
• N,'N'1,3-bis(trans-4-hydroxycyclohexyl)-N'-nitrosoureas (BCyNU), a nitrosourea reported to selectively inhibit glutathione reductase (GR) activity, was examined to determine if it could be used as a means to inhibit cellular levels of this enzyme in radiobiology studies [7].
• Clinical radiobiology of stage T2-T3 bladder cancer [8].

Biological context of Radiobiology

• 31P magnetic resonance spectroscopy has been used to compare the effects of the vasoactive agents hydralazine and flunarizine on the oxygenation of the transplantable tumors, SCCVII/Ha and 16C, and a range of spontaneous mammary tumors arising in the breeding stock in the Genetics Division at the Radiobiology Unit [9].
• The application of rapid-lysis techniques in radiobiology. IV. The effect of glycerol and DMSO on Chinese hamster cell survival and DNA single-strand break production [10].
• Tritium radiobiology and relative biological effectiveness [11].
• The radiobiology of 24 keV neutrons. Measurement of the relative biological effect free-in-air, survival and cytogenetic analysis of the biological effect at various depths in a polyethylene phantom and modification of the depth-dose profile by boron 10 for V79 Chinese hamster and HeLa cells [12].
• Solid State Nuclear Track Detectors (SSNTD's) are used in a wide range of applications such as Geological Dating, Environmental Sciences (radon), life Sciences (Radiobiology, Dosimetry...), as well as Nuclear and Astro-Physics [13].

Anatomical context of Radiobiology

• The effects of murine recombinant IL-3 (multi-CSF) and murine recombinant GM-CSF (granulocyte-macrophage colony stimulating factor) on the radiation biology of clonal hematopoietic progenitor cell lines were evaluated [14].
• Study of the radiation biology of human bone marrow hematopoietic cells has been difficult since unseparated bone marrow cell preparations also contain other nonhematopoietic stromal cells [15].

Associations of Radiobiology with chemical compounds

• Cancer Research Campaign review of radiobiology research [16].
• RSU-1069 is one of a group of compounds of particular interest in radiobiology, since it combines the nitroimidazole ring with a side chain bearing a monofunctional alkylating agent [17].
• Radiobiology and clinical application of halogenated pyrimidine radiosensitizers [18].
• The in vitro radiobiology of astatine-211 decay [19].
• Increase in intracellular cysteine after exposure to dithiothreitol: implications in radiobiology [20].

Gene context of Radiobiology

• It is a generally accepted principle of radiation biology that hematopoietic progenitor cells demonstrate dose rate independent killing by x-irradiation over the clinically relevant range for total body irradiation (TBI) (5-25 rad/min) [21].
• In Method 2, "classic" radiobiology dictates that a typical course of breast RT and PCI results in approximately =7 and approximately =4.5 log of cell kill, respectively [22].
• Educational materials are available on the ACR, ASTRO, and RRS websites, linked to the Armed Forces Radiobiology Research Institute and the Oak Ridge National Laboratory, to provide radiation workers material that they can use to help emergency room and civil defense personnel after a terrorist attack [23].
• To date radiobiology experiments in this energy region have relied on characteristic X-rays (mainly Alk and Ck) from X-ray tubes [24].
• Experimental work and radiation biology is reviewed and it is suggested that the risk of thyroid cancer from the usual radio-iodine doses given for treatment is low because of cell killing or sterilization, and animal evidence is discussed that supports this [25].

Analytical, diagnostic and therapeutic context of Radiobiology

• Analysis of the radiobiology of ytterbium-169 and iodine-125 permanent brachytherapy implants [26].
• The potential of californium-252 in radiotherapy. Preclinical measurements in physics and radiobiology [27].

References