The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hyperthyroxinemia


High impact information on Hyperthyroxinemia


Chemical compound and disease context of Hyperthyroxinemia


Biological context of Hyperthyroxinemia


Anatomical context of Hyperthyroxinemia


Gene context of Hyperthyroxinemia

  • In a family expressing euthyroid hyperthyroxinemia, an increased association of plasma thyroxine (T4) with transthyretin (TTR) is transmitted by autosomal dominant inheritance and is secondary to a mutant TTR molecule with increased affinity for T4 [7].
  • SCID-TH from GD and HT patients showed transient hyperthyroxinemia, peaking at 2 weeks; these values were significantly higher [free T4, 6.48 +/- 0.90 and 5.50 +/- 0.77 pmol/L (mean +/- SE), respectively; P < 0.05] than SCID-TH from normal controls (2.5 +/- 0.24) [4].
  • Immunization with the extracellular domain of TSH receptor (TSHR) led to the development of hyperthyroxinemia in BALB/cJ, but not C57BL/6J, SJL/J, and B10.BR, mice [20].
  • Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass [20].
  • We hypothesize that hyperthyroxinemia may decrease GH secretion, both increasing somatostatin tone and acting directly at the pituitary level [21].


  1. Euthyroid familial hyperthyroxinemia due to abnormal thyroid hormone-binding protein. Borst, G.C., Premachandra, B.N., Burman, K.D., Osburne, R.C., Georges, L.P., Johnsonbaugh, R.E. Am. J. Med. (1982) [Pubmed]
  2. Specific methods to identify plasma binding abnormalities in euthyroid hyperthyroxinemia. Stockigt, J.R., Dyer, S.A., Mohr, V.S., White, E.L., Barlow, J.W. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  3. Thyroxine interactions with transthyretin: a comparison of 10 different naturally occurring human transthyretin variants. Rosen, H.N., Moses, A.C., Murrell, J.R., Liepnieks, J.J., Benson, M.D. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  4. Studies of thyroid xenografts from Graves' disease in severe combined immunodeficient mice. Morita, T., Yoshikawa, N., Akasu, F., Resetkova, E., Arreaza, G., Miller, N., Jamieson, C., Volpé, R. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  5. Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. Heufelder, A.E., Klee, G.G., Wynne, A.G., Gharib, H. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. (1995) [Pubmed]
  6. Familial euthyroid hyperthyroxinemia resulting from increased thyroxine binding to thyroxine-binding prealbumin. Moses, A.C., Lawlor, J., Haddow, J., Jackson, I.M. N. Engl. J. Med. (1982) [Pubmed]
  7. A point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. Moses, A.C., Rosen, H.N., Moller, D.E., Tsuzaki, S., Haddow, J.E., Lawlor, J., Liepnieks, J.J., Nichols, W.C., Benson, M.D. J. Clin. Invest. (1990) [Pubmed]
  8. Familial resistance to thyroid hormone associated with decreased transport across the plasma membrane. Wortsman, J., Premachandra, B.N., Williams, K., Burman, K.D., Hay, I.D., Davis, P.J. Ann. Intern. Med. (1983) [Pubmed]
  9. Thyroxine-binding globulin, hyperthyroxinemia and hepatocellular carcinoma. Kew, M.C. Hepatology (1991) [Pubmed]
  10. Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. Maia, A.L., Berry, M.J., Sabbag, R., Harney, J.W., Larsen, P.R. Mol. Endocrinol. (1995) [Pubmed]
  11. Familial hyperthyroxinemia due to abnormal thyroid hormone binding. Silverberg, J.D., Premachandra, B.N. Ann. Intern. Med. (1982) [Pubmed]
  12. Propranolol-induced hyperthyroxinemia. Mooradian, A., Morley, J.E., Simon, G., Shafer, R.B. Arch. Intern. Med. (1983) [Pubmed]
  13. Serum sex hormone-binding globulin in amiodarone-treated patients. A marker for tissue thyrotoxicosis. Bambini, G., Aghini-Lombardi, F., Rosner, W., Khan, M.S., Martino, E., Pinchera, A., Braverman, L.E., Safran, M. Arch. Intern. Med. (1987) [Pubmed]
  14. Thyroxine binding in a TTR Met 119 kindred. Alves, I.L., Divino, C.M., Schussler, G.C., Altland, K., Almeida, M.R., Palha, J.A., Coelho, T., Costa, P.P., Saraiva, M.J. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  15. The thyroxine-binding proteins. Schussler, G.C. Thyroid (2000) [Pubmed]
  16. Increased urinary excretion of sulfated 3,3',5-triiodothyronine in patients with nodular goiters receiving suppressive thyroxine therapy. Huang, W.S., Kuo, S.W., Chen, W.L., Fuh, M.M., Wu, S.Y. Thyroid (1996) [Pubmed]
  17. Euthyroid hyperthyroxinemia and thyroxine-binding prealbumin excess in islet cell carcinoma. Rajatanavin, R., Liberman, C., Lawrence, G.D., D'Arcangues, C.M., Young, R.A., Emerson, C.H. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  18. The effect of in vivo thyroxine treatment on insulin receptors, glucose transport and GLUT4 in rat adipocytes. Fickova, M., Zorad, S., Macho, L. Horm. Metab. Res. (1997) [Pubmed]
  19. Etiology and outcome of non-estrogen associated hyperthyroxinemia in euthyroid patients at the San Juan City Hospital. Alegre, M., Meléndez, E.G., Colón, G. Boletín de la Asociación Médica de Puerto Rico. (1996) [Pubmed]
  20. Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. Wagle, N.M., Patibandla, S.A., Dallas, J.S., Morris, J.C., Prabhakar, B.S. Endocrinology (1995) [Pubmed]
  21. Effect of arginine on the GHRH-stimulated GH secretion in patients with hyperthyroidism. Giustina, A., Schettino, M., Bussi, A.R., Legati, F., Licini, M., Zuccato, F., Wehrenberg, W.B. Horm. Res. (1992) [Pubmed]
WikiGenes - Universities