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Gene Review

Ankh  -  ANKH inorganic pyrophosphate transport...

Rattus norvegicus

Synonyms: ANK, Ank, Progressive ankylosis protein homolog
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High impact information on Ank


Anatomical context of Ank

  • In this study, we demonstrate that Ank is expressed primarily in human brain neurons, with the highest levels of expression observed in the thalamus, the III and V cortical layers, the Purkinje cells of the cerebellum, clusters of cells in the dorsal portion of the pons and midbrain, and neurons of the anterior horn of the spinal cord [2].

Associations of Ank with chemical compounds

  • Ank is a 492-amino acid multipass transmembrane protein involved in the regulation of extracellular inorganic pyrophosphate levels and the control of tissue calcification [2].

Analytical, diagnostic and therapeutic context of Ank

  • Previous Northern blot hybridization experiments revealed that Ank mRNA was expressed in the brain, but there have been no reports describing the anatomical sites or specific cell types in the brain that express Ank protein [2].


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