The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ank  -  progressive ankylosis

Mus musculus

Synonyms: Ankh, D15Ertd221e, Fn54 protein, Progressive ankylosis protein, ank, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ank


High impact information on Ank


Chemical compound and disease context of Ank


Biological context of Ank


Anatomical context of Ank


Associations of Ank with chemical compounds


Regulatory relationships of Ank


Other interactions of Ank

  • Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone [11].

Analytical, diagnostic and therapeutic context of Ank


  1. Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. Johnson, K., Goding, J., Van Etten, D., Sali, A., Hu, S.I., Farley, D., Krug, H., Hessle, L., Millán, J.L., Terkeltaub, R. J. Bone Miner. Res. (2003) [Pubmed]
  2. Progressive ankylosis, a new skeletal mutation in the mouse. Sweet, H.O., Green, M.C. J. Hered. (1981) [Pubmed]
  3. Progressive ankylosis in mice. An animal model of spondylarthropathy. I. Clinical and radiographic findings. Mahowald, M.L., Krug, H., Taurog, J. Arthritis Rheum. (1988) [Pubmed]
  4. Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. Kozlenkov, A., Le Du, M.H., Cuniasse, P., Ny, T., Hoylaerts, M.F., Millán, J.L. J. Bone Miner. Res. (2004) [Pubmed]
  5. HLA-B27 has no effect on the phenotypic expression of progressive ankylosis in ank/ank mice. Krug, H.E., Taurog, J.D. J. Rheumatol. (2000) [Pubmed]
  6. Role of the mouse ank gene in control of tissue calcification and arthritis. Ho, A.M., Johnson, M.D., Kingsley, D.M. Science (2000) [Pubmed]
  7. Biochemical and genetic analysis of ANK in arthritis and bone disease. Gurley, K.A., Reimer, R.J., Kingsley, D.M. Am. J. Hum. Genet. (2006) [Pubmed]
  8. Spondyloarthropathy in progressive ankylosis mice: ultrastructural features of the intervertebral disk. Sampson, H.W., Davis, R.W., Dufner, D.C. Acta anatomica. (1991) [Pubmed]
  9. P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells. Zaka, R., Stokes, D., Dion, A.S., Kusnierz, A., Han, F., Williams, C.J. Arthritis Res. Ther. (2006) [Pubmed]
  10. Phosphocitrate prevents disease progression in murine progressive ankylosis. Krug, H.E., Mahowald, M.L., Halverson, P.B., Sallis, J.D., Cheung, H.S. Arthritis Rheum. (1993) [Pubmed]
  11. Developmental and TGF-beta-mediated regulation of Ank mRNA expression in cartilage and bone. Sohn, P., Crowley, M., Slattery, E., Serra, R. Osteoarthr. Cartil. (2002) [Pubmed]
  12. Cementum: a phosphate-sensitive tissue. Nociti, F.H., Berry, J.E., Foster, B.L., Gurley, K.A., Kingsley, D.M., Takata, T., Miyauchi, M., Somerman, M.J. J. Dent. Res. (2002) [Pubmed]
  13. Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Harmey, D., Hessle, L., Narisawa, S., Johnson, K.A., Terkeltaub, R., Millán, J.L. Am. J. Pathol. (2004) [Pubmed]
  14. Hereditary joint disorder in progressive ankylosis (ank/ank) mice. I. Association of calcium hydroxyapatite deposition with inflammatory arthropathy. Hakim, F.T., Cranley, R., Brown, K.S., Eanes, E.D., Harne, L., Oppenheim, J.J. Arthritis Rheum. (1984) [Pubmed]
  15. Hereditary joint disorder in progressive ankylosis (ank/ank) mice. II. Effect of high-dose hydrocortisone treatment on inflammation and intraarticular calcium hydroxyapatite deposits. Hakim, F.T., Brown, K.S., Oppenheim, J.J. Arthritis Rheum. (1986) [Pubmed]
  16. Transient inhibition of murine progressive ankylosis by indomethacin. Krug, H.E., Mahowald, M.L. Agents Actions (1991) [Pubmed]
  17. Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess. Johnson, K., Terkeltaub, R. Osteoarthr. Cartil. (2004) [Pubmed]
  18. Progressive ankylosis (ank/ank) in mice: an animal model of spondyloarthropathy. II. Light and electron microscopic findings. Mahowald, M.L., Krug, H., Halverson, P. J. Rheumatol. (1989) [Pubmed]
WikiGenes - Universities