Disease relevance of C1QTNF3

• Therefore, a human bone tumor cDNA panel was investigated and a strong CORS-26 mRNA expression was found in osteosarcoma, chondroblastoma and giant cell tumor [1].

High impact information on C1QTNF3

• Transfection analysis suggested that CORS26 is a secretory protein [2].
• However, CORS26 mRNA were undetectable in mature chondrocytes [2].
• CORS26 mRNA was not detected in NIH3T3 cells, BALB/3T3 cells, C3H10T1/2 cells, or osteoblastic MC3T3-E1 cells by reverse transcription-polymerase chain reaction analysis [2].
• Northern blot analysis revealed that CORS26 mRNA was present at high levels in rib growth plate cartilage and at moderate levels in kidney of adult mice [2].
• In situ hybridization of mouse embryos between 13 and 15 days postcoitus revealed relatively high levels of CORS26 mRNA in condensed prechondrocytic cells of cartilage primordia and developing cartilages [2].

Biological context of C1QTNF3

• Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein) [1].
• The murine gene for CORS-26 is located on mouse chromosome 15A2 and its expression has been reported to be restricted to fibroblasts, cartilage and kidney [1].
• The chromosomal localization of the human CORS-26 gene was mapped to human chromosome 5p by fluorescence in situ hybridization (FISH) [1].

Anatomical context of C1QTNF3

• Northern blot analysis using a human multiple-tissue cDNA panel demonstrated expression of human CORS-26 mRNA in colon and small intestine [1].
• Furthermore CORS-26 protein was detected in human monocytic and dendritic cells [3].

Other interactions of C1QTNF3

• The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells [3].

Analytical, diagnostic and therapeutic context of C1QTNF3

• Additionally, RT-PCR analysis revealed expression of CORS-26 mRNA in placenta, fibroblasts and white adipose tissue [1].
• Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development [2].

References