Disease relevance of Nup107

• Only by using antisera obtained from rats bearing XC-cells induced tumors, two proteins were identified with an apparent molecular weight (Mr) of 105 000 (p105) and 98 000 (p98) and an isoelectric point of 6.4 and 6.2, respectively, in extracts of mammalian cells transformed by avian sarcoma viruses (ASV) [1].

High impact information on Nup107

• Activation of p50 was associated with a decrease of p105, generation of p50, and increased phosphorylation and degradation of IkappaB-alpha [2].
• Nup107 is a novel nuclear pore complex protein that contains a leucine zipper [3].
• In lysed PC12 cells, p113, p105, p86, and p84 were phosphorylated at serine residues by an endogenous protein kinase using [32P] ATP [4].
• Peptide mapping after limited proteolysis indicated sequence homologies between p113 and p105, and between p86 and p84 [4].
• These findings revealed that some mutations (N107P, N107S, V207T, G371M, and Q480G) not only improved the ability of CYP3A9 to hydroxylate testosterone at the 6beta and 2beta positions, but also converted it into a robust progesterone 6beta, 21-dihydroxylase [5].

Biological context of Nup107

• Therefore, the p60 Src kinase and the p105 kinase, referred to as "Src kinase kinase', may be involved in [Ca2+]o-dependent pancreatic exocytosis [6].
• The level of cell cycle exit markers Rb/p105 and Rb2/p130 gradually decreases after injury [7].

Associations of Nup107 with chemical compounds

• In intact PC12 cells labeled with inorganic [35S]sulfate, the major protein substrates for sulfation on tyrosine were four acidic polypeptides with apparent molecular weights of 113,000, 105,000, 86,000, and 84,000 designated as p113, p105, p86, and p84 [4].

Analytical, diagnostic and therapeutic context of Nup107

• The NF-kappa B family members p50, p65, p52, c-Rel, and RelB as well as the inhibitor proteins I kappa B alpha, I kappa B beta, and p105 were present in uninjured arteries as determined by immunoblotting [8].
• Northern blot analysis revealed a marked increase in the mRNA levels of p105, a precursor of p50, 6 h after TNF-alpha and a gradual increase in p65 mRNA levels during the initial 1 h [9].

References