High impact information on Scg3

• 1B1075 transcripts are detected, by blotting and in situ hybridization, at the highest levels in the neocortex, hippocampus, cerebellar cortex, selected pontine and diencephalic nuclei, and presumptive pituitary corticotrophs, at lower levels in specific nuclei in most other brain regions, but in none of several other tissues [1].
• With depletion of cholesterol from the SGM using methyl-beta-cyclodextrin, SgIII was impaired to bind to the SGM [2].
• Instead, CgA bound to the SGM-type liposome only in the presence of SgIII [2].
• Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules [3].
• These lines of evidence suggest that SgIII and CgB are closely associated with the secretory granule membrane and that this membrane association might contribute to gathering and anchoring of other soluble constituents to the secretory granule membrane [4].

Anatomical context of Scg3

• Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats [5].
• By light microscopy of semithin sections, the immunoreactivity for SgIII was readily detected in pancreatic A- and B-cells, faintly so in D-cells, and not at all in the exocrine pancreas [5].
• Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands [4].

Physical interactions of Scg3

• Secretogranin III was able to bind the aggregated form of chromogranin A, suggesting that a small quantity of secretogranin III is enough to carry a large quantity of chromogranin A [6].

Other interactions of Scg3

• Moreover, positive signals for SgIII were occasionally found in cells containing both prolactin and TSH in secretory granules [4].

Analytical, diagnostic and therapeutic context of Scg3

• By immunoelectron microscopy, immunogold particles indicative of SgIII were observed in the peripheral regions of secretory granules, and universally in the pancreatic endocrine cells [5].
• By immunohistochemistry using semithin sections, positive signals for SgIII were detected intensely in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, but not in somatotropes [4].

References