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Gene Review

Cpe  -  carboxypeptidase E

Rattus norvegicus

Synonyms: CARBE, CPE, CPH, Carboxypeptidase E, Carboxypeptidase H, ...
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Chemical compound and disease context of Cpe


Biological context of Cpe


Anatomical context of Cpe


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Analytical, diagnostic and therapeutic context of Cpe


  1. Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization. MacCumber, M.W., Snyder, S.H., Ross, C.A. J. Neurosci. (1990) [Pubmed]
  2. Altered expression of the neuropeptide-processing enzyme carboxypeptidase E in the rat brain after global ischemia. Jin, K., Graham, S.H., Nagayama, T., Goldsmith, P.C., Greenberg, D.A., Zhou, A., Simon, R.P. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  3. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Guest, P.C., Ravazzola, M., Davidson, H.W., Orci, L., Hutton, J.C. Endocrinology (1991) [Pubmed]
  4. Regulation of carboxypeptidase E by membrane depolarization in PC12 pheochromocytoma cells: comparison with mRNAs encoding other peptide- and catecholamine-biosynthetic enzymes. Das, B., Sabban, E.L., Kilbourne, E.J., Fricker, L.D. J. Neurochem. (1992) [Pubmed]
  5. Reflex splanchnic nerve stimulation increases levels of carboxypeptidase E mRNA and enzymatic activity in the rat adrenal medulla. Fricker, L.D., Rigual, R.J., Diliberto, E.J., Viveros, O.H. J. Neurochem. (1990) [Pubmed]
  6. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats. Liao, Y., Wang, R., Tang, X.C. Acta Pharmacol. Sin. (2004) [Pubmed]
  7. Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons. Lynch, D.R., Strittmatter, S.M., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  8. Domains of the rat rDNA promoter must be aligned stereospecifically. Xie, W.Q., Rothblum, L.I. Mol. Cell. Biol. (1992) [Pubmed]
  9. Light and dark cause a shift in the spatial expression of a neuropeptide-processing enzyme in the rat retina. Schlamp, C.L., Nickells, R.W. J. Neurosci. (1996) [Pubmed]
  10. Carboxypeptidase E (CPE): immunocytochemical localization in the rat central nervous system and pituitary gland. Lynch, D.R., Braas, K.M., Hutton, J.C., Snyder, S.H. J. Neurosci. (1990) [Pubmed]
  11. Decreased expression of carboxypeptidase E protein is correlated to estrogen-induction of rat pituitary tumors. Gregg, D., Goedken, E., Gaikin, M., Wendell, D., Gorski, J. Mol. Cell. Endocrinol. (1996) [Pubmed]
  12. Morphometric studies on synapses of the cerebellar glomerulus: the effect of centrophenoxine treatment in old rats. Giuli, C., Bertoni-Freddari, C., Pieri, C. Mech. Ageing Dev. (1980) [Pubmed]
  13. Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor. Rodríguez, C., Brayton, K.A., Brownstein, M., Dixon, J.E. J. Biol. Chem. (1989) [Pubmed]
  14. Structural characterization of the rat carboxypeptidase-E gene. Jung, Y.K., Kunczt, C.J., Pearson, R.K., Dixon, J.E., Fricker, L.D. Mol. Endocrinol. (1991) [Pubmed]
  15. Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice. Srinivasan, S., Bunch, D.O., Feng, Y., Rodriguiz, R.M., Li, M., Ravenell, R.L., Luo, G.X., Arimura, A., Fricker, L.D., Eddy, E.M., Wetsel, W.C. Endocrinology (2004) [Pubmed]
  16. Expression of the rat carboxypeptidase-E gene in neuroendocrine and nonneuroendocrine cell lines. Jung, Y.K., Kunczt, C.J., Pearson, R.K., Fricker, L.D., Dixon, J.E. Mol. Endocrinol. (1992) [Pubmed]
  17. Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC], a neuropeptide processing enzyme. Fricker, L.D., Adelman, J.P., Douglass, J., Thompson, R.C., von Strandmann, R.P., Hutton, J. Mol. Endocrinol. (1989) [Pubmed]
  18. Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes. Castaño, L., Russo, E., Zhou, L., Lipes, M.A., Eisenbarth, G.S. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  19. Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. Wetsel, W.C., Liposits, Z., Seidah, N.G., Collins, S. Neuroendocrinology (1995) [Pubmed]
  20. Carboxypeptidase E in rat antropyloric mucosa: distribution in progenitor and mature endocrine cell types. Hougaard, D.M., Larsson, L.I. Histochem. Cell Biol. (2004) [Pubmed]
  21. Enkephalin convertase: localization to specific neuronal pathways. Lynch, D.R., Strittmatter, S.M., Venable, J.C., Snyder, S.H. J. Neurosci. (1986) [Pubmed]
  22. Pituitary-specific transcriptional initiation sites of the rat carboxypeptidase-H gene and the influence of thyroid hormone status. Smith, D.R., Pallen, C.J., Murphy, D., Lim, L. Mol. Endocrinol. (1992) [Pubmed]
  23. Effects of nerve growth factor on the biosynthesis of chromogranin A and B, secretogranin II and carboxypeptidase H in rat PC12 cells. Laslop, A., Tschernitz, C. Neuroscience (1992) [Pubmed]
  24. Processing of prodynorphin in BRL-3A cells, a rat liver-derived cell line: implications for the specificity of neuropeptide-processing enzymes. Petanceska, S., Zikherman, J., Fricker, L.D., Devi, L. Mol. Cell. Endocrinol. (1993) [Pubmed]
  25. Comparison of the regulation of carboxypeptidase E and prolactin in GH4C1 cells, a rat pituitary cell line. Fricker, L.D., Reaves, B.J., Das, B., Dannies, P.S. Neuroendocrinology (1990) [Pubmed]
  26. Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC Hutton, J.C., Davidson, H.W., Peshavaria, M. Biochem. J. (1987) [Pubmed]
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