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Gene Review

Actvty2  -  activity 2

Mus musculus

Synonyms: Act-2
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High impact information on Actvty2

  • Treatment with azathioprine (a single injection of 100-400 mg/kg ip or 5 daily doses of 80 mg/kg lp) and cyclophosphamide (a single injection of 50--200 mg/kg ip or 5 daily doses of 25 mg/kg ip) resulted in a marked dose-dependent inhibition of NK activity 2 days later [1].
  • Two separate helper T cell-derived lymphokines, interleukin 3 and granulocyte-macrophage colony-stimulating activity-2, were found to stimulate a broad and similar range of hemopoietic colonies in in vitro soft agar cultures including granulocyte, macrophage, granulocyte-macrophage, megakaryocyte, and mixed megakaryocyte colonies [2].
  • Leptin (3 mg/kg intraperitoneally) increased alpha2-AMPK activity 2-fold in muscle in chow-fed mice but not in DIO mice [3].
  • Incubation of the progel B-TIMP-1-neutrophil gelatinase-associated lipocalin complex with alpha-chymase increases gel B activity 2- to 5-fold, suggesting that alpha-chymase activates progel B whether it exists as free monomer or as a complex with TIMP-1 [4].
  • TSH or (Bu)2cAMP (dBcAMP) stimulation of FRTL5 cells transfected with the shorter (219 and 351 bp) ferritin-H 5'-flanking region fragments increased promoter activity 2- to 3-fold [5].

Biological context of Actvty2


Anatomical context of Actvty2


Associations of Actvty2 with chemical compounds


Other interactions of Actvty2


  1. Effect of chemotherapeutic agents on natural cell-mediated cytotoxicity in mice. Mantovani, A., Luini, W., Peri, G., Vecchi, A., Spreafico, F. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. The effect of interleukin 3 and GM-CSA-2 on megakaryocyte and myeloid clonal colony formation. Quesenberry, P.J., Ihle, J.N., McGrath, E. Blood (1985) [Pubmed]
  3. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. Martin, T.L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F., Kahn, B.B. J. Biol. Chem. (2006) [Pubmed]
  4. Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase. Frank, B.T., Rossall, J.C., Caughey, G.H., Fang, K.C. J. Immunol. (2001) [Pubmed]
  5. Thyrotropin and adenosine 3',5'-monophosphate stimulate the activity of the ferritin-H promoter. Chazenbalk, G.D., Wadsworth, H.L., Foti, D., Rapoport, B. Mol. Endocrinol. (1990) [Pubmed]
  6. In-vivo gene transfer to the uterine endometrium. Charnock-Jones, D.S., Sharkey, A.M., Jaggers, D.C., Yoo, H.J., Heap, R.B., Smith, S.K. Hum. Reprod. (1997) [Pubmed]
  7. C-terminal Src kinase (CSK) modulates insulin-like growth factor-I signaling through Src in 3T3-L1 differentiation. Sekimoto, H., Boney, C.M. Endocrinology (2003) [Pubmed]
  8. Bidirectional modulation of mouse natural killer cell and macrophage cytotoxic activities by enkephalins. Kowalski, J., Belowski, D., Wielgus, J. Polish journal of pharmacology. (1995) [Pubmed]
  9. Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone. Khan, A., Hong-Lie, C., Landau, B.R. Endocrinology (1995) [Pubmed]
  10. Regulation of rat luteinizing hormone beta gene expression in transgenic mice by steroids and a gonadotropin-releasing hormone antagonist. Fallest, P.C., Trader, G.L., Darrow, J.M., Shupnik, M.A. Biol. Reprod. (1995) [Pubmed]
  11. Inactivation of corticosteroids in intestinal mucosa by 11 beta-hydroxysteroid: NADP oxidoreductase (EC Burton, A.F., Anderson, F.H. Am. J. Gastroenterol. (1983) [Pubmed]
  12. Trypanosoma cruzi: efficacy of the 2-substituted, 5-nitroimidazoles, MK-436 and L634,549, in tissue culture and mice. Murray, P.K., Habbersett, M.C., Meurer, R.D. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  13. Effects of the H3-receptor inverse agonist thioperamide on the psychomotor effects induced by acutely and repeatedly given cocaine in C57BL/6J mice. Brabant, C., Quertemont, E., Tirelli, E. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  14. Characterization of interferon induced in murine macrophage cultures by 10-carboxymethyl-9-acridanone. Brehm, G., Storch, E., Kirchner, H. Nat. Immun. Cell Growth Regul. (1986) [Pubmed]
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