High impact information on Actvty2

• Treatment with azathioprine (a single injection of 100-400 mg/kg ip or 5 daily doses of 80 mg/kg lp) and cyclophosphamide (a single injection of 50--200 mg/kg ip or 5 daily doses of 25 mg/kg ip) resulted in a marked dose-dependent inhibition of NK activity 2 days later [1].
• Two separate helper T cell-derived lymphokines, interleukin 3 and granulocyte-macrophage colony-stimulating activity-2, were found to stimulate a broad and similar range of hemopoietic colonies in in vitro soft agar cultures including granulocyte, macrophage, granulocyte-macrophage, megakaryocyte, and mixed megakaryocyte colonies [2].
• Leptin (3 mg/kg intraperitoneally) increased alpha2-AMPK activity 2-fold in muscle in chow-fed mice but not in DIO mice [3].
• Incubation of the progel B-TIMP-1-neutrophil gelatinase-associated lipocalin complex with alpha-chymase increases gel B activity 2- to 5-fold, suggesting that alpha-chymase activates progel B whether it exists as free monomer or as a complex with TIMP-1 [4].
• TSH or (Bu)2cAMP (dBcAMP) stimulation of FRTL5 cells transfected with the shorter (219 and 351 bp) ferritin-H 5'-flanking region fragments increased promoter activity 2- to 3-fold [5].

Biological context of Actvty2

• We injected DNA-liposome complexes into the uterine lumen of mice on day 2 of pseudopregnancy and detected reporter gene activity 2 days later [6].

Anatomical context of Actvty2

• IGF-I stimulated CSK kinase activity 2-fold in differentiating 3T3-L1 cells [7].
• Administration of ME or LE at doses of 100 or 10 micrograms/mouse caused inhibition of NK cell and macrophage activity 2 h after injection [8].

Associations of Actvty2 with chemical compounds

• Treatment of ob/ob mice with dexamethasone (25 micrograms/daily for 3 days) increased activity 2- to 3-fold [9].
• In males, castration increased pituitary LUC activity 2- to 4-fold, and this suppressed to intact levels by daily injections of 25 micrograms dihydrotestosterone (DHT) [10].
• When tissue homogenates were fortified with coenzymes, excess NADPH lowered dehydrogenase activity 81%; excess NADP increased dehydrogenase activity 2-fold in three cases [11].
• MK-436 showed activity against amastigotes at a level of 25 micrograms/ml and L634,549 a dihydroxy metabolite of MK-436 showed activity 2 micrograms/ml [12].
• All cocaine-treated mice showed similar levels of sensitized activity 2 and 14 days after the intermittent treatments, whether they received thioperamide or not [13].

Other interactions of Actvty2

• The determination of the molecular weight was in the range of 24,000-27,000 dalton for activity 1 and in the range of 32,000-34,000 dalton for activity 2 [14].

References