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Gene Review

Ank3  -  ankyrin 3, epithelial

Mus musculus

Synonyms: 2900054D09Rik, AI314020, ANK-3, Ank-3, AnkG, ...
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Disease relevance of Ank3


High impact information on Ank3

  • We have recently cloned and characterized ankyrin-3 (also called ankyrin(G)), a new ankyrin that is widely distributed, especially in epithelial tissues, muscle, and neuronal axons (Peters, L.L., K.M. John, F.M. Lu, E.M. Eicher, A. Higgins, M. Yialamas, L.C. Turtzo, A.J. Otsuka, and S.E. Lux. 1995. J. Cell Biol. 130: 313-330) [2].
  • Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes [2].
  • Second, the ankyrin-3-positive vesicles contain lysosomal-associated membrane glycoprotein (LAMP-1), a recognized lysosomal marker [2].
  • Also, epitope-tagged mouse macrophage ankyrin-3, transiently expressed in COS cells, associates with intracellular, not plasma, membranes [2].
  • Here we show that in mouse macrophages, ankyrin-3 is expressed exclusively as two small isoforms (120 and 100 kD) that lack the NH2-terminal repeats [2].

Biological context of Ank3

  • The jcpk intercross allowed the orientation of the Ank3 gene relative to the centromere to be determined [1].

Anatomical context of Ank3


Other interactions of Ank3

  • The Ank3 gene maps to mouse Chromosome 10, approximately 36 cM from the centromere, a locus distinct from Ank1 and Ank2 [3].
  • In immunoprecipitates, the alpha1 and alpha2 subunits of the Na,K-ATPase as well as ankyrin 3 associate with beta-spectrin/alpha- fodrin heteromers and with a pool of beta-spectrin at the sarcolemma that does not contain alpha-fodrin [6].

Analytical, diagnostic and therapeutic context of Ank3


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