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Gene Review

ANK3  -  ankyrin 3, node of Ranvier (ankyrin G)

Homo sapiens

Synonyms: ANK-3, ANKYRIN-G, Ankyrin-3, Ankyrin-G, MRT37
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Disease relevance of ANK3


High impact information on ANK3


Biological context of ANK3


Anatomical context of ANK3


Associations of ANK3 with chemical compounds


Physical interactions of ANK3

  • Expression of chimeras between the two isoforms of ankyrin suggests that the membrane-binding domain of ankyrin-G is critical for reducing the Ina-p of Nav1 [13].

Other interactions of ANK3

  • Moreover, analysis of rat 190-kDa ankyrin G/ankyrin B chimeras shows that all three domains of 190-kDa ankyrin-G are required for preservation of the lateral membrane [9].
  • Human 220-kDa ankyrin-B, a closely related ankyrin isoform, is incapable of preserving the lateral membrane following 190-kDa ankyrin-G depletion [9].
  • Ankyrin-G associates with the principal voltage-gated Na channel in the heart, and loss of this interaction due to mutation of Nav1.5 results in Brugada syndrome [14].
  • A number of genes reported to regulate neural differentiation and function (i.e. NRP1, ANK3, and CHAT) were found under these linkage peaks and may influence the levels of neural activity occurring in individuals participating in a spatial working-memory task [15].
  • In this study, we explored whether ankyrin-G has a role in modifying gating properties of the neuronal Nav1.6 channel that is predominantly localized at nodes of Ranvier and initial segments [13].

Analytical, diagnostic and therapeutic context of ANK3


  1. Ankyrins and human disease: what the electrophysiologist should know. Mohler, P.J. J. Cardiovasc. Electrophysiol. (2006) [Pubmed]
  2. Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. Kretschmer, T., Nguyen, D.H., Beuerman, R.W., Happel, L.T., England, J.D., Tiel, R.L., Kline, D.G. J. Neurosurg. (2002) [Pubmed]
  3. Ankyrin G overexpression in Hutchinson-Gilford progeria syndrome fibroblasts identified through biological filtering of expression profiles. Wang, J., Robinson, J.F., O'neil, C.H., Edwards, J.Y., Williams, C.M., Huff, M.W., Pickering, J.G., Hegele, R.A. J. Hum. Genet. (2006) [Pubmed]
  4. Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. Kretschmer, T., Nguyen, D.H., Beuerman, R.W., Tiel, R.L., Kline, D.G. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. (2004) [Pubmed]
  5. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. Komada, M., Soriano, P. J. Cell Biol. (2002) [Pubmed]
  6. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Mohler, P.J., Rivolta, I., Napolitano, C., LeMaillet, G., Lambert, S., Priori, S.G., Bennett, V. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase alpha subunit. Devarajan, P., Scaramuzzino, D.A., Morrow, J.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. Kapfhamer, D., Miller, D.E., Lambert, S., Bennett, V., Glover, T.W., Burmeister, M. Genomics (1995) [Pubmed]
  9. Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G. Kizhatil, K., Bennett, V. J. Biol. Chem. (2004) [Pubmed]
  10. The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation. Ignatiuk, A., Quickfall, J.P., Hawrysh, A.D., Chamberlain, M.D., Anderson, D.H. J. Biol. Chem. (2006) [Pubmed]
  11. The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. Mohler, P.J., Gramolini, A.O., Bennett, V. J. Biol. Chem. (2002) [Pubmed]
  12. The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. Lopez, C., Métral, S., Eladari, D., Drevensek, S., Gane, P., Chambrey, R., Bennett, V., Cartron, J.P., Le Van Kim, C., Colin, Y. J. Biol. Chem. (2005) [Pubmed]
  13. Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. Shirahata, E., Iwasaki, H., Takagi, M., Lin, C., Bennett, V., Okamura, Y., Hayasaka, K. J. Neurophysiol. (2006) [Pubmed]
  14. Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting. Mohler, P.J., Bennett, V. Curr. Opin. Cardiol. (2005) [Pubmed]
  15. Linkage analyses of event-related potential slow wave phenotypes recorded in a working memory task. Hansell, N.K., Medland, S.E., Ferreira, M.A., Geffen, G.M., Zhu, G., Montgomery, G.W., Duffy, D.L., Wright, M.J., Martin, N.G. Behav. Genet. (2006) [Pubmed]
  16. Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. Kretschmer, T., England, J.D., Happel, L.T., Liu, Z.P., Thouron, C.L., Nguyen, D.H., Beuerman, R.W., Kline, D.G. Neurosci. Lett. (2002) [Pubmed]
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