The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GSTO2  -  glutathione S-transferase omega 2

Homo sapiens

Synonyms: GSTO 2-2, GSTO-2, Glutathione S-transferase omega 2-2, Glutathione S-transferase omega-2, Glutathione-dependent dehydroascorbate reductase, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GSTO2


High impact information on GSTO2

  • The functions of GSTO1 and GSTO2 are not well understood, but recent data suggest that GSTO1 maybe involved in the post-translational modification of the inflammatory cytokine interleukin-1beta [4].
  • The strongest GSTO2 expression was in the testis, which also expresses a larger transcript than other tissues [5].
  • Expression of GSTO2 mRNA was seen in a range of tissues, including the liver, kidney, skeletal muscle and prostate [5].
  • Rabbit reticulocyte lysate degradation studies showed that the GSTO1 Tyr32 and the GSTO2 Tyr130, Ile158, and Asp142/Ile158 variant allozymes were degraded more rapidly than were their respective WT allozymes [6].
  • Overexpression of GSTO2 induced apoptosis of L-02 cells detected by Annexin V-PE staining [7].

Biological context of GSTO2


Anatomical context of GSTO2

  • Expression pattern analysis revealed that GSTO2 was ubiquitously expressed at a low level, with a higher expression in pancreas and prostate [7].
  • Subcellular localization analysis of GSTO2-EGFP fusion protein revealed that GSTO2 distributed to cytoplasm of COS-7 cells and both cytoplasm and nucleus of L-02, QGY-7703 and SMMC-7721 cells [7].
  • GSTO2 is expressed predominantly in the testis, although moderate levels of expression are seen in other tissues [8].

Associations of GSTO2 with chemical compounds

  • Glutathione S-transferase, omega-1 (GSTO1) and the adjacent gene GSTO2, located in this linkage region, were then reported to associate with AAO of AD and PD [9].

Other interactions of GSTO2

  • But different from GSTO1-1, GSTO2 exhibits a high catalytic activity with CDNB [7].
  • METHODS: We have genotyped the polymorphisms rs4925 GSTO1 and rs2297235 GSTO2 in 232 patients with HD and 228 controls [1].


  1. Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. Arning, L., Jagiello, P., Wieczorek, S., Saft, C., Andrich, J., Epplen, J.T. BMC Med. Genet. (2004) [Pubmed]
  2. Polymorphism of glutathione S-transferase Omega gene and risk of cancer. Marahatta, S.B., Punyarit, P., Bhudisawasdi, V., Paupairoj, A., Wongkham, S., Petmitr, S. Cancer Lett. (2006) [Pubmed]
  3. Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer. Pongstaporn, W., Rochanawutanon, M., Wilailak, S., Linasamita, V., Weerakiat, S., Petmitr, S. J. Exp. Clin. Cancer Res. (2006) [Pubmed]
  4. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li, Y.J., Oliveira, S.A., Xu, P., Martin, E.R., Stenger, J.E., Scherzer, C.R., Hauser, M.A., Scott, W.K., Small, G.W., Nance, M.A., Watts, R.L., Hubble, J.P., Koller, W.C., Pahwa, R., Stern, M.B., Hiner, B.C., Jankovic, J., Goetz, C.G., Mastaglia, F., Middleton, L.T., Roses, A.D., Saunders, A.M., Schmechel, D.E., Gullans, S.R., Haines, J.L., Gilbert, J.R., Vance, J.M., Pericak-Vance, M.A., Hulette, C., Welsh-Bohmer, K.A. Hum. Mol. Genet. (2003) [Pubmed]
  5. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Whitbread, A.K., Tetlow, N., Eyre, H.J., Sutherland, G.R., Board, P.G. Pharmacogenetics (2003) [Pubmed]
  6. Glutathione S-transferase omega 1 and omega 2 pharmacogenomics. Mukherjee, B., Salavaggione, O.E., Pelleymounter, L.L., Moon, I., Eckloff, B.W., Schaid, D.J., Wieben, E.D., Weinshilboum, R.M. Drug Metab. Dispos. (2006) [Pubmed]
  7. Cloning, expression and characterization of human glutathione S-transferase Omega 2. Wang, L., Xu, J., Ji, C., Gu, S., Lv, Y., Li, S., Xu, Y., Xie, Y., Mao, Y. Int. J. Mol. Med. (2005) [Pubmed]
  8. Characterization of the omega class of glutathione transferases. Whitbread, A.K., Masoumi, A., Tetlow, N., Schmuck, E., Coggan, M., Board, P.G. Meth. Enzymol. (2005) [Pubmed]
  9. Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases. Li, Y.J., Scott, W.K., Zhang, L., Lin, P.I., Oliveira, S.A., Skelly, T., Doraiswamy, M.P., Welsh-Bohmer, K.A., Martin, E.R., Haines, J.L., Pericak-Vance, M.A., Vance, J.M. Neurobiol. Aging (2006) [Pubmed]
WikiGenes - Universities