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Gene Review

CYP2S1  -  cytochrome P450, family 2, subfamily S,...

Homo sapiens

Synonyms: CYPIIS1, Cytochrome P450 2S1, UNQ891/PRO1906
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Disease relevance of CYP2S1


High impact information on CYP2S1


Chemical compound and disease context of CYP2S1

  • Regarding their metabolism of xenobiotics, much remains to be established, but CYP2S1 metabolizes naphthalene and it is likely that these P450s are responsible for metabolic activation of several different kinds of xenobiotic chemicals and contribute to extrahepatic toxicity and carcinogenesis [7].

Biological context of CYP2S1


Anatomical context of CYP2S1

  • Since CYP2S1 is predominantly expressed in human lung and trachea, it is reasonable to speculate that CYP2S1 may play an important role in metabolizing the environmental chemicals to which human respiratory tissues are exposed [2].
  • Subcellular fractionation and immunostaining revealed that CYP2S1 was localized in the endoplasmic reticulum [8].
  • Nor does the antibody cross-react with heterologously expressed human CYP3A4, CYP2S1, or any of the cytochrome P450 enzymes present in the human liver microsomes [10].
  • CYP2S1 was also inducible in a human lung epithelial cell line [11].

Associations of CYP2S1 with chemical compounds


Regulatory relationships of CYP2S1

  • We conclude that CYP2S1 represents a novel abundantly expressed human P450 with potential importance for extrahepatic xenobiotic metabolism [8].

Other interactions of CYP2S1


Analytical, diagnostic and therapeutic context of CYP2S1

  • Western blot analysis, using an antiserum directed against the C-terminus of the enzyme, detected a protein in human lung with the same mobility as recombinant CYP2S1 [8].
  • INTERPRETATION: These findings increase our understanding of the interaction between therapeutic agents and the skin and suggest a functional role for CYP2S1 in the metabolism of topical drugs and in mediating the response to photochemotherapy in psoriasis [3].
  • In this study, we used mRNA in situ hybridization and immunohistochemistry to investigate the cellular localization of CYP2S1 in various human tissues using tissue microarrays [13].


  1. Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers. Downie, D., McFadyen, M.C., Rooney, P.H., Cruickshank, M.E., Parkin, D.E., Miller, I.D., Telfer, C., Melvin, W.T., Murray, G.I. Clin. Cancer Res. (2005) [Pubmed]
  2. Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine. Wang, S.L., He, X.Y., Hong, J.Y. Drug Metab. Dispos. (2005) [Pubmed]
  3. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Smith, G., Wolf, C.R., Deeni, Y.Y., Dawe, R.S., Evans, A.T., Comrie, M.M., Ferguson, J., Ibbotson, S.H. Lancet (2003) [Pubmed]
  4. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Wu, Z.L., Sohl, C.D., Shimada, T., Guengerich, F.P. Mol. Pharmacol. (2006) [Pubmed]
  5. Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis. Kumarakulasingham, M., Rooney, P.H., Dundas, S.R., Telfer, C., Melvin, W.T., Curran, S., Murray, G.I. Clin. Cancer Res. (2005) [Pubmed]
  6. Identification of specific cellular genes up-regulated late in adenovirus type 12 infection. Dorn, A., Zhao, H., Granberg, F., Hösel, M., Webb, D., Svensson, C., Pettersson, U., Doerfler, W. J. Virol. (2005) [Pubmed]
  7. Novel extrahepatic cytochrome P450s. Karlgren, M., Miura, S., Ingelman-Sundberg, M. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  8. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Rylander, T., Neve, E.P., Ingelman-Sundberg, M., Oscarson, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  9. Identification of genetic polymorphisms of CYP2S1 in a Finnish Caucasian population. Saarikoski, S.T., Suitiala, T., Holmila, R., Impivaara, O., Järvisalo, J., Hirvonen, A., Husgafvel-Pursiainen, K. Mutat. Res. (2004) [Pubmed]
  10. CYP2A13 in Human Respiratory Tissues and Lung Cancers: An Immunohistochemical Study with A New Peptide-Specific Antibody. Zhu, L.R., Thomas, P.E., Lu, G., Reuhl, K.R., Yang, G.Y., Wang, L.D., Wang, S.L., Yang, C.S., He, X.Y., Hong, J.Y. Drug Metab. Dispos. (2006) [Pubmed]
  11. Identification of a novel dioxin-inducible cytochrome P450. Rivera, S.P., Saarikoski, S.T., Hankinson, O. Mol. Pharmacol. (2002) [Pubmed]
  12. CYP2S1: A short review. Saarikoski, S.T., Rivera, S.P., Hankinson, O., Husgafvel-Pursiainen, K. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  13. Localization of cytochrome P450 CYP2S1 expression in human tissues by in situ hybridization and immunohistochemistry. Saarikoski, S.T., Wikman, H.A., Smith, G., Wolff, C.H., Husgafvel-Pursiainen, K. J. Histochem. Cytochem. (2005) [Pubmed]
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