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Gene Review

CYP27A1  -  cytochrome P450, family 27, subfamily A,...

Homo sapiens

Synonyms: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase, CP27, CTX, CYP27, Cytochrome P-450C27/25, ...
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Disease relevance of CYP27A1


Psychiatry related information on CYP27A1


High impact information on CYP27A1


Chemical compound and disease context of CYP27A1


Biological context of CYP27A1


Anatomical context of CYP27A1


Associations of CYP27A1 with chemical compounds


Regulatory relationships of CYP27A1


Other interactions of CYP27A1

  • There was a 60-fold variation in the levels of CYP7A1 mRNA but only a 5-fold variation in the levels of CYP27A1 mRNA [17].
  • Expression of CYP27A1 in CHOP cells did not affect ABCA1 expression and abundance of ABCA1 protein [25].
  • Rifampicin induced CYP27A1 gene transcription, increased intracellular 27-HOC levels, and induced ABCA1 and ABCG1 mRNA expression only in intestine cells [19].
  • The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3beta-hydroxy-Delta(5)-C(27)-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages [26].
  • In addition, dermal fibroblasts contain mRNA of the vitamin D(3)-25-hydroxylases (CYP2R1 and CYP27A1) [27].

Analytical, diagnostic and therapeutic context of CYP27A1


  1. On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. Norlin, M., von Bahr, S., Bjorkhem, I., Wikvall, K. J. Lipid Res. (2003) [Pubmed]
  2. Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES. Uchida, E., Kagawa, N., Sakaki, T., Urushino, N., Sawada, N., Kamakura, M., Ohta, M., Kato, S., Inouye, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Cholecalciferol (vitamin D3) inhibits growth and invasion by up-regulating nuclear receptors and 25-hydroxylase (CYP27A1) in human prostate cancer cells. Tokar, E.J., Webber, M.M. Clin. Exp. Metastasis (2005) [Pubmed]
  4. Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1. Araya, Z., Tang, W., Wikvall, K. Biochem. J. (2003) [Pubmed]
  5. Metabolism of vitamin D(3) by human CYP27A1. Sawada, N., Sakaki, T., Ohta, M., Inouye, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27). Sugama, S., Kimura, A., Chen, W., Kubota, S., Seyama, Y., Taira, N., Eto, Y. J. Inherit. Metab. Dis. (2001) [Pubmed]
  7. Physical activity patterns and exercise performance in cardiac transplant recipients. Myers, J., Gullestad, L., Bellin, D., Ross, H., Vagelos, R., Fowler, M. Journal of cardiopulmonary rehabilitation. (2003) [Pubmed]
  8. Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Motola, D.L., Cummins, C.L., Rottiers, V., Sharma, K.K., Li, T., Li, Y., Suino-Powell, K., Xu, H.E., Auchus, R.J., Antebi, A., Mangelsdorf, D.J. Cell (2006) [Pubmed]
  9. Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews or Moroccan origin. Leitersdorf, E., Reshef, A., Meiner, V., Levitzki, R., Schwartz, S.P., Dann, E.J., Berkman, N., Cali, J.J., Klapholz, L., Berginer, V.M. J. Clin. Invest. (1993) [Pubmed]
  10. Transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal bacteria. Fedorowski, T., Salen, G., Tint, G.S., Mosbach, E. Gastroenterology (1979) [Pubmed]
  11. Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Lin, W., Fullner, K.J., Clayton, R., Sexton, J.A., Rogers, M.B., Calia, K.E., Calderwood, S.B., Fraser, C., Mekalanos, J.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  12. Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. Honda, A., Salen, G., Matsuzaki, Y., Batta, A.K., Xu, G., Hirayama, T., Tint, G.S., Doy, M., Shefer, S. J. Lipid Res. (2005) [Pubmed]
  13. Could steroids mask the diagnosis of cerebrotendinous xanthomatosis? Siman-Tov, T., Meiner, V., Gadoth, N. J. Neurol. Sci. (2006) [Pubmed]
  14. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Bertolini, F., Paul, S., Mancuso, P., Monestiroli, S., Gobbi, A., Shaked, Y., Kerbel, R.S. Cancer Res. (2003) [Pubmed]
  15. Treatment of children with clear-cell sarcoma of the kidney: a report from the National Wilms' Tumor Study Group. Green, D.M., Breslow, N.E., Beckwith, J.B., Moksness, J., Finklestein, J.Z., D'Angio, G.J. J. Clin. Oncol. (1994) [Pubmed]
  16. Cisplatin, carboplatin, and cyclophosphamide combination chemotherapy in advanced-stage ovarian carcinoma: an Eastern Cooperative Oncology Group pilot study. Grem, J., O'Dwyer, P., Elson, P., Simon, N., Trump, D., Frontiera, M., Falkson, G., Vogl, S. J. Clin. Oncol. (1991) [Pubmed]
  17. Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1. Björkhem, I., Araya, Z., Rudling, M., Angelin, B., Einarsson, C., Wikvall, K. J. Biol. Chem. (2002) [Pubmed]
  18. Wavelength-dependent induction of CYP24A1-mRNA after UVB-triggered calcitriol synthesis in cultured human keratinocytes. B??r, M., Domaschke, D., Meye, A., Lehmann, B., Meurer, M. J. Invest. Dermatol. (2007) [Pubmed]
  19. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. Li, T., Chen, W., Chiang, J.Y. J. Lipid Res. (2007) [Pubmed]
  20. Regulation of sterol 27-hydroxylase in human monocyte-derived macrophages: up-regulation by transforming growth factor beta1. Hansson, M., Wikvall, K., Babiker, A. Biochim. Biophys. Acta (2005) [Pubmed]
  21. Differential expression of cholesterol hydroxylases in Alzheimer's disease. Brown, J., Theisler, C., Silberman, S., Magnuson, D., Gottardi-Littell, N., Lee, J.M., Yager, D., Crowley, J., Sambamurti, K., Rahman, M.M., Reiss, A.B., Eckman, C.B., Wolozin, B. J. Biol. Chem. (2004) [Pubmed]
  22. Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis. Ren, S., Hylemon, P., Marques, D., Hall, E., Redford, K., Gil, G., Pandak, W.M. J. Lipid Res. (2004) [Pubmed]
  23. Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. Lee, J.W., Fuda, H., Javitt, N.B., Strott, C.A., Rodriguez, I.R. Exp. Eye Res. (2006) [Pubmed]
  24. Cholesterol-metabolizing cytochromes P450. Pikuleva, I.A. Drug Metab. Dispos. (2006) [Pubmed]
  25. Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. Escher, G., Krozowski, Z., Croft, K.D., Sviridov, D. J. Biol. Chem. (2003) [Pubmed]
  26. Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences. Norlin, M. J. Lipid Res. (2002) [Pubmed]
  27. Dermal fibroblasts pretreated with a sterol Delta(7)-reductase inhibitor produce 25-hydroxyvitamin D(3) upon UVB irradiation. Vantieghem, K., De Haes, P., Bouillon, R., Segaert, S. J. Photochem. Photobiol. B, Biol. (2006) [Pubmed]
  28. Structure-function analysis of CYP27B1 and CYP27A1. Studies on mutants from patients with vitamin D-dependent rickets type I (VDDR-I) and cerebrotendinous xanthomatosis (CTX). Sawada, N., Sakaki, T., Kitanaka, S., Kato, S., Inouye, K. Eur. J. Biochem. (2001) [Pubmed]
  29. Chemoprevention of prostate cancer by cholecalciferol (vitamin D3): 25-hydroxylase (CYP27A1) in human prostate epithelial cells. Tokar, E.J., Webber, M.M. Clin. Exp. Metastasis (2005) [Pubmed]
  30. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). von Bahr, S., Movin, T., Papadogiannakis, N., Pikuleva, I., Rönnow, P., Diczfalusy, U., Björkhem, I. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  31. Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria. Li, X., Hylemon, P., Pandak, W.M., Ren, S. J. Lipid Res. (2006) [Pubmed]
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