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Gene Review

SLC51B  -  solute carrier family 51, beta subunit

Homo sapiens

Synonyms: OST-beta, OSTB, OSTBETA, OSTbeta, Organic solute transporter subunit beta, ...
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High impact information on OSTbeta


Biological context of OSTbeta

  • In contrast to all other organic anion transporters identified to date, transport activity requires the coexpression of two distinct gene products, a predicted 340-amino acid, seven-transmembrane (TM) domain protein (OSTalpha) and a putative 128-amino acid, single-TM domain ancillary polypeptide (OSTbeta) [3].

Anatomical context of OSTbeta

  • By coordinated control of OSTalpha/OSTbeta expression, bile acids may adjust the rate of their own efflux from enterocytes in response to changes in intracellular bile acid levels [4].
  • Interestingly, OSTalpha and OSTbeta mRNAs were highly expressed and widely distributed in human tissues, with the highest levels occurring in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland [2].

Associations of OSTbeta with chemical compounds


Physical interactions of OSTbeta

  • In conclusion, the genes encoding the human OSTalpha/OSTbeta complex are induced by bile acids and FXR [4].

Other interactions of OSTbeta

  • Although the transport function of OSTalpha/OSTbeta has been characterized, little is known about the regulation of its expression [4].
  • The expression of OATP-A/1A2 and OSTbeta was also found in colon, but this was markedly decreased in neoplastic colon tissue [6].


  1. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Ballatori, N., Christian, W.V., Lee, J.Y., Dawson, P.A., Soroka, C.J., Boyer, J.L., Madejczyk, M.S., Li, N. Hepatology (2005) [Pubmed]
  2. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. Seward, D.J., Koh, A.S., Boyer, J.L., Ballatori, N. J. Biol. Chem. (2003) [Pubmed]
  3. Biology of a novel organic solute and steroid transporter, OSTalpha-OSTbeta. Ballatori, N. Exp. Biol. Med. (Maywood) (2005) [Pubmed]
  4. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Landrier, J.F., Eloranta, J.J., Vavricka, S.R., Kullak-Ublick, G.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  5. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Boyer, J.L., Trauner, M., Mennone, A., Soroka, C.J., Cai, S.Y., Moustafa, T., Zollner, G., Lee, J.Y., Ballatori, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  6. Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps. Ballestero, M.R., Monte, M.J., Briz, O., Jimenez, F., Gonzalez-San Martin, F., Marin, J.J. Biochem. Pharmacol. (2006) [Pubmed]
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