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Gene Review

SLC51A  -  solute carrier family 51, alpha subunit

Homo sapiens

Synonyms: OST-alpha, OSTA, OSTalpha, Organic solute transporter subunit alpha, Solute carrier family 51 subunit alpha
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High impact information on OSTalpha


Anatomical context of OSTalpha

  • At the basolateral domain of ileal enterocytes, bile acids are extruded into portal blood by the heterodimeric organic solute transporter OSTalpha/OSTbeta [3].
  • Interestingly, OSTalpha and OSTbeta mRNAs were highly expressed and widely distributed in human tissues, with the highest levels occurring in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland [2].
  • Glutathione transferases (GSTs) catalyze the committed step in the MAP; GST-mu and GST-pi, but not OST-alpha, were detected in neurons and astrocytes in cerebrum from AD patients and controls [4].

Associations of OSTalpha with chemical compounds


Physical interactions of OSTalpha


Other interactions of OSTalpha


  1. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Ballatori, N., Christian, W.V., Lee, J.Y., Dawson, P.A., Soroka, C.J., Boyer, J.L., Madejczyk, M.S., Li, N. Hepatology (2005) [Pubmed]
  2. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. Seward, D.J., Koh, A.S., Boyer, J.L., Ballatori, N. J. Biol. Chem. (2003) [Pubmed]
  3. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Landrier, J.F., Eloranta, J.J., Vavricka, S.R., Kullak-Ublick, G.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  4. Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum. Sidell, K.R., Montine, K.S., Picklo, M.J., Olsen, S.J., Amarnath, V., Montine, T.J. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  5. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Boyer, J.L., Trauner, M., Mennone, A., Soroka, C.J., Cai, S.Y., Moustafa, T., Zollner, G., Lee, J.Y., Ballatori, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  6. Biology of a novel organic solute and steroid transporter, OSTalpha-OSTbeta. Ballatori, N. Exp. Biol. Med. (Maywood) (2005) [Pubmed]
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