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SPACA3  -  sperm acrosome associated 3

Homo sapiens

Synonyms: 1700025M08Rik, ALLP17, CT54, Cancer/testis antigen 54, LYC3, ...
 
 
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Disease relevance of SPACA3

 

High impact information on SPACA3

 

Anatomical context of SPACA3

  • SLLP1 exhibited a very restricted normal tissue expression, being found only in testis/spermatozoa [1].
  • The processed form of SLLP1, which showed an exon-intron organization similar to human c lysozyme, was the major isoform in the acrosome of ejaculated sperm [2].
 

Analytical, diagnostic and therapeutic context of SPACA3

  • The presence of antibodies against SLLP1 was determined by ELISA analysis [1].
  • Our results, therefore, support SLLP1 as a protein target appropriate for additional in vitro study to define its suitability for immunotherapy [1].
  • By immunohistochemistry, we found that the expression of CD23 in SLL discriminates between SLL and MCL and that the expression of CD23 and CD43 in SLL discriminates between SLL and SLLP [3].

References

  1. The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies. Wang, Z., Zhang, Y., Mandal, A., Zhang, J., Giles, F.J., Herr, J.C., Lim, S.H. Clin. Cancer Res. (2004) [Pubmed]
  2. SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. Mandal, A., Klotz, K.L., Shetty, J., Jayes, F.L., Wolkowicz, M.J., Bolling, L.C., Coonrod, S.A., Black, M.B., Diekman, A.B., Haystead, T.A., Flickinger, C.J., Herr, J.C. Biol. Reprod. (2003) [Pubmed]
  3. Flow cytometric and immunohistochemical analysis of small lymphocytic lymphoma, mantle cell lymphoma, and plasmacytoid small lymphocytic lymphoma. Tworek, J.A., Singleton, T.P., Schnitzer, B., Hsi, E.D., Ross, C.W. Am. J. Clin. Pathol. (1998) [Pubmed]
 
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