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Gene Review

Cd9  -  CD9 antigen

Mus musculus

Synonyms: Tspan29
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High impact information on Cd9

  • The cell-surface molecule Cd9, a member of the transmembrane-4 superfamily, interacts with the integrin family and other membrane proteins. and is postulated to participate in cell migration and adhesion [1].
  • Thus, our results show that Cd9 is important in the gamete fusion process at fertilization [1].
  • Expression of Cd9 enhances membrane fusion between muscle cells and promotes viral infection in some cells [1].
  • In normal animals, Cd9 molecules were expressed on the egg microvilli and became densely concentrated at the sperm attachment site [1].
  • Cd9 is expressed on the plasma membrane of the mouse egg, and an anti-Cd9 monoclonal antibody inhibits sperm-egg surface interactions [1].

Anatomical context of Cd9

  • The association of CD9 antigen to VLA integrins is strengthened by the fact that both CD9 and anti-VLA mAb induce aggregation of the two cell lines and inhibit their migration in Transwell chambers [2].
  • In primary cultures of rat FBC isolated 18 days p.c., the NCA/CD9 antigen was expressed by all premature and mature astrocytes, oligodendrocytes, ependymal cells, and microglial cells, but not by E-N-CAM-expressing neuronal progenitor cells and neurons [3].
  • In this way, transfected cell lines expressing the CD9 antigen, the CD31 antigen (two lines), a unique platelet antigen, an X-linked antigen (R1), and a previously unreported monocyte antigen 11D1 were prepared [4].

Associations of Cd9 with chemical compounds


Other interactions of Cd9


Analytical, diagnostic and therapeutic context of Cd9


  1. The gamete fusion process is defective in eggs of Cd9-deficient mice. Kaji, K., Oda, S., Shikano, T., Ohnuki, T., Uematsu, Y., Sakagami, J., Tada, N., Miyazaki, S., Kudo, A. Nat. Genet. (2000) [Pubmed]
  2. CD9 antigen is an accessory subunit of the VLA integrin complexes. Rubinstein, E., Le Naour, F., Billard, M., Prenant, M., Boucheix, C. Eur. J. Immunol. (1994) [Pubmed]
  3. Characterization of rat NCA/CD9 cell surface antigen and its expression by normal and malignant neural cells. Deissler, H., Blass-Kampmann, S., Kindler-Röhrborn, A., Meyer, H.E., Rajewsky, M.F. J. Neurosci. Res. (1996) [Pubmed]
  4. Transfection of genes for human cell surface antigens identified by monoclonal antibodies. Cole, S.R., Kriek, G.W., Hope, R.M., Ashman, L.K. Immunol. Cell Biol. (1989) [Pubmed]
  5. Molecular cloning of the mouse equivalent of CD9 antigen. Rubinstein, E., Billard, M., Plaisance, S., Prenant, M., Boucheix, C. Thromb. Res. (1993) [Pubmed]
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