High impact information on Cd9

• The cell-surface molecule Cd9, a member of the transmembrane-4 superfamily, interacts with the integrin family and other membrane proteins. and is postulated to participate in cell migration and adhesion [1].
• Thus, our results show that Cd9 is important in the gamete fusion process at fertilization [1].
• Expression of Cd9 enhances membrane fusion between muscle cells and promotes viral infection in some cells [1].
• In normal animals, Cd9 molecules were expressed on the egg microvilli and became densely concentrated at the sperm attachment site [1].
• Cd9 is expressed on the plasma membrane of the mouse egg, and an anti-Cd9 monoclonal antibody inhibits sperm-egg surface interactions [1].

Anatomical context of Cd9

• The association of CD9 antigen to VLA integrins is strengthened by the fact that both CD9 and anti-VLA mAb induce aggregation of the two cell lines and inhibit their migration in Transwell chambers [2].
• In primary cultures of rat FBC isolated 18 days p.c., the NCA/CD9 antigen was expressed by all premature and mature astrocytes, oligodendrocytes, ependymal cells, and microglial cells, but not by E-N-CAM-expressing neuronal progenitor cells and neurons [3].
• In this way, transfected cell lines expressing the CD9 antigen, the CD31 antigen (two lines), a unique platelet antigen, an X-linked antigen (R1), and a previously unreported monocyte antigen 11D1 were prepared [4].

Associations of Cd9 with chemical compounds

• The CD9 antigen is a cell surface glycoprotein of unknown function which belongs to the tetraspans family [2].

Other interactions of Cd9

• In HEL cells, CD9 antigen is only associated with VLA-4 [2].

Analytical, diagnostic and therapeutic context of Cd9

• Molecular cloning of the mouse equivalent of CD9 antigen [5].

References