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Gene Review

Pecam1  -  platelet/endothelial cell adhesion molecule 1

Mus musculus

Synonyms: C85791, Cd31, PECAM-1, Pecam, Pecam-1, ...
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Chemical compound and disease context of Pecam1


Biological context of Pecam1


Anatomical context of Pecam1


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Co-localisations of Pecam1


Regulatory relationships of Pecam1


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Analytical, diagnostic and therapeutic context of Pecam1


  1. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. Tang, Q., Hendricks, R.L. J. Exp. Med. (1996) [Pubmed]
  2. Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. Sheibani, N., Newman, P.J., Frazier, W.A. Mol. Biol. Cell (1997) [Pubmed]
  3. Vascular immunotargeting of glucose oxidase to the endothelial antigens induces distinct forms of oxidant acute lung injury: targeting to thrombomodulin, but not to PECAM-1, causes pulmonary thrombosis and neutrophil transmigration. Christofidou-Solomidou, M., Kennel, S., Scherpereel, A., Wiewrodt, R., Solomides, C.C., Pietra, G.G., Murciano, J.C., Shah, S.A., Ischiropoulos, H., Albelda, S.M., Muzykantov, V.R. Am. J. Pathol. (2002) [Pubmed]
  4. PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells. Zhang, J.J., Kelm, R.J., Biswas, P., Kashgarian, M., Madri, J.A. J. Cell. Physiol. (2007) [Pubmed]
  5. Distinct roles for PECAM-1, ICAM-1, and VCAM-1 in recruitment of neutrophils and eosinophils to the cornea in ocular onchocerciasis (river blindness). Kaifi, J.T., Diaconu, E., Pearlman, E. J. Immunol. (2001) [Pubmed]
  6. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Dhanjal, T.S., Pendaries, C., Ross, E.A., Larson, M.K., Protty, M.B., Buckley, C.D., Watson, S.P. Blood (2007) [Pubmed]
  7. Cellular and molecular characterization of a murine non-union model. Choi, P., Ogilvie, C., Thompson, Z., Miclau, T., Helms, J.A. J. Orthop. Res. (2004) [Pubmed]
  8. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Vaporciyan, A.A., DeLisser, H.M., Yan, H.C., Mendiguren, I.I., Thom, S.R., Jones, M.L., Ward, P.A., Albelda, S.M. Science (1993) [Pubmed]
  9. PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane. Dangerfield, J., Larbi, K.Y., Huang, M.T., Dewar, A., Nourshargh, S. J. Exp. Med. (2002) [Pubmed]
  10. Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation. Wong, M.X., Roberts, D., Bartley, P.A., Jackson, D.E. J. Immunol. (2002) [Pubmed]
  11. Eosinophil tissue recruitment to sites of allergic inflammation in the lung is platelet endothelial cell adhesion molecule independent. Miller, M., Sung, K.L., Muller, W.A., Cho, J.Y., Roman, M., Castaneda, D., Nayar, J., Condon, T., Kim, J., Sriramarao, P., Broide, D.H. J. Immunol. (2001) [Pubmed]
  12. Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Li, S., Tan, Y., Viroonchatapan, E., Pitt, B.R., Huang, L. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  13. Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice. Kashani-Sabet, M., Liu, Y., Fong, S., Desprez, P.Y., Liu, S., Tu, G., Nosrati, M., Handumrongkul, C., Liggitt, D., Thor, A.D., Debs, R.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2. Enciso, J.M., Gratzinger, D., Camenisch, T.D., Canosa, S., Pinter, E., Madri, J.A. J. Cell Biol. (2003) [Pubmed]
  15. Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Lu, T.T., Yan, L.G., Madri, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  16. Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. Allport, J.R., Ding, H., Collins, T., Gerritsen, M.E., Luscinskas, F.W. J. Exp. Med. (1997) [Pubmed]
  17. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa, H., Hammer, R.E., Richardson, J.A., Williams, S.C., Clouthier, D.E., Yanagisawa, M. J. Clin. Invest. (1998) [Pubmed]
  18. Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Takashima, S., Kitakaze, M., Asakura, M., Asanuma, H., Sanada, S., Tashiro, F., Niwa, H., Miyazaki Ji, J., Hirota, S., Kitamura, Y., Kitsukawa, T., Fujisawa, H., Klagsbrun, M., Hori, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  19. Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation. Ilan, N., Cheung, L., Pinter, E., Madri, J.A. J. Biol. Chem. (2000) [Pubmed]
  20. PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation. Biswas, P., Canosa, S., Schoenfeld, D., Schoenfeld, J., Li, P., Cheas, L.C., Zhang, J., Cordova, A., Sumpio, B., Madri, J.A. Am. J. Pathol. (2006) [Pubmed]
  21. Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity. Donahower, B., McCullough, S.S., Kurten, R., Lamps, L.W., Simpson, P., Hinson, J.A., James, L.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  22. Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repair. Féraud, O., Mallet, C., Vilgrain, I. Endocrinology (2003) [Pubmed]
  23. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Humphrey, R.K., Bucay, N., Beattie, G.M., Lopez, A., Messam, C.A., Cirulli, V., Hayek, A. Diabetes (2003) [Pubmed]
  24. Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading. Sakuma-Zenke, M., Sakai, A., Nakayamada, S., Kunugita, N., Tabata, T., Uchida, S., Tanaka, S., Mori, T., Nakai, K., Tanaka, Y., Nakamura, T. J. Bone Miner. Res. (2005) [Pubmed]
  25. PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors. Baumann, C.I., Bailey, A.S., Li, W., Ferkowicz, M.J., Yoder, M.C., Fleming, W.H. Blood (2004) [Pubmed]
  26. Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Wheadon, H., Edmead, C., Welham, M.J. Biochem. J. (2003) [Pubmed]
  27. Identification of a functional NF-kappa B site in the platelet endothelial cell adhesion molecule-1 promoter. Botella, L.M., Puig-Kröger, A., Almendro, N., Sánchez-Elsner, T., Muñoz, E., Corbí, A., Bernabéu, C. J. Immunol. (2000) [Pubmed]
  28. Antibodies against the first Ig-like domain of human platelet endothelial cell adhesion molecule-1 (PECAM-1) that inhibit PECAM-1-dependent homophilic adhesion block in vivo neutrophil recruitment. Nakada, M.T., Amin, K., Christofidou-Solomidou, M., O'Brien, C.D., Sun, J., Gurubhagavatula, I., Heavner, G.A., Taylor, A.H., Paddock, C., Sun, Q.H., Zehnder, J.L., Newman, P.J., Albelda, S.M., DeLisser, H.M. J. Immunol. (2000) [Pubmed]
  29. Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment. Lucerna, M., Zernecke, A., de Nooijer, R., de Jager, S.C., Bot, I., van der Lans, C., Kholova, I., Liehn, E.A., van Berkel, T.J., Yla-Herttuala, S., Weber, C., Biessen, E.A. Blood (2007) [Pubmed]
  30. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. Liao, H.J., Kume, T., McKay, C., Xu, M.J., Ihle, J.N., Carpenter, G. J. Biol. Chem. (2002) [Pubmed]
  31. Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. Udell, C.M., Samayawardhena, L.A., Kawakami, Y., Kawakami, T., Craig, A.W. J. Biol. Chem. (2006) [Pubmed]
  32. Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin. Calvo, A., Yokoyama, Y., Smith, L.E., Ali, I., Shih, S.C., Feldman, A.L., Libutti, S.K., Sundaram, R., Green, J.E. Int. J. Cancer (2002) [Pubmed]
  33. VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Healy, A.M., Morgenthau, L., Zhu, X., Farber, H.W., Cardoso, W.V. Dev. Dyn. (2000) [Pubmed]
  34. Embryonic stem cells expressing both platelet endothelial cell adhesion molecule-1 and stage-specific embryonic antigen-1 differentiate predominantly into epiblast cells in a chimeric embryo. Furusawa, T., Ohkoshi, K., Honda, C., Takahashi, S., Tokunaga, T. Biol. Reprod. (2004) [Pubmed]
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