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Gene Review

T7p24  -  helicase

Enterobacteria phage T7

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Disease relevance of T7p24


High impact information on T7p24


Chemical compound and disease context of T7p24


Biological context of T7p24


Associations of T7p24 with chemical compounds

  • The crystal structure of the hexameric helicase shows Arg-522, located at the subunit interface, positioned to interact with the gamma-phosphate of bound nucleoside 5' triphosphate [8].
  • The 4A' gene, which has a leucine codon replacing the 4B initiation codon, specifies a single 566-amino acid protein that can provide the primase and helicase functions required for normal T7 growth [13].

Regulatory relationships of T7p24

  • The T7 gene 4 protein acts processively as helicase to promote leading strand synthesis and distributively as primase to initiate lagging strand synthesis by T7 DNA polymerase [15].

Analytical, diagnostic and therapeutic context of T7p24


  1. Roles of bacteriophage T7 gene 4 proteins in providing primase and helicase functions in vivo. Mendelman, L.V., Notarnicola, S.M., Richardson, C.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7. Sawaya, M.R., Guo, S., Tabor, S., Richardson, C.C., Ellenberger, T. Cell (1999) [Pubmed]
  3. The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Yin, Y.W., Steitz, T.A. Cell (2004) [Pubmed]
  4. DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase. Crampton, D.J., Mukherjee, S., Richardson, C.C. Mol. Cell (2006) [Pubmed]
  5. Coordinated leading and lagging strand DNA synthesis on a minicircular template. Lee, J., Chastain, P.D., Kusakabe, T., Griffith, J.D., Richardson, C.C. Mol. Cell (1998) [Pubmed]
  6. Single-stranded DNA binding protein and DNA helicase of bacteriophage T7 mediate homologous DNA strand exchange. Kong, D., Richardson, C.C. EMBO J. (1996) [Pubmed]
  7. The DNA-unwinding mechanism of the ring helicase of bacteriophage T7. Jeong, Y.J., Levin, M.K., Patel, S.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling. Crampton, D.J., Guo, S., Johnson, D.E., Richardson, C.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Gene 4 helicase of bacteriophage T7 mediates strand transfer through pyrimidine dimers, mismatches, and nonhomologous regions. Kong, D., Griffith, J.D., Richardson, C.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Leading and lagging strand synthesis at the replication fork of bacteriophage T7. Distinct properties of T7 gene 4 protein as a helicase and primase. Nakai, H., Richardson, C.C. J. Biol. Chem. (1988) [Pubmed]
  11. Cloning and expression of gene 4 of bacteriophage T7 and creation and analysis of T7 mutants lacking the 4A primase/helicase or the 4B helicase. Rosenberg, A.H., Patel, S.S., Johnson, K.A., Studier, F.W. J. Biol. Chem. (1992) [Pubmed]
  12. The nucleotide binding site of the helicase/primase of bacteriophage T7. Interaction of mutant and wild-type proteins. Notarnicola, S.M., Richardson, C.C. J. Biol. Chem. (1993) [Pubmed]
  13. Selection, identification, and genetic analysis of random mutants in the cloned primase/helicase gene of bacteriophage T7. Rosenberg, A.H., Griffin, K., Washington, M.T., Patel, S.S., Studier, F.W. J. Biol. Chem. (1996) [Pubmed]
  14. Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteins. Park, K., Debyser, Z., Tabor, S., Richardson, C.C., Griffith, J.D. J. Biol. Chem. (1998) [Pubmed]
  15. The effect of the T7 and Escherichia coli DNA-binding proteins at the replication fork of bacteriophage T7. Nakai, H., Richardson, C.C. J. Biol. Chem. (1988) [Pubmed]
  16. Oligomeric structure of bacteriophage T7 DNA primase/helicase proteins. Patel, S.S., Hingorani, M.M. J. Biol. Chem. (1993) [Pubmed]
  17. Characterization and crystallization of the helicase domain of bacteriophage T7 gene 4 protein. Bird, L.E., Hâkansson, K., Pan, H., Wigley, D.B. Nucleic Acids Res. (1997) [Pubmed]
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