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Gene Review

SYT2  -  synaptotagmin II

Homo sapiens

Synonyms: MYSPC, Synaptotagmin II, Synaptotagmin-2, SytII
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High impact information on SYT2


Biological context of SYT2


Anatomical context of SYT2


Associations of SYT2 with chemical compounds


Regulatory relationships of SYT2


Other interactions of SYT2


Analytical, diagnostic and therapeutic context of SYT2


  1. Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. Baram, D., Adachi, R., Medalia, O., Tuvim, M., Dickey, B.F., Mekori, Y.A., Sagi-Eisenberg, R. J. Exp. Med. (1999) [Pubmed]
  2. Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum. Kida, Y., Sakaguchi, M., Fukuda, M., Mikoshiba, K., Mihara, K. J. Cell Biol. (2000) [Pubmed]
  3. The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. Lang, J., Fukuda, M., Zhang, H., Mikoshiba, K., Wollheim, C.B. EMBO J. (1997) [Pubmed]
  4. Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. Fukuda, M., Aruga, J., Niinobe, M., Aimoto, S., Mikoshiba, K. J. Biol. Chem. (1994) [Pubmed]
  5. Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils. Lindmark, I.M., Karlsson, A., Serrander, L., Francois, P., Lew, D., Rasmusson, B., Stendahl, O., Nüsse, O. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. Pang, Z.P., Melicoff, E., Padgett, D., Liu, Y., Teich, A.F., Dickey, B.F., Lin, W., Adachi, R., S??dhof, T.C. J. Neurosci. (2006) [Pubmed]
  7. Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Chai, Q., Arndt, J.W., Dong, M., Tepp, W.H., Johnson, E.A., Chapman, E.R., Stevens, R.C. Nature (2006) [Pubmed]
  8. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity. Jin, R., Rummel, A., Binz, T., Brunger, A.T. Nature (2006) [Pubmed]
  9. Sequence of the gene for Clostridium botulinum type B neurotoxin associated with infant botulism, expression of the C-terminal half of heavy chain and its binding activity. Ihara, H., Kohda, T., Morimoto, F., Tsukamoto, K., Karasawa, T., Nakamura, S., Mukamoto, M., Kozaki, S. Biochim. Biophys. Acta (2003) [Pubmed]
  10. Anti-sense RNA inhibits the expression of synaptotagmin II in RBL-2H3 and enhances the exocytosis of lysosomes in RBL-2H3. Zhang, J., Lu, W., Li, Y., Wu, J., Zhang, C. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
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