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Chemical Compound Review

AC1O51G7     (2R,4S,5R,6R)-2- [(2S,3S,4S,5R,6S)-5-[(2R...

Synonyms: Ganglioside GT1, GT1b Ganglioside, GT(1)Ganglioside, Ganglioside, GT1, Polysialoganglioside
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Disease relevance of GT1b Ganglioside

  • A 50% inhibition of neurite outgrowth of N18 neuroblasts induced by the glioma cell proteins was observed at the following approximate concentration: 100 microM (0.2 mg/ml) GD1A ganglioside, 20 microM (0.04 mg/ml) GT1B ganglioside, and 5 mg/ml colominic acid [1].
  • Ganglioside GT1b was found to support BoNT/A activity significantly more effectively than GD1a, which was far more effective than GM1 when added to ganglioside-deficient murine cholinergic Neuro 2a or to human adrenergic SK-N-SH neuroblastoma cells [2].
  • Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof [3].
  • Ganglioside GT1b significantly prevented attachment of keratinocytes to fibronectin and also detached previously adherent keratinocytes in a concentration-dependent manner without cell toxicity [4].
  • This translocation can be entirely reversed without losses in activity by a single intraperitoneal injection into the gravid rat of either a mixture of disialo- and trisialoganglioside [polysialoganglioside (PSG)] or by GM1 (50 mg/kg of body weight) given 3 h before onset of the ischemic episode [5].

Psychiatry related information on GT1b Ganglioside


High impact information on GT1b Ganglioside


Biological context of GT1b Ganglioside


Anatomical context of GT1b Ganglioside


Associations of GT1b Ganglioside with other chemical compounds


Gene context of GT1b Ganglioside


Analytical, diagnostic and therapeutic context of GT1b Ganglioside

  • One O-acetylated polysialoganglioside that seems specific of the earlier embryonic stage and up to 21 alkali-stable components could be recognized by high-resolution two-dimensional TLC procedures and quantified by computer-assisted two-dimensional TLC densitometry [29].
  • In chicken, thin layer chromatography (TLC) immunostaining confirms the presence of the Q 211 antigen in at least 3 different polysialoganglioside fractions [30].


  1. Neurite outgrowth of neuroblastoma cells: dependence on adhesion surface--cell surface interactions. Rauvala, H. J. Cell Biol. (1984) [Pubmed]
  2. Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I. Yowler, B.C., Kensinger, R.D., Schengrund, C.L. J. Biol. Chem. (2002) [Pubmed]
  3. Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof. Schengrund, C.L., DasGupta, B.R., Ringler, N.J. J. Neurochem. (1991) [Pubmed]
  4. Ganglioside GT1b inhibits keratinocyte adhesion and migration on a fibronectin matrix. Paller, A.S., Arnsmeier, S.L., Chen, J.D., Woodley, D.T. J. Invest. Dermatol. (1995) [Pubmed]
  5. Gangliosides prevent ischemia-induced down-regulation of protein kinase C in fetal rat brain. Magal, E., Louis, J.C., Aguilera, J., Yavin, E. J. Neurochem. (1990) [Pubmed]
  6. Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment. Mandal, P.K., Pettegrew, J.W. Neurochem. Res. (2004) [Pubmed]
  7. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. Yamashita, T., Higuchi, H., Tohyama, M. J. Cell Biol. (2002) [Pubmed]
  8. Studies on cell adhesion and recognition. I. Extent and specificity of cell adhesion triggered by carbohydrate-reactive proteins (glycosidases and lectins) and by fibronectin. Rauvala, H., Carter, W.G., Hakomori, S.I. J. Cell Biol. (1981) [Pubmed]
  9. Ganglioside modulation regulates epithelial cell adhesion and spreading via ganglioside-specific effects on signaling. Wang, X.Q., Sun, P., Paller, A.S. J. Biol. Chem. (2002) [Pubmed]
  10. Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis. Wang, X.Q., Sun, P., Paller, A.S. J. Biol. Chem. (2001) [Pubmed]
  11. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition. Vinson, M., Strijbos, P.J., Rowles, A., Facci, L., Moore, S.E., Simmons, D.L., Walsh, F.S. J. Biol. Chem. (2001) [Pubmed]
  12. A membrane receptor for gangliosides is associated with central nervous system myelin. Tiemeyer, M., Swank-Hill, P., Schnaar, R.L. J. Biol. Chem. (1990) [Pubmed]
  13. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Ryu, J.K., Shin, W.H., Kim, J., Joe, E.H., Lee, Y.B., Cho, K.G., Oh, Y.J., Kim, S.U., Jin, B.K. Glia (2002) [Pubmed]
  14. GT1b ganglioside prevents tetanus toxin-induced protein kinase C activation and down-regulation in the neonatal brain in vivo. Aguilera, J., Padrós-Giralt, C., Habig, W.H., Yavin, E. J. Neurochem. (1993) [Pubmed]
  15. Botulinum neurotoxin A changes conformation upon binding to ganglioside GT1b. Yowler, B.C., Schengrund, C.L. Biochemistry (2004) [Pubmed]
  16. T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. Bukowski, J.F., Roncarolo, M.G., Spits, H., Krangel, M.S., Morita, C.T., Brenner, M.B., Band, H. Eur. J. Immunol. (2000) [Pubmed]
  17. Sialic acid residues on astrocytes regulate neuritogenesis by controlling the assembly of laminin matrices. Freire, E., Gomes, F.C., Jotha-Mattos, T., Neto, V.M., Silva Filho, F.C., Coelho-Sampaio, T. J. Cell. Sci. (2004) [Pubmed]
  18. Possible involvement of polysialogangliosides in nerve sprouting and cell contact formation: an ultracytochemical in vitro study. Seybold, V., Rösner, H., Greis, C., Beck, E., Rahmann, H. J. Neurochem. (1989) [Pubmed]
  19. Ruthenium red neurotoxicity and interaction with gangliosides in primary cortical cultures. Velasco, I., Tapia, R. J. Neurosci. Res. (1997) [Pubmed]
  20. Enhancement by ganglioside GT1b of annexin I phosphorylation in bovine mammary gland in the presence of phosphatidylserine and Ca2+. Katoh, N., Miyamoto, T. Lipids (1996) [Pubmed]
  21. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death. Manev, H., Favaron, M., Guidotti, A., Costa, E. Mol. Pharmacol. (1989) [Pubmed]
  22. Glycolipid receptors for attachment of Mycoplasma hyopneumoniae to porcine respiratory ciliated cells. Zhang, Q., Young, T.F., Ross, R.F. Infect. Immun. (1994) [Pubmed]
  23. Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice. Yamamoto, H.A., Mohanan, P.V. Brain Res. (2003) [Pubmed]
  24. Content and composition of the gangliosides of forebrain, brain stem and cerebellum of the rat during normal and restricted growth. Yusuf, H.K., Dickerson, J.W. J. Biochem. (1978) [Pubmed]
  25. Modulation of major histocompatibility complex class I genes by interferon-gamma and ganglioside GT 1b in astrocytes: involvement of protein tyrosine phosphatases. Massa, P.T., Wu, C. J. Neurochem. (1996) [Pubmed]
  26. Analysis of phenotypic and functional changes during ganglioside-induced inhibition of human T cell proliferation. Pique, C., Mahé, Y., Scamps, C., Tétaud, C., Tursz, T., Wiels, J. Mol. Immunol. (1991) [Pubmed]
  27. Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling. Sun, P., Wang, X.Q., Lopatka, K., Bangash, S., Paller, A.S. J. Invest. Dermatol. (2002) [Pubmed]
  28. Integrin alpha 5 beta 1 expression is required for inhibition of keratinocyte migration by ganglioside GT1b. Sung, C.C., O'Toole, E.A., Lannutti, B.J., Hunt, J., O'Gorman, M., Woodley, D.T., Paller, A.S. Exp. Cell Res. (1998) [Pubmed]
  29. Further studies on the changes of chicken brain gangliosides during prenatal and postnatal life. Sonnino, S., Bassi, R., Chigorno, V., Tettamanti, G. J. Neurochem. (1990) [Pubmed]
  30. Developmental expression in embryonic rat and chicken brain of a polysialoganglioside-antigen reacting with the monoclonal antibody Q 211. Rösner, H., Greis, C., Henke-Fahle, S. Brain Res. (1988) [Pubmed]
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