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Gene Review

Col10a1  -  collagen, type X, alpha 1

Mus musculus

Synonyms: Col10, Col10a-1, Collagen alpha-1(X) chain
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Disease relevance of Col10a1


High impact information on Col10a1


Biological context of Col10a1

  • Reporter gene expression was seen exclusively in hypertrophic cartilages in the growth plates of long bones, ribs, vertebrae, sternum and mandibles of 17.5-18.5 dpc embryos, confirming that the 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage [4].
  • These established transgenic lines should facilitate the genetic analysis of regulatory pathways of chondrocyte maturation and Col10a1 gene expression in the future [4].
  • Here we show that this enhancer is highly conserved also in the murine and bovine Col10a1 genes, but not found in the known promoter sequences of chicken Col10a1 [4].
  • In preparation for identifying and characterizing the 5'-regulatory sequences and transcription factors which control mammalian Col10a1 gene expression, we have isolated and sequenced the first exon and 5' flanking promoter regions of bovine Col10a1 [5].
  • In this study, we have analyzed the regulatory elements of the human type X collagen (Col10a1) by reporter gene constructs and transient transfections in chondrogenic and nonchondrogenic cells [6].

Other interactions of Col10a1

  • The Col10a1 specific BAC recombination vector described here will enable the specific analysis of effector gene functions in hypertrophic cartilage during skeletal development, endochondral ossification, and fracture callus healing [1].

Analytical, diagnostic and therapeutic context of Col10a1

  • The identification of the mouse genomic clone as the alpha 1(X) collagen gene (Col10a1) was confirmed by in situ hybridization of a fragment of the mouse genomic clone to sections from newborn mice [7].


  1. BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter. Gebhard, S., Hattori, T., Bauer, E., Bösl, M.R., Schlund, B., Pöschl, E., Adam, N., de Crombrugghe, B., von der Mark, K. Histochem. Cell Biol. (2007) [Pubmed]
  2. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. Zheng, Q., Zhou, G., Morello, R., Chen, Y., Garcia-Rojas, X., Lee, B. J. Cell Biol. (2003) [Pubmed]
  3. Twisted Gastrulation Modulates Bone Morphogenetic Protein-induced Collagen II and X Expression in Chondrocytes in Vitro and in Vivo. Schmidl, M., Adam, N., Surmann-Schmitt, C., Hattori, T., Stock, M., Dietz, U., de Crombrugghe, B., P??schl, E., von der Mark, K. J. Biol. Chem. (2006) [Pubmed]
  4. A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo. Gebhard, S., Pöschl, E., Riemer, S., Bauer, E., Hattori, T., Eberspaecher, H., Zhang, Z., Lefebvre, V., de Crombrugghe, B., von der Mark, K. Matrix Biol. (2004) [Pubmed]
  5. Sequence comparison of three mammalian type-X collagen promoters and preliminary functional analysis of the human promoter. Thomas, J.T., Sweetman, W.A., Cresswell, C.J., Wallis, G.A., Grant, M.E., Boot-Handford, R.P. Gene (1995) [Pubmed]
  6. Localization of silencer and enhancer elements in the human type X collagen gene. Beier, F., Vornehm, S., Pöschl, E., von der Mark, K., Lammi, M.J. J. Cell. Biochem. (1997) [Pubmed]
  7. Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10. Apte, S.S., Seldin, M.F., Hayashi, M., Olsen, B.R. Eur. J. Biochem. (1992) [Pubmed]
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