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Gene Review

Twist2  -  twist basic helix-loop-helix transcription...

Mus musculus

Synonyms: Dermis-expressed protein 1, Dermo-1, Dermo1, Twist-related protein 2, bHLHa39
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Disease relevance of Twist2

  • Mice homozygous for a twist-2 null allele or doubly heterozygous for twist-1 and -2 alleles show elevated expression of proinflammatory cytokines, resulting in perinatal death from cachexia [1].

High impact information on Twist2


Biological context of Twist2


Analytical, diagnostic and therapeutic context of Twist2

  • When the essential Wnt transducer beta-catenin is mutated in En1 cells, it results in the loss of Dermo1-expressing dorsal dermal progenitors and dermis [5].
  • Using the RT-PCR method, the mRNA levels of Dermo-1 and twist were found to be decreased by the treatment with rhBMP-2 in C3H10T1/2 cells [6].
  • We also observed that the mRNA level of Dermo-1 was decreased about fourfold by the treatment with rhBMP-2 in C3H10T1/2 cells by Northern blot analysis [6].


  1. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Sosić, D., Richardson, J.A., Yu, K., Ornitz, D.M., Olson, E.N. Cell (2003) [Pubmed]
  2. Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Tajbakhsh, S., Rocancourt, D., Buckingham, M. Nature (1996) [Pubmed]
  3. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Yu, K., Xu, J., Liu, Z., Sosic, D., Shao, J., Olson, E.N., Towler, D.A., Ornitz, D.M. Development (2003) [Pubmed]
  4. The expression of the homeobox gene Msx1 reveals two populations of dermal progenitor cells originating from the somites. Houzelstein, D., Chéraud, Y., Auda-Boucher, G., Fontaine-Pérus, J., Robert, B. Development (2000) [Pubmed]
  5. Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Atit, R., Sgaier, S.K., Mohamed, O.A., Taketo, M.M., Dufort, D., Joyner, A.L., Niswander, L., Conlon, R.A. Dev. Biol. (2006) [Pubmed]
  6. Identification of DERMO-1 as a member of helix-loop-helix type transcription factors expressed in osteoblastic cells. Tamura, M., Noda, M. J. Cell. Biochem. (1999) [Pubmed]
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