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Gene Review

RAET1E  -  retinoic acid early transcript 1E

Homo sapiens

Synonyms: LETAL, Lymphocyte effector toxicity activation ligand, N2DL-4, N2DL4, NKG2D ligand 4, ...
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Disease relevance of RAET1E


High impact information on RAET1E


Biological context of RAET1E


Anatomical context of RAET1E

  • In addition, Letal induced the killing of cancer cells by CD8(+) and NK cells [7].

Associations of RAET1E with chemical compounds

  • Letal engagement increased the expression of the glucose transporter Glut-1, enhanced glucose up-take, and protected CD8+ lymphocytes from cisplatin-induced killing [1].
  • Unlike other NKG2D ligands, Letal mRNA expression progressively decreased after treatment of tumor cells with retinoic acid [7].
  • The synthetic peptides consisted, respectively, of residues 59-81 of the human surfactant protein SP-B and 21 amino acid residue peptides containing repeating units of arginine separated by either four or eight leucines (RL4 or RL8) [8].

Other interactions of RAET1E


Analytical, diagnostic and therapeutic context of RAET1E

  • We propose that Letal could be used for the ex vivo expansion of apoptosis-resistant tumor-reactive cytotoxic lymphocytes for adoptive transfer [1].
  • Particularly in the biologic therapy of cancer, identifiable antigenic T-cell targets restricted by MHC molecules and the related novel stress molecules such as MICA/B and Letal allow a degree of precision previously unknown in cancer therapy [10].


  1. Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells. Conejo-Garcia, J.R., Benencia, F., Courreges, M.C., Gimotty, P.A., Khang, E., Buckanovich, R.J., Frauwirth, K.A., Zhang, L., Katsaros, D., Thompson, C.B., Levine, B., Coukos, G. Cancer Res. (2004) [Pubmed]
  2. Inflammatory polyradiculoneuropathy with spinal cord involvement and lethal [correction of letal] outcome after hepatitis B vaccination. Sindern, E., Schröder, J.M., Krismann, M., Malin, J.P. J. Neurol. Sci. (2001) [Pubmed]
  3. Molluscicidal and piscicidal activities of Venezuelan Chrysobalanaceae plants. Bilia, A.R., Braca, A., Mendez, J., Morelli, I. Life Sci. (2000) [Pubmed]
  4. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. Bacon, L., Eagle, R.A., Meyer, M., Easom, N., Young, N.T., Trowsdale, J. J. Immunol. (2004) [Pubmed]
  5. Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation. Seiler, M., Brabcova, I., Viklicky, O., Hribova, P., Rosenberger, C., Pratschke, J., Lodererova, A., Matz, M., Schönemann, C., Reinke, P., Volk, H.D., Kotsch, K. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2007) [Pubmed]
  6. Photooxidation of epinephrine sensitized by methylene blue as an assay for the evaluation of alpha-mercaptopropionylglycine as a free radical scavenger. Ortolani, O., Conti, A., Imperatore, R., Sommella, P., Cuocolo, R. Boll. Soc. Ital. Biol. Sper. (1982) [Pubmed]
  7. Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Conejo-Garcia, J.R., Benencia, F., Courreges, M.C., Khang, E., Zhang, L., Mohamed-Hadley, A., Vinocur, J.M., Buckanovich, R.J., Thompson, C.B., Levine, B., Coukos, G. Cancer Biol. Ther. (2003) [Pubmed]
  8. Raman spectroscopic studies of model human pulmonary surfactant systems: phospholipid interactions with peptide paradigms for the surfactant protein SP-B. Vincent, J.S., Revak, S.D., Cochrane, C.G., Levin, I.W. Biochemistry (1991) [Pubmed]
  9. ULBP4 is a novel ligand for human NKG2D. Jan Chalupny, N., Sutherland, C.L., Lawrence, W.A., Rein-Weston, A., Cosman, D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. Lotze, M.T., Wang, E., Marincola, F.M., Hanna, N., Bugelski, P.J., Burns, C.A., Coukos, G., Damle, N., Godfrey, T.E., Howell, W.M., Panelli, M.C., Perricone, M.A., Petricoin, E.F., Sauter, G., Scheibenbogen, C., Shivers, S.C., Taylor, D.L., Weinstein, J.N., Whiteside, T.L. J. Immunother. (2005) [Pubmed]
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