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Gene Review

CKS1BP7  -  CDC28 protein kinase regulatory subunit 1B...

Homo sapiens

Synonyms: CKS1, CKS1A
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High impact information on CKS1A


Biological context of CKS1A

  • Overexpression of Skp2 and Cks1 was observed in aggressive CRC and is responsible for down-regulation of p27 levels [6].
  • We show that complex formation between Cks1 and Skp2 causes conformational changes in both proteins in regions distant from the respective binding sites [7].
  • Also, whilst Cks1 binds to the most C-terminal LRRs of the elongated Skp2 molecule, the interaction induces conformational changes at the distant N-terminal LRRs, close to the F-box motif [7].
  • Here, we demonstrate that protein levels of Skp2 and its accessory protein, Cks1 increased as density-arrested preadipocytes re-entered the cell cycle during clonal expansion, decreased with differentiation-induced growth arrest, and became refractory to hormonal stimulation following the onset of terminal adipocyte differentiation [8].
  • The results support the hypothesis that induction of mitosis by GA is brought about by increased p34cdc2/CDC28 protein kinase activity, which may be the result of transcriptional activation of the cdc2Os-2, cycOs1 and cycOs2 genes [9].

Anatomical context of CKS1A

  • In contrast, the substrate recognition components Skp2 and Cks1 are almost undetectable in resting T cells and are transcriptionally induced upon costimulation [10].

Associations of CKS1A with chemical compounds

  • Activation of Ubiquitin Ligase SCF(Skp2) by Cks1: Insights from Hydrogen Exchange Mass Spectrometry [7].

Regulatory relationships of CKS1A


  1. A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Ghiara, J.B., Richardson, H.E., Sugimoto, K., Henze, M., Lew, D.J., Wittenberg, C., Reed, S.I. Cell (1991) [Pubmed]
  2. Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55. Boronat, S., Campbell, J.L. Mol. Cell. Biol. (2007) [Pubmed]
  3. Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Shulewitz, M.J., Inouye, C.J., Thorner, J. Mol. Cell. Biol. (1999) [Pubmed]
  4. Conservation of function and regulation within the Cdc28/cdc2 protein kinase family: characterization of the human Cdc2Hs protein kinase in Saccharomyces cerevisiae. Wittenberg, C., Reed, S.I. Mol. Cell. Biol. (1989) [Pubmed]
  5. Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray. Han, H., Bearss, D.J., Browne, L.W., Calaluce, R., Nagle, R.B., Von Hoff, D.D. Cancer Res. (2002) [Pubmed]
  6. Prognostic role of p27Kip1 deregulation in colorectal cancer. Hershko, D.D., Shapira, M. Cancer (2006) [Pubmed]
  7. Activation of Ubiquitin Ligase SCF(Skp2) by Cks1: Insights from Hydrogen Exchange Mass Spectrometry. Yao, Z.P., Zhou, M., Kelly, S.E., Seeliger, M.A., Robinson, C.V., Itzhaki, L.S. J. Mol. Biol. (2006) [Pubmed]
  8. Hormonal induction of adipogenesis induces Skp2 expression through PI3K and MAPK pathways. Auld, C.A., Caccia, C.D., Morrison, R.F. J. Cell. Biochem. (2007) [Pubmed]
  9. Gibberellin promotes histone H1 kinase activity and the expression of cdc2 and cyclin genes during the induction of rapid growth in deepwater rice internodes. Sauter, M., Mekhedov, S.L., Kende, H. Plant J. (1995) [Pubmed]
  10. CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation. Appleman, L.J., Chernova, I., Li, L., Boussiotis, V.A. Cell Cycle (2006) [Pubmed]
  11. G1 control in yeast and animal cells. Reed, S.I., Dulic, V., Lew, D.J., Richardson, H.E., Wittenberg, C. Ciba Found. Symp. (1992) [Pubmed]
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