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Gene Review

Epha5  -  Eph receptor A5

Mus musculus

Synonyms: AI854630, AW125296, Brain-specific kinase, Bsk, CEK-7, ...
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High impact information on Epha5

  • Complementary to the expression of Elf-1, an eph family receptor, Bsk, is expressed in the hippocampus in a lateral to medial gradient, consistent with a function as a receptor for Elf-1 [1].
  • Further, Elf-1 specifically bound Bsk, eliciting tyrosine kinase activity [1].
  • We have shown that at the time of target innervation, Bsk, an eph family receptor, is expressed at high levels in several brain regions including the hippocampus, olfactory bulb, and retina [2].
  • In situ hybridization analysis of adult mouse brain sections indicates that bsk is expressed at high levels in the hippocampus, tenia tecta, indusium griseum, and the piriform cortex, major components of the limbic system that are important for learning and memory [3].
  • Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system [3].

Biological context of Epha5

  • Transgene integration in the GNR23 mouse line resulted in a 26 kb deletion in chromosome 5, approximately 67 kb 3' to Epha5 [4].
  • We report here that Bsk expression exhibits dynamic changes during embryogenesis [5].

Anatomical context of Epha5


Associations of Epha5 with chemical compounds


  1. Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system. Gao, P.P., Zhang, J.H., Yokoyama, M., Racey, B., Dreyfus, C.F., Black, I.B., Zhou, R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: potential roles in neuron-target interaction. Zhang, J.H., Cerretti, D.P., Yu, T., Flanagan, J.G., Zhou, R. J. Neurosci. (1996) [Pubmed]
  3. Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system. Zhou, R., Copeland, T.D., Kromer, L.F., Schulz, N.T. J. Neurosci. Res. (1994) [Pubmed]
  4. Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons. Gamble, J.A., Karunadasa, D.K., Pape, J.R., Skynner, M.J., Todman, M.G., Bicknell, R.J., Allen, J.P., Herbison, A.E. J. Neurosci. (2005) [Pubmed]
  5. Dynamic expression suggests multiple roles of the eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis. Zhang, J.H., Pimenta, A.F., Levitt, P., Zhou, R. Brain Res. Mol. Brain Res. (1997) [Pubmed]
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