High impact information on Epha5

• Complementary to the expression of Elf-1, an eph family receptor, Bsk, is expressed in the hippocampus in a lateral to medial gradient, consistent with a function as a receptor for Elf-1 [1].
• Further, Elf-1 specifically bound Bsk, eliciting tyrosine kinase activity [1].
• We have shown that at the time of target innervation, Bsk, an eph family receptor, is expressed at high levels in several brain regions including the hippocampus, olfactory bulb, and retina [2].
• In situ hybridization analysis of adult mouse brain sections indicates that bsk is expressed at high levels in the hippocampus, tenia tecta, indusium griseum, and the piriform cortex, major components of the limbic system that are important for learning and memory [3].
• Isolation and characterization of Bsk, a growth factor receptor-like tyrosine kinase associated with the limbic system [3].

Biological context of Epha5

• Transgene integration in the GNR23 mouse line resulted in a 26 kb deletion in chromosome 5, approximately 67 kb 3' to Epha5 [4].
• We report here that Bsk expression exhibits dynamic changes during embryogenesis [5].

Anatomical context of Epha5

• Our analysis shows that bsk is a growth factor receptor-like protein tyrosine kinase and that its greatest expression in the adult brain is associated with components of the limbic system [3].
• In 16.5 day mouse embryos, bsk is expressed predominantly in the primordial cortex of the telencephalon [3].
• The topography of Bsk expression is in the form of gradients in several regions of the brain, including the lateral septum, spinal cord, as well as the hippocampus [5].
• Bsk expression in the midbrain, hindbrain and spinal cord, however, gradually decreases while in the forebrain increases over time [5].
• In early embryos, Bsk is widely transcribed in the nervous system, including the forebrain, midbrain, hindbrain and spinal cord [5].

Associations of Epha5 with chemical compounds

• We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase) [3].

References