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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Paramyxoviridae


High impact information on Paramyxoviridae

  • Until this study, the disulfide linkages of this HN and structurally similar attachment proteins of other members of the paramyxoviridae family were undefined [6].
  • This is the first report of the recovery of an infectious HRSV lacking a fusion protein of the Paramyxoviridae family and of manipulation of the HRSV entry pathway via incorporation of a nonparamyxoviral transmembrane glycoprotein [7].
  • Probable human infection with a newly described virus in the family Paramyxoviridae. The NSW Expert Group [8].
  • In this review, we summarize the main experimental data pointing out the abundance of structural disorder within measles virus N and P. We also describe studies indicating that structural disorder is a widespread property in the replicative complex of Paramyxoviridae and, more generally, of Mononegavirales [9].
  • Significant differences in nucleocapsid morphology within the Paramyxoviridae [10].

Chemical compound and disease context of Paramyxoviridae


Biological context of Paramyxoviridae


Gene context of Paramyxoviridae

  • CONCLUSIONS: The morphologic characteristics of the virions and the distribution patterns of the HN and NP proteins in PK-15 infected cells indicate that the mechanisms of LPMV replication are generally similar to those of the members of the Paramyxoviridae family [20].
  • The M protein appears to be the most highly conserved among the Paramyxoviridae proteins [21].
  • Comparisons within all the genera of the Paramyxoviridae (Pneumovirus, Morbillivirus, Paramyxovirus and Rubullavirus) show that low amino acid identity between F protein transmembrane domains is a feature of different species of virus rather than of strain differences [22].
  • Among them, human MxA is known to interfere with the replication of measles, human, and bovine parainfluenza-3 viruses (BoPi3V), that is, three members of the Paramyxoviridae family [23].
  • As replication in bovine cells of Pi3, respiratory syncytial (RS), and Sendai (Se) viruses, all members of the same family, is known to be reduced on IFN-alpha incorporation into the culture medium, it was hypothesized that the BoMx1 pathway possibly was involved, its antiviral spectrum thus probably extending to Paramyxoviridae [23].


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  2. Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin. Langedijk, J.P., Daus, F.J., van Oirschot, J.T. J. Virol. (1997) [Pubmed]
  3. Role of a highly conserved NH(2)-terminal domain of the human parainfluenza virus type 3 RNA polymerase. Malur, A.G., Choudhary, S.K., De, B.P., Banerjee, A.K. J. Virol. (2002) [Pubmed]
  4. Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. Ulane, C.M., Kentsis, A., Cruz, C.D., Parisien, J.P., Schneider, K.L., Horvath, C.M. J. Virol. (2005) [Pubmed]
  5. Identification and phylogenetic comparison of Salem virus, a novel paramyxovirus of horses. Renshaw, R.W., Glaser, A.L., Van Campen, H., Weiland, F., Dubovi, E.J. Virology (2000) [Pubmed]
  6. Determination of the disulfide bond arrangement of Newcastle disease virus hemagglutinin neuraminidase. Correlation with a beta-sheet propeller structural fold predicted for paramyxoviridae attachment proteins. Pitt, J.J., Da Silva, E., Gorman, J.J. J. Biol. Chem. (2000) [Pubmed]
  7. Infectivity of a human respiratory syncytial virus lacking the SH, G, and F proteins is efficiently mediated by the vesicular stomatitis virus G protein. Oomens, A.G., Megaw, A.G., Wertz, G.W. J. Virol. (2003) [Pubmed]
  8. Probable human infection with a newly described virus in the family Paramyxoviridae. The NSW Expert Group. Chant, K., Chan, R., Smith, M., Dwyer, D.E., Kirkland, P. Emerging Infect. Dis. (1998) [Pubmed]
  9. Structural disorder within the replicative complex of measles virus: functional implications. Bourhis, J.M., Canard, B., Longhi, S. Virology (2006) [Pubmed]
  10. Significant differences in nucleocapsid morphology within the Paramyxoviridae. Bhella, D., Ralph, A., Murphy, L.B., Yeo, R.P. J. Gen. Virol. (2002) [Pubmed]
  11. The 36K polypeptide synthesized in Newcastle disease virus-infected cells possesses properties predicted for the hypothesized 'V' protein. Samson, A.C., Levesley, I., Russell, P.H. J. Gen. Virol. (1991) [Pubmed]
  12. Morphogenesis and structure of caprine respiratory syncytial virus. Lehmkuhl, H.D., Smith, M.H., Cutlip, R.C. Arch. Virol. (1980) [Pubmed]
  13. Prior infection by respiratory syncytial virus or parainfluenza viruses augments virus-specific IgG responses induced by the measles/mumps/rubella vaccine. Ziola, B., Karvonen, B., Stewart, J. Viral Immunol. (1994) [Pubmed]
  14. Pneumovirus-like characteristics of the mRNA and proteins of turkey rhinotracheitis virus. Cavanagh, D., Barrett, T. Virus Res. (1988) [Pubmed]
  15. Antiviral activity of cholesteryl esters of cinnamic acid derivatives. Galabov, A.S., Nikolaeva, L., Todorova, D., Milkova, T. Z. Naturforsch., C, J. Biosci. (1998) [Pubmed]
  16. Sequence characterization and expression of the matrix protein gene of human parainfluenza virus type 1. Power, U.F., Ryan, K.W., Portner, A. Virology (1992) [Pubmed]
  17. Conserved structures among the nucleocapsid proteins of the paramyxoviridae: complete nucleotide sequence of human parainfluenza virus type 3 NP mRNA. Sánchez, A., Banerjee, A.K., Furuichi, Y., Richardson, M.A. Virology (1986) [Pubmed]
  18. The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion. Chen, L., Gorman, J.J., McKimm-Breschkin, J., Lawrence, L.J., Tulloch, P.A., Smith, B.J., Colman, P.M., Lawrence, M.C. Structure (Camb.) (2001) [Pubmed]
  19. Completion of the full-length genome sequence of Menangle virus: characterisation of the polymerase gene and genomic 5' trailer region. Bowden, T.R., Boyle, D.B. Arch. Virol. (2005) [Pubmed]
  20. Uptake of porcine rubulavirus (LPMV) by PK-15 cells. Hernández-Jáuregui, P., Yacoub, A., Kennedy, S., Curran, B., Téllez, C., Svenda, M., Ljung, L., Moreno-López, J. Arch. Med. Res. (2001) [Pubmed]
  21. Molecular cloning and sequence analysis of the human parainfluenza 3 virus gene encoding the matrix protein. Galinski, M.S., Mink, M.A., Lambert, D.M., Wechsler, S.L., Pons, M.W. Virology (1987) [Pubmed]
  22. The ectodomains but not the transmembrane domains of the fusion proteins of subtypes A and B avian pneumovirus are conserved to a similar extent as those of human respiratory syncytial virus. Naylor, C.J., Britton, P., Cavanagh, D. J. Gen. Virol. (1998) [Pubmed]
  23. Resistance of paramyxoviridae to type I interferon-induced Bos taurus Mx1 dynamin. Leroy, M., Baise, E., Pire, G., Gérardin, J., Desmecht, D. J. Interferon Cytokine Res. (2005) [Pubmed]
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