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Gene Review

Hic1  -  hypermethylated in cancer 1

Mus musculus

Synonyms: AA408311, HIC-1, Hic-1, Hypermethylated in cancer 1 protein
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Disease relevance of Hic1


High impact information on Hic1

  • Homozygous disruption of Hic1 impairs development and results in embryonic and perinatal lethality in mice [1].
  • The complete loss of Hic1 function in the heterozygous mice seems to involve dense methylation of the promoter of the remaining wild-type allele [1].
  • HIC1 encodes a zinc-finger transcription factor that acts as a transcriptional repressor [3].
  • Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome [4].
  • Comparison of genomic and cDNA sequences predicts two exons for the murine Hic1 [2].

Biological context of Hic1

  • During fetal development, Hic1 additionally is expressed in mesenchymes apposed to precartilaginous condensations, at many interfaces to budding epithelia of inner organs, and weakly in muscles [2].
  • During embryonic development, Hic1 is expressed in mesenchymes of the sclerotomes, lateral body wall, limb and cranio-facial regions embedding the outgrowing peripheral nerves during their differentiation [2].


  1. Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Chen, W.Y., Zeng, X., Carter, M.G., Morrell, C.N., Chiu Yen, R.W., Esteller, M., Watkins, D.N., Herman, J.G., Mankowski, J.L., Baylin, S.B. Nat. Genet. (2003) [Pubmed]
  2. Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Grimm, C., Spörle, R., Schmid, T.E., Adler, I.D., Adamski, J., Schughart, K., Graw, J. Hum. Mol. Genet. (1999) [Pubmed]
  3. HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. Valenta, T., Lukas, J., Doubravska, L., Fafilek, B., Korinek, V. EMBO J. (2006) [Pubmed]
  4. Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Carter, M.G., Johns, M.A., Zeng, X., Zhou, L., Zink, M.C., Mankowski, J.L., Donovan, D.M., Baylin, S.B. Hum. Mol. Genet. (2000) [Pubmed]
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