Gene Review:
HIC1 - hypermethylated in cancer 1
Homo sapiens
Synonyms:
Hic-1, Hypermethylated in cancer 1 protein, ZBTB29, ZNF901, Zinc finger and BTB domain-containing protein 29, ...
Waha,
Wang,
Golanska,
Olesen,
Reuter,
Fukayama,
Sugano,
Fujita,
Ushiama,
Liberski,
Szybka,
Maekawa,
Pietsch,
Guldberg,
Rieske,
Sörensen,
Murty,
Koul,
Aggerholm,
Zhang,
Koch,
Narayan,
Wozniak,
Schramm,
Piston,
Witusik,
Hokland,
Zakrzewska,
Kulczycka-Wojdala,
Kashiwabara,
Assaad,
McKiernan,
Goodman,
Papierz,
Zakrzewski,
Leprince,
Mansukhani,
Dobrzynski,
Piaskowski,
Hartmann,
Wiestler,
Chaganti,
Mack,
Holm,
Zawlik,
Rocheleau,
Kakizoe,
Nomoto,
Bacik,
Bosl,
Waha,
Fleuriel,
Houldsworth,
Berthold,
- Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Lindsey, J.C., Lusher, M.E., Anderton, J.A., Bailey, S., Gilbertson, R.J., Pearson, A.D., Ellison, D.W., Clifford, S.C. Carcinogenesis (2004)
- Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer. Maekawa, M., Sugano, K., Ushiama, M., Fukayama, N., Nomoto, K., Kashiwabara, H., Fujita, S., Kakizoe, T. Clin. Chem. Lab. Med. (2001)
- Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Chen, W., Cooper, T.K., Zahnow, C.A., Overholtzer, M., Zhao, Z., Ladanyi, M., Karp, J.E., Gokgoz, N., Wunder, J.S., Andrulis, I.L., Levine, A.J., Mankowski, J.L., Baylin, S.B. Cancer Cell (2004)
- Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms. Rathi, A., Virmani, A.K., Harada, K., Timmons, C.F., Miyajima, K., Hay, R.J., Mastrangelo, D., Maitra, A., Tomlinson, G.E., Gazdar, A.F. Clin. Cancer Res. (2003)
- DNA methylation changes in hematologic malignancies: biologic and clinical implications. Issa, J.P., Baylin, S.B., Herman, J.G. Leukemia (1997)
- Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Chen, W.Y., Wang, D.H., Yen, R.C., Luo, J., Gu, W., Baylin, S.B. Cell (2005)
- Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Chen, W.Y., Zeng, X., Carter, M.G., Morrell, C.N., Chiu Yen, R.W., Esteller, M., Watkins, D.N., Herman, J.G., Mankowski, J.L., Baylin, S.B. Nat. Genet. (2003)
- Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer. Nicoll, G., Crichton, D.N., McDowell, H.E., Kernohan, N., Hupp, T.R., Thompson, A.M. Br. J. Cancer (2001)
- Analysis of HIC-1 methylation and transcription in human ependymomas. Waha, A., Koch, A., Hartmann, W., Mack, H., Schramm, J., Sörensen, N., Berthold, F., Wiestler, O.D., Pietsch, T., Waha, A. Int. J. Cancer (2004)
- The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Deltour, S., Pinte, S., Guerardel, C., Wasylyk, B., Leprince, D. Mol. Cell. Biol. (2002)
- HIC1 hypermethylation is a late event in hematopoietic neoplasms. Issa, J.P., Zehnbauer, B.A., Kaufmann, S.H., Biel, M.A., Baylin, S.B. Cancer Res. (1997)
- KCTD11 expression in medulloblastoma is lower than in adult cerebellum and higher than in neural stem cells. Zawlik, I., Zakrzewska, M., Witusik, M., Golanska, E., Kulczycka-Wojdala, D., Szybka, M., Piaskowski, S., Wozniak, K., Zakrzewski, K., Papierz, W., Liberski, P.P., Rieske, P. Cancer Genet. Cytogenet. (2006)
- Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors. Koul, S., McKiernan, J.M., Narayan, G., Houldsworth, J., Bacik, J., Dobrzynski, D.L., Assaad, A.M., Mansukhani, M., Reuter, V.E., Bosl, G.J., Chaganti, R.S., Murty, V.V. Mol. Cancer (2004)
- Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Zhang, Q., Wang, S.Y., Fleuriel, C., Leprince, D., Rocheleau, J.V., Piston, D.W., Goodman, R.H. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine. Dote, H., Cerna, D., Burgan, W.E., Carter, D.J., Cerra, M.A., Hollingshead, M.G., Camphausen, K., Tofilon, P.J. Clin. Cancer Res. (2005)
- A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. Stankovic-Valentin, N., Verger, A., Deltour-Balerdi, S., Quinlan, K.G., Crossley, M., Leprince, D. FEBS J. (2006)
- Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Fujii, H., Biel, M.A., Zhou, W., Weitzman, S.A., Baylin, S.B., Gabrielson, E. Oncogene (1998)
- p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Wales, M.M., Biel, M.A., el Deiry, W., Nelkin, B.D., Issa, J.P., Cavenee, W.K., Kuerbitz, S.J., Baylin, S.B. Nat. Med. (1995)
- Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Deltour, S., Guerardel, C., Leprince, D. Proc. Natl. Acad. Sci. U.S.A. (1999)
- DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Park, H.J., Yu, E., Shim, Y.H. Cancer Lett. (2006)
- Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Aggerholm, A., Holm, M.S., Guldberg, P., Olesen, L.H., Hokland, P. Eur. J. Haematol. (2006)
- Association between CpG island methylation and microsatellite instability in colorectal cancer. Ahuja, N., Mohan, A.L., Li, Q., Stolker, J.M., Herman, J.G., Hamilton, S.R., Baylin, S.B., Issa, J.P. Cancer Res. (1997)
- An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Stankovic-Valentin, N., Deltour, S., Seeler, J., Pinte, S., Vergoten, G., Guérardel, C., Dejean, A., Leprince, D. Mol. Cell. Biol. (2007)
- The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. Pinte, S., Stankovic-Valentin, N., Deltour, S., Rood, B.R., Guérardel, C., Leprince, D. J. Biol. Chem. (2004)
- Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. Britschgi, C., Rizzi, M., Grob, T.J., Tschan, M.P., Hügli, B., Reddy, V.A., Andres, A.C., Torbett, B.E., Tobler, A., Fey, M.F. Oncogene (2006)
- Epigenetic silencing of the HIC-1 gene in human medulloblastomas. Waha, A., Waha, A., Koch, A., Meyer-Puttlitz, B., Weggen, S., Sörensen, N., Tonn, J.C., Albrecht, S., Goodyer, C.G., Berthold, F., Wiestler, O.D., Pietsch, T. J. Neuropathol. Exp. Neurol. (2003)