Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Hipk1 - homeodomain interacting protein kinase 1

Mus musculus

Synonyms: 1110062K04Rik, Homeodomain-interacting protein kinase 1, Kiaa0630, Myak, Nbak2, ...

Shang, E. et al., Isono, K. et al., Kondo, S. et al., Aikawa, Y. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hipk1

The HIPK1 gene was highly expressed in human breast cancer cell lines and oncogenically transformed mouse embryonic fibroblasts [1].

High impact information on Hipk1

Phosphorylation of p300 and AML1 is impaired in Hipk1/2 double-deficient mouse embryos [2].
HIPK1 was localized to human chromosome band 1p13, a site frequently altered in cancers [1].
The present study indicated the overlapping roles for Hipk1 and Hipk2 in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development [3].
Hipk1 Hipk2 double homozygotes are progressively lost between 9.5 and 12.5 days postcoitus and frequently fail to close the anterior neuropore and exhibit exencephaly [3].
Homeodomain-interacting protein kinase 1 (Hipk1), 2, and 3 genes encode evolutionarily conserved nuclear serine/threonine kinases, which were originally identified as interacting with homeodomain-containing proteins [3].

Anatomical context of Hipk1

RNA blot analysis revealed that Myak is expressed at low levels ubiquitously but at high levels in reproductive tissues, including testis, epididymis, ovary, uterus, and mammary gland, as well as in brain and kidney [4].
Myak is also highly expressed in the aqueduct of the adult brain and in the brain and spinal cord of day 12.5 embryos [4].
In situ hybridization analysis on selected tissues revealed that Myak is particularly abundant in the hormonally modulated epithelia of the epididymis, mammary gland, and uterus, in round spermatids in the testis, and in the corpora lutea in the ovary [4].

References

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Kondo, S., Lu, Y., Debbas, M., Lin, A.W., Sarosi, I., Itie, A., Wakeham, A., Tuan, J., Saris, C., Elliott, G., Ma, W., Benchimol, S., Lowe, S.W., Mak, T.W., Thukral, S.K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. Aikawa, Y., Nguyen, L.A., Isono, K., Takakura, N., Tagata, Y., Schmitz, M.L., Koseki, H., Kitabayashi, I. EMBO J. (2006) [Pubmed]
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Isono, K., Nemoto, K., Li, Y., Takada, Y., Suzuki, R., Katsuki, M., Nakagawara, A., Koseki, H. Mol. Cell. Biol. (2006) [Pubmed]
Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system. Shang, E., Wang, X., Huang, J., Yoshida, W., Kuroiwa, A., Wolgemuth, D.J. Mol. Reprod. Dev. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.