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Gene Review

Hnrnpa1  -  heterogeneous nuclear ribonucleoprotein A1

Mus musculus

Synonyms: D15Ertd119e, Fli-2, HDP-1, Hdp, Helix-destabilizing protein, ...
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Disease relevance of Hnrpa1


High impact information on Hnrpa1


Biological context of Hnrpa1


Anatomical context of Hnrpa1

  • Finally, we show that hnRNP A1 can be overexpressed in mouse primary hepatocytes, leading to an accumulation of the CYP2A5 mRNA [8].

Associations of Hnrpa1 with chemical compounds

  • We also show that a specific hepatotoxic inducer of the Cyp2a5 gene, pyrazole, increases the cytoplasmic levels of hnRNP A1 in vivo [8].
  • Yeast two-hybrid assays further indicated in vivo that such binding relates to the fragment (aa 161-210) of SARS_N and the Gly-rich domain (aa 203-320) of hnRNP A1 [12].

Physical interactions of Hnrpa1


Other interactions of Hnrpa1

  • Collectively, these results indicate that the hnRNP A1 is an important regulator of the Cyp2a5 gene [8].

Analytical, diagnostic and therapeutic context of Hnrpa1

  • Binding of the hnRNP A1 to CYP2A5 mRNA was demonstrated by immunoprecipitation of the xenobiotic-stimulated (37/39 kDa) CYP2A5 mRNA-protein complex with a monoclonal anti-hnRNP A1 antibody, by partial trypsin digestion of the complex, and by showing that the RNA-protein complex is not formed with protein extracts from cells lacking the hnRNP A1 [8].
  • Moreover, kinetic analyses by surface plasmon resonance (SPR) technology revealed that SARS_N protein has a specific binding affinity against human hnRNP A1 with K(D) at 0.35 +/- 0.02 microM (k(on) = 5.83 +/- 0.42 x 10(3) M(-1)s(-1) and k(off) = 2.06 +/- 0.12 x 10(-3)s(-1)) [12].


  1. Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth. Ben-David, Y., Bani, M.R., Chabot, B., De Koven, A., Bernstein, A. Mol. Cell. Biol. (1992) [Pubmed]
  2. Regulation of mouse hepatitis virus RNA synthesis by heterogeneous nuclear ribonucleoprotein A1. Shi, S.T., Huang, P., Li, H.P., Lai, M.M. Adv. Exp. Med. Biol. (2001) [Pubmed]
  3. Evaluation of the role of heterogeneous nuclear ribonucleoprotein A1 as a host factor in murine coronavirus discontinuous transcription and genome replication. Shen, X., Masters, P.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. LaBranche, H., Dupuis, S., Ben-David, Y., Bani, M.R., Wellinger, R.J., Chabot, B. Nat. Genet. (1998) [Pubmed]
  5. S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Gao, C., Guo, H., Wei, J., Mi, Z., Wai, P., Kuo, P.C. J. Biol. Chem. (2004) [Pubmed]
  6. Selective cytoplasmic translocation of HuR and site-specific binding to the interleukin-2 mRNA are not sufficient for CD28-mediated stabilization of the mRNA. Seko, Y., Azmi, H., Fariss, R., Ragheb, J.A. J. Biol. Chem. (2004) [Pubmed]
  7. Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the major histocompatibility complex. Donev, R., Horton, R., Beck, S., Doneva, T., Vatcheva, R., Bowen, W.R., Sheer, D. J. Biol. Chem. (2003) [Pubmed]
  8. Heterogeneous nuclear ribonucleoprotein A1 and regulation of the xenobiotic-inducible gene Cyp2a5. Raffalli-Mathieu, F., Glisovic, T., Ben-David, Y., Lang, M.A. Mol. Pharmacol. (2002) [Pubmed]
  9. Heterogeneous nuclear ribonucleoprotein a1 binds to the 3'-untranslated region and mediates potential 5'-3'-end cross talks of mouse hepatitis virus RNA. Huang, P., Lai, M.M. J. Virol. (2001) [Pubmed]
  10. A heterogeneous nuclear ribonucleoprotein A/B-related protein binds to single-stranded DNA near the 5' end or within the genome of feline parvovirus and can modify virus replication. Wang, D., Parrish, C.R. J. Virol. (1999) [Pubmed]
  11. Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency. Ma, H., Liu, Q., Diamond, S.L., Pierce, E.A. Methods (2004) [Pubmed]
  12. The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1. Luo, H., Chen, Q., Chen, J., Chen, K., Shen, X., Jiang, H. FEBS Lett. (2005) [Pubmed]
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