Gene Review:
Itch - itchy, E3 ubiquitin protein ligase
Mus musculus
Synonyms:
6720481N21Rik, 8030492O04Rik, A130065M08, AIP4, C230047C07Rik, ...
- Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. Hansson, L., Bäckman, A., Ny, A., Edlund, M., Ekholm, E., Ekstrand Hammarström, B., Törnell, J., Wallbrandt, P., Wennbo, H., Egelrud, T. J. Invest. Dermatol. (2002)
- In chronic idiopathic urticaria autoantibodies against Fc epsilonRII/CD23 induce histamine release via eosinophil activation. Puccetti, A., Bason, C., Simeoni, S., Millo, E., Tinazzi, E., Beri, R., Peterlana, D., Zanoni, G., Senna, G., Corrocher, R., Lunardi, C. Clin. Exp. Allergy (2005)
- Expression of nerve growth factor in itchy skins of atopic NC/NgaTnd mice. Tanaka, A., Matsuda, H. J. Vet. Med. Sci. (2005)
- Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Oliver, P.M., Cao, X., Worthen, G.S., Shi, P., Briones, N., Macleod, M., White, J., Kirby, P., Kappler, J., Marrack, P., Yang, B. Immunity (2006)
- Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Heissmeyer, V., Macián, F., Im, S.H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y.C., Dustin, M.L., Rao, A. Nat. Immunol. (2004)
- Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Fang, D., Elly, C., Gao, B., Fang, N., Altman, Y., Joazeiro, C., Hunter, T., Copeland, N., Jenkins, N., Liu, Y.C. Nat. Immunol. (2002)
- Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. Yang, C., Zhou, W., Jeon, M.S., Demydenko, D., Harada, Y., Zhou, H., Liu, Y.C. Mol. Cell (2006)
- Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation. Bai, Y., Yang, C., Hu, K., Elly, C., Liu, Y.C. Mol. Cell (2004)
- Laboratory animal allergy: an update. Bush, R.K., Stave, G.M. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. (2003)
- Itch genetically interacts with Notch1 in a mouse autoimmune disease model. Matesic, L.E., Haines, D.C., Copeland, N.G., Jenkins, N.A. Hum. Mol. Genet. (2006)
- Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling. Ikeda, A., Caldwell, R.G., Longnecker, R., Ikeda, M. J. Virol. (2003)
- Antioxidant properties of Aller-7, a novel polyherbal formulation for allergic rhinitis. D'Souza, P., Amit, A., Saxena, V.S., Bagchi, D., Bagchi, M., Stohs, S.J. Drugs under experimental and clinical research. (2004)
- Ultraviolet B induces mast cell apoptosis: a hypothetical mechanism of ultraviolet B treatment for uraemic pruritus. Szepietowski, J.C., Morita, A., Tsuji, T. Med. Hypotheses (2002)
- Algesiogenic and analgesic activities of synthetic substance P. Kotani, Y., Oka, M., Yonehara, N., Kudo, T., Inoki, R. Jpn. J. Pharmacol. (1981)
- Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Takano, H., Osakabe, N., Sanbongi, C., Yanagisawa, R., Inoue, K., Yasuda, A., Natsume, M., Baba, S., Ichiishi, E., Yoshikawa, T. Exp. Biol. Med. (Maywood) (2004)
- The Tyrosine Kinase c-Abl Protects c-Jun from Ubiquitination-mediated Degradation in T Cells. Gao, B., Lee, S.M., Fang, D. J. Biol. Chem. (2006)
- Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Gao, M., Labuda, T., Xia, Y., Gallagher, E., Fang, D., Liu, Y.C., Karin, M. Science (2004)