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Gene Review

Klk7  -  kallikrein related-peptidase 7...

Mus musculus

Synonyms: Kallikrein-7, Prss6, SCCE, Scce, Serine protease 6, ...
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Disease relevance of Klk7


High impact information on Klk7


Biological context of Klk7

  • The murine protein was deduced to have a 21 amino acid signal peptide and a four amino acid propeptide ending with a tryptic cleavage site, followed by a sequence motif identical to the N-terminal amino acid sequence of native active human SCCE [3].

Anatomical context of Klk7

  • A correlation therefore seems to exist between the presence of SCCE in high suprabasal cells and the ability of the epithelium to form an orthokeratotic cornified layer [4].

Analytical, diagnostic and therapeutic context of Klk7


  1. Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. Hansson, L., Bäckman, A., Ny, A., Edlund, M., Ekholm, E., Ekstrand Hammarström, B., Törnell, J., Wallbrandt, P., Wennbo, H., Egelrud, T. J. Invest. Dermatol. (2002) [Pubmed]
  2. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Descargues, P., Deraison, C., Bonnart, C., Kreft, M., Kishibe, M., Ishida-Yamamoto, A., Elias, P., Barrandon, Y., Zambruno, G., Sonnenberg, A., Hovnanian, A. Nat. Genet. (2005) [Pubmed]
  3. Molecular cloning and tissue expression of the murine analog to human stratum corneum chymotryptic enzyme. Bäckman, A., Strandén, P., Brattsand, M., Hansson, L., Egelrud, T. J. Invest. Dermatol. (1999) [Pubmed]
  4. Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia. Sondell, B., Thornell, L.E., Stigbrand, T., Egelrud, T. J. Histochem. Cytochem. (1994) [Pubmed]
  5. Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. Hachem, J.P., Man, M.Q., Crumrine, D., Uchida, Y., Brown, B.E., Rogiers, V., Roseeuw, D., Feingold, K.R., Elias, P.M. J. Invest. Dermatol. (2005) [Pubmed]
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